RGD Reference Report - The integrins. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The integrins.

Authors: Takada, Yoshikazu  Ye, Xiaojing  Simon, Scott 
Citation: Takada Y, etal., Genome Biol. 2007;8(5):215.
RGD ID: 5135538
Pubmed: PMID:17543136   (View Abstract at PubMed)
PMCID: PMC1929136   (View Article at PubMed Central)
DOI: DOI:10.1186/gb-2007-8-5-215   (Journal Full-text)

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and zebrafish, as well as lower eukaryotes, including sponges, the nematode Caenorhabditis elegans (two alpha and one beta subunits, generating two integrins) and the fruitfly Drosophila melanogaster (five alpha and one beta, generating five integrins). The alpha and beta subunits have distinct domain structures, with extracellular domains from each subunit contributing to the ligand-binding site of the heterodimer. The sequence arginine-glycine-aspartic acid (RGD) was identified as a general integrin-binding motif, but individual integrins are also specific for particular protein ligands. Immunologically important integrin ligands are the intercellular adhesion molecules (ICAMs), immunoglobulin superfamily members present on inflamed endothelium and antigen-presenting cells. On ligand binding, integrins transduce signals into the cell interior; they can also receive intracellular signals that regulate their ligand-binding affinity. Here we provide a brief overview that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied than integrins in other organisms.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGA1Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA10Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA11Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA2Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA2BHumanintegrin mediated signaling pathway   TAS  RGD 
ITGA3Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA4Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA5Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA6Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA7Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA8Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA9Humanintegrin mediated signaling pathway   TAS  RGD 
ITGADHumanintegrin mediated signaling pathway   TAS  RGD 
ITGAEHumanintegrin mediated signaling pathway   TAS  RGD 
ITGALHumanintegrin mediated signaling pathway   TAS  RGD 
ITGAMHumanintegrin mediated signaling pathway   TAS  RGD 
ITGAVHumanintegrin mediated signaling pathway   TAS  RGD 
ITGAXHumanintegrin mediated signaling pathway   TAS  RGD 
ITGB1Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB2Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB3Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB4Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB5Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB6Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB7Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB8Humanintegrin mediated signaling pathway   TAS  RGD 
Itga1Ratintegrin mediated signaling pathway   ISOITGA1 (Homo sapiens) RGD 
Itga1Mouseintegrin mediated signaling pathway   ISOITGA1 (Homo sapiens) RGD 
Itga10Ratintegrin mediated signaling pathway   ISOITGA10 (Homo sapiens) RGD 
Itga10Mouseintegrin mediated signaling pathway   ISOITGA10 (Homo sapiens) RGD 
Itga11Ratintegrin mediated signaling pathway   ISOITGA11 (Homo sapiens) RGD 
Itga11Mouseintegrin mediated signaling pathway   ISOITGA11 (Homo sapiens) RGD 
Itga2Ratintegrin mediated signaling pathway   ISOITGA2 (Homo sapiens) RGD 
Itga2Mouseintegrin mediated signaling pathway   ISOITGA2 (Homo sapiens) RGD 
Itga2bMouseintegrin mediated signaling pathway   ISOITGA2B (Homo sapiens) RGD 
Itga2bRatintegrin mediated signaling pathway   ISOITGA2B (Homo sapiens)based on Entrez HomoloGene and BLASTRGD 
Itga3Ratintegrin mediated signaling pathway   ISO RGD 
Itga3Mouseintegrin mediated signaling pathway   ISOITGA3 (Homo sapiens) RGD 
Itga4Mouseintegrin mediated signaling pathway   ISOITGA4 (Homo sapiens) RGD 
Itga4Ratintegrin mediated signaling pathway   ISOITGA4 (Homo sapiens) RGD 
Itga5Ratintegrin mediated signaling pathway   ISOITGA5 (Homo sapiens) RGD 
Itga5Mouseintegrin mediated signaling pathway   ISOITGA5 (Homo sapiens) RGD 
Itga6Ratintegrin mediated signaling pathway   ISOITGA6 (Homo sapiens) RGD 
Itga6Mouseintegrin mediated signaling pathway   ISOITGA6 (Homo sapiens) RGD 
Itga7Ratintegrin mediated signaling pathway   ISOITGA7 (Homo sapiens) RGD 
Itga7Mouseintegrin mediated signaling pathway   ISOITGA7 (Homo sapiens) RGD 
Itga8Ratintegrin mediated signaling pathway   ISOITGA8 (Homo sapiens) RGD 
Itga8Mouseintegrin mediated signaling pathway   ISOITGA8 (Homo sapiens) RGD 
Itga9Ratintegrin mediated signaling pathway   ISOITGA9 (Homo sapiens) RGD 
Itga9Mouseintegrin mediated signaling pathway   ISOITGA9 (Homo sapiens) RGD 
ItgadRatintegrin mediated signaling pathway   ISOITGAD (Homo sapiens) RGD 
ItgadMouseintegrin mediated signaling pathway   ISOITGAD (Homo sapiens) RGD 
ItgaeRatintegrin mediated signaling pathway   ISOITGAE (Homo sapiens) RGD 
ItgaeMouseintegrin mediated signaling pathway   ISOITGAE (Homo sapiens) RGD 
ItgalRatintegrin mediated signaling pathway   ISOITGAL (Homo sapiens) RGD 
ItgalMouseintegrin mediated signaling pathway   ISOITGAL (Homo sapiens) RGD 
ItgamRatintegrin mediated signaling pathway   ISOITGAM (Homo sapiens) RGD 
ItgamMouseintegrin mediated signaling pathway   ISOITGAM (Homo sapiens) RGD 
ItgavRatintegrin mediated signaling pathway   ISOITGAV (Homo sapiens) RGD 
ItgavMouseintegrin mediated signaling pathway   ISOITGAV (Homo sapiens) RGD 
ItgaxMouseintegrin mediated signaling pathway   ISOITGAX (Homo sapiens) RGD 
ItgaxRatintegrin mediated signaling pathway   ISOITGAX (Homo sapiens) RGD 
Itgb1Ratintegrin mediated signaling pathway   ISOITGB1 (Homo sapiens) RGD 
Itgb1Mouseintegrin mediated signaling pathway   ISOITGB1 (Homo sapiens) RGD 
Itgb2Ratintegrin mediated signaling pathway   ISOITGB2 (Homo sapiens) RGD 
Itgb2Mouseintegrin mediated signaling pathway   ISOITGB2 (Homo sapiens) RGD 
Itgb3Ratintegrin mediated signaling pathway   ISOITGB3 (Homo sapiens) RGD 
Itgb3Mouseintegrin mediated signaling pathway   ISOITGB3 (Homo sapiens) RGD 
Itgb4Ratintegrin mediated signaling pathway   ISOITGB4 (Homo sapiens) RGD 
Itgb4Mouseintegrin mediated signaling pathway   ISOITGB4 (Homo sapiens) RGD 
Itgb5Ratintegrin mediated signaling pathway   ISOITGB5 (Homo sapiens) RGD 
Itgb5Mouseintegrin mediated signaling pathway   ISOITGB5 (Homo sapiens) RGD 
Itgb6Ratintegrin mediated signaling pathway   ISOITGB6 (Homo sapiens) RGD 
Itgb6Mouseintegrin mediated signaling pathway   ISOITGB6 (Homo sapiens) RGD 
Itgb7Ratintegrin mediated signaling pathway   ISOITGB7 (Homo sapiens) RGD 
Itgb7Mouseintegrin mediated signaling pathway   ISOITGB7 (Homo sapiens) RGD 
Itgb8Ratintegrin mediated signaling pathway   ISOITGB8 (Homo sapiens) RGD 
Itgb8Mouseintegrin mediated signaling pathway   ISOITGB8 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Itga1  (integrin subunit alpha 1)
Itga10  (integrin subunit alpha 10)
Itga11  (integrin subunit alpha 11)
Itga2  (integrin subunit alpha 2)
Itga2b  (integrin subunit alpha 2b)
Itga3  (integrin subunit alpha 3)
Itga4  (integrin subunit alpha 4)
Itga5  (integrin subunit alpha 5)
Itga6  (integrin subunit alpha 6)
Itga7  (integrin subunit alpha 7)
Itga8  (integrin subunit alpha 8)
Itga9  (integrin subunit alpha 9)
Itgad  (integrin subunit alpha D)
Itgae  (integrin subunit alpha E)
Itgal  (integrin subunit alpha L)
Itgam  (integrin subunit alpha M)
Itgav  (integrin subunit alpha V)
Itgax  (integrin subunit alpha X)
Itgb1  (integrin subunit beta 1)
Itgb2  (integrin subunit beta 2)
Itgb3  (integrin subunit beta 3)
Itgb4  (integrin subunit beta 4)
Itgb5  (integrin subunit beta 5)
Itgb6  (integrin subunit beta 6)
Itgb7  (integrin subunit beta 7)
Itgb8  (integrin subunit beta 8)

