ITGAV (integrin subunit alpha V) - Rat Genome Database

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Gene: ITGAV (integrin subunit alpha V) Canis lupus familiaris
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Symbol: ITGAV
Name: integrin subunit alpha V
RGD ID: 12288715
Description: ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); extracellular matrix binding (ortholog); extracellular matrix protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); apolipoprotein A-I-mediated signaling pathway (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN integrin mediated signaling pathway; platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute myeloid leukemia (ortholog); Cerebral Hemorrhage (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); alphav-beta3 integrin-IGF-1-IGF1R complex (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: integrin alpha-V; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBI
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBI
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
apoptotic cell clearance  (ISO)
blood vessel development  (ISO)
calcium ion transmembrane transport  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell migration  (ISO)
cell-matrix adhesion  (ISO)
cell-substrate adhesion  (ISO)
endodermal cell differentiation  (ISO)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
heterotypic cell-cell adhesion  (ISO)
integrin-mediated signaling pathway  (ISO)
negative chemotaxis  (ISO)
negative regulation of entry of bacterium into host cell  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of lipid storage  (ISO)
negative regulation of lipid transport  (ISO)
negative regulation of lipoprotein metabolic process  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of small GTPase mediated signal transduction  (ISO)
regulation of phagocytosis  (ISO)
regulation of transforming growth factor beta activation  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
transforming growth factor beta production  (ISO)
vasculogenesis  (ISO)
viral entry into host cell  (ISO)

References
Additional References at PubMed
PMID:23977051  


Genomics

Comparative Map Data
ITGAV
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,815,215 - 28,890,569 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBI
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBI
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBI
ITGAV
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2186,590,056 - 186,680,901 (+)EnsemblGRCh38hg38GRCh38
GRCh382186,590,056 - 186,680,901 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372187,454,783 - 187,545,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,163,045 - 187,253,873 (+)NCBINCBI36hg18NCBI36
Build 342187,280,305 - 187,371,133NCBI
Celera2181,050,405 - 181,141,257 (+)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2179,314,524 - 179,405,486 (+)NCBIHuRef
CHM1_12187,460,842 - 187,551,625 (+)NCBICHM1_1
Itgav
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,551,625 - 83,637,261 (+)NCBIGRCm39mm39
GRCm39 Ensembl283,554,741 - 83,637,260 (+)Ensembl
GRCm38283,722,303 - 83,806,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,724,397 - 83,806,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37283,564,554 - 83,647,073 (+)NCBIGRCm37mm9NCBIm37
MGSCv36283,525,354 - 83,604,646 (+)NCBImm8
Celera285,367,604 - 85,456,006 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Itgav
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2368,838,524 - 68,926,653 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl368,838,189 - 68,926,639 (+)Ensembl
Rnor_6.0371,113,269 - 71,205,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,114,100 - 71,202,411 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,643,270 - 77,731,358 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4366,953,403 - 67,029,774 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1366,848,789 - 66,926,146 (+)NCBI
Celera368,209,136 - 68,297,332 (+)NCBICelera
Cytogenetic Map3q24NCBI
Itgav
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,592,339 - 11,659,297 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,588,536 - 11,669,809 (-)NCBIChiLan1.0ChiLan1.0
ITGAV
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B191,680,655 - 191,773,028 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B191,680,655 - 191,773,028 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B73,880,962 - 73,972,486 (+)NCBIMhudiblu_PPA_v0panPan3
Itgav
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303145,999,260 - 146,087,955 (+)NCBI
SpeTri2.0NW_00493650610,750,116 - 10,839,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAV
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,604,676 - 91,711,840 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,604,666 - 91,711,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,654,958 - 101,717,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAV
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,125,710 - 72,216,757 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,125,962 - 72,216,809 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040127,289,910 - 127,381,992 (-)NCBIVero_WHO_p1.0
Itgav
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248993,235,434 - 3,292,584 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 5 12 10 6
Low 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023277   ⟹   ENSCAFP00000021616
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3628,815,166 - 28,887,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063940   ⟹   ENSCAFP00000044195
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3628,815,197 - 28,887,430 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065261   ⟹   ENSCAFP00000050990
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3628,804,013 - 28,887,430 (+)Ensembl
RefSeq Acc Id: XM_038446753   ⟹   XP_038302681
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03629,028,662 - 29,116,151 (+)NCBI
RefSeq Acc Id: XM_038463276   ⟹   XP_038319204
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
RefSeq Acc Id: XM_038463277   ⟹   XP_038319205
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3628,702,231 - 28,789,503 (+)NCBI
RefSeq Acc Id: XM_038521369   ⟹   XP_038377297
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13629,087,085 - 29,173,016 (+)NCBI
RefSeq Acc Id: XM_038584523   ⟹   XP_038440451
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03629,188,373 - 29,276,043 (+)NCBI
RefSeq Acc Id: XM_038649473   ⟹   XP_038505401
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
RefSeq Acc Id: XM_038649474   ⟹   XP_038505402
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03629,020,979 - 29,108,231 (+)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000044195   ⟸   ENSCAFT00000063940
RefSeq Acc Id: ENSCAFP00000021616   ⟸   ENSCAFT00000023277
RefSeq Acc Id: ENSCAFP00000050990   ⟸   ENSCAFT00000065261
RefSeq Acc Id: XP_038377297   ⟸   XM_038521369
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038505401   ⟸   XM_038649473
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038505402   ⟸   XM_038649474
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038302681   ⟸   XM_038446753
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038319204   ⟸   XM_038463276
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038319205   ⟸   XM_038463277
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038440451   ⟸   XM_038584523
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014597 Ensembl
NCBI Gene ITGAV ENTREZGENE
VGNC ID VGNC:42134 ENTREZGENE