Genes (Mus musculus)
Itga1  (integrin alpha 1)
Itga10  (integrin, alpha 10)
Itga11  (integrin alpha 11)
Itga2  (integrin alpha 2)
Itga2b  (integrin alpha 2b)
Itga3  (integrin alpha 3)
Itga4  (integrin alpha 4)
Itga5  (integrin alpha 5 (fibronectin receptor alpha))
Itga6  (integrin alpha 6)
Itga7  (integrin alpha 7)
Itga8  (integrin alpha 8)
Itga9  (integrin alpha 9)
Itgad  (integrin, alpha D)
Itgae  (integrin alpha E, epithelial-associated)
Itgal  (integrin alpha L)
Itgam  (integrin alpha M)
Itgav  (integrin alpha V)
Itgax  (integrin alpha X)
Itgb1  (integrin beta 1 (fibronectin receptor beta))
Itgb2  (integrin beta 2)
Itgb3  (integrin beta 3)
Itgb4  (integrin beta 4)
Itgb5  (integrin beta 5)
Itgb6  (integrin beta 6)
Itgb7  (integrin beta 7)
Itgb8  (integrin beta 8)

Genes (Homo sapiens)
ITGA1  (integrin subunit alpha 1)
ITGA10  (integrin subunit alpha 10)
ITGA11  (integrin subunit alpha 11)
ITGA2  (integrin subunit alpha 2)
ITGA2B  (integrin subunit alpha 2b)
ITGA3  (integrin subunit alpha 3)
ITGA4  (integrin subunit alpha 4)
ITGA5  (integrin subunit alpha 5)
ITGA6  (integrin subunit alpha 6)
ITGA7  (integrin subunit alpha 7)
ITGA8  (integrin subunit alpha 8)
ITGA9  (integrin subunit alpha 9)
ITGAD  (integrin subunit alpha D)
ITGAE  (integrin subunit alpha E)
ITGAL  (integrin subunit alpha L)
ITGAM  (integrin subunit alpha M)
ITGAV  (integrin subunit alpha V)
ITGAX  (integrin subunit alpha X)
ITGB1  (integrin subunit beta 1)
ITGB2  (integrin subunit beta 2)
ITGB3  (integrin subunit beta 3)
ITGB4  (integrin subunit beta 4)
ITGB5  (integrin subunit beta 5)
ITGB6  (integrin subunit beta 6)
ITGB7  (integrin subunit beta 7)
ITGB8  (integrin subunit beta 8)


Additional Information