Itgam (integrin subunit alpha M) - Rat Genome Database

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Gene: Itgam (integrin subunit alpha M) Rattus norvegicus
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Symbol: Itgam
Name: integrin subunit alpha M
RGD ID: 2926
Description: Used to study mesangial proliferative glomerulonephritis; neutropenia; stroke; and transient cerebral ischemia. Biomarker of brain ischemia; diabetic retinopathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M); PARTICIPATES IN integrin mediated signaling pathway; Entamoebiasis pathway; Leishmaniasis pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cd11b; integrin alpha M; Integrin alpha-M; integrin, alpha M
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,089,496 - 192,139,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,089,542 - 192,139,943 (+)EnsemblGRCr8
mRatBN7.21182,659,047 - 182,709,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,659,000 - 182,709,503 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,009,691 - 191,059,554 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,195,778 - 198,245,649 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,866,175 - 190,916,092 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1191,405,241 - 191,449,619 (+)NCBI
Lyon_Normotensive1196,407,414 - 196,451,794 (+)NCBI
Lyon_Hypertensive1193,074,965 - 193,119,348 (+)NCBI
F344_StmMcwi1191,365,191 - 191,409,582 (+)NCBI
Rnor_6.01199,495,312 - 199,545,738 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,495,298 - 199,623,960 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01206,522,794 - 206,573,619 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,334,413 - 187,385,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,308,890 - 180,355,319 (+)NCBICelera
RGSC_v3.11187,484,293 - 187,535,464 (+)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (IEP,IMP)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute promyelocytic leukemia  (ISO)
allergic contact dermatitis  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
Brain Death  (IEP)
brain ischemia  (IEP)
Breast Cancer, Familial  (ISO)
Burns  (IMP)
cerebral infarction  (ISO)
cholangiocarcinoma  (ISO)
clear cell renal cell carcinoma  (ISO)
colon adenocarcinoma  (ISO)
Coronary Disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
diabetic retinopathy  (IEP)
disease by infectious agent  (ISO)
esophageal cancer  (ISO)
Experimental Diabetes Mellitus  (IEP)
familial hyperlipidemia  (ISO)
glomerulonephritis  (ISO)
goiter  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
hyperthyroidism  (ISO)
ileitis  (ISO)
Insulin Resistance  (ISO)
intermediate coronary syndrome  (ISO)
Invasive Candidiasis  (ISO)
limb ischemia  (ISO)
Liver Reperfusion Injury  (IEP,IMP)
Lung Injury  (IMP)
lung squamous cell carcinoma  (ISO)
lupus nephritis  (ISO)
Lupus Vasculitis, Central Nervous System  (ISO)
Memory Disorders  (ISO)
mesangial proliferative glomerulonephritis  (IMP)
myocardial infarction  (ISO)
myopia  (ISO)
nephritis  (ISO)
Nerve Degeneration  (ISO)
Neuralgia  (IEP)
neutropenia  (IMP)
obesity  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
peritonitis  (ISO)
persistent fetal circulation syndrome  (ISO)
pre-eclampsia  (ISO)
respiratory failure  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP)
Skeletal Muscle Reperfusion Injury  (IEP)
Spinal Cord Compression  (IEP)
stomach cancer  (ISO)
stroke  (IMP)
systemic lupus erythematosus  (ISO)
thrombosis  (ISO)
thymoma  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
transient cerebral ischemia  (IEP,IMP,ISO)
type 2 diabetes mellitus  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
agathisflavone  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
alternariol  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
Antimony trioxide  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cyclizine  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
DAPT  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dichlorvos  (EXP)
diclofenac  (ISO)
dimemorfan  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epalrestat  (ISO)
Erythropoietin  (ISO)
estrone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
everolimus  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
gallic acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyburide  (EXP)
GW 4064  (ISO)
halothane  (ISO)
heparin  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
imidacloprid  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
kainic acid  (ISO)
KT 5720  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead nitrate  (ISO)
leukotriene B4  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
low-density lipoprotein  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mannitol  (ISO)
mechlorethamine  (EXP)
memantine  (EXP)
methamphetamine  (EXP,ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
midazolam  (ISO)
minocycline  (ISO)
ML-7  (ISO)
morphine  (ISO)
Morphine-3-glucuronide  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naled  (ISO)
naloxone  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
notoginsenoside R1  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
Oleacein  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pinostrobin  (ISO)
pitavastatin  (ISO)
PJ34  (EXP)
plaunotol  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(I:C)  (EXP)
poly(styrene)  (ISO)
progesterone  (ISO)
pyrithiamine  (EXP)
pyrithione  (ISO)
quartz  (EXP)
quercetin  (ISO)
reparixin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rolipram  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
ryanodine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serotonin  (ISO)
sevoflurane  (EXP)
SHP099  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sodium stibogluconate  (ISO)
Soman  (EXP)
staurosporine  (ISO)
sterigmatocystin  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfoxaflor  (EXP)
T-2 toxin  (ISO)
tacrine  (EXP)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tepoxalin  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
TMC-120A  (ISO)
tributylstannane  (EXP,ISO)
trichostatin A  (ISO)
trimethyltin  (EXP,ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
xestospongin C  (ISO)
Y-27632  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues. Atcha H, etal., Front Immunol. 2021 Sep 22;12:689397. doi: 10.3389/fimmu.2021.689397. eCollection 2021.
2. Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications. Awamleh Z and Han VKM, Pregnancy Hypertens. 2020 Jan;19:159-168. doi: 10.1016/j.preghy.2020.01.002. Epub 2020 Jan 14.
3. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Barouch FC, etal., Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1153-8.
4. Perioperative platelet and monocyte activation in patients with critical limb ischemia. Burdess A, etal., J Vasc Surg. 2010 Sep;52(3):697-703. doi: 10.1016/j.jvs.2010.04.024.
5. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns. Choi M, etal., Plast Reconstr Surg. 1995 Oct;96(5):1177-85; discussion 1186-7.
6. Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain. Chopp M, etal., J Cereb Blood Flow Metab. 1996 Jul;16(4):578-84. doi: 10.1097/00004647-199607000-00007.
7. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Chopp M, etal., Stroke. 1994 Apr;25(4):869-75; discussion 875-6. doi: 10.1161/01.str.25.4.869.
8. Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats. Clark RS, etal., J Neurotrauma. 1996 Jun;13(6):333-41. doi: 10.1089/neu.1996.13.333.
9. Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein. Czerwińska ME, etal., Food Chem. 2014 Jun 15;153:1-8. doi: 10.1016/j.foodchem.2013.12.019. Epub 2013 Dec 11.
10. Differential Plasma Protein Regulation and Statin Effects in Human Immunodeficiency Virus (HIV)-Infected and Non-HIV-Infected Patients Utilizing a Proteomics Approach. deFilippi C, etal., J Infect Dis. 2020 Aug 17;222(6):929-939. doi: 10.1093/infdis/jiaa196.
11. Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity. Devaraj S and Jialal I, Arch Pathol Lab Med. 2008 Sep;132(9):1432-5. doi: 10.5858/2008-132-1432-VOTCMB.
12. Global ischemia-induced modifications in the expression of AMPA receptors and inflammation in rat brain. Dos-Anjos S, etal., Brain Res. 2009 Sep 1;1287:20-7. doi: 10.1016/j.brainres.2009.06.065. Epub 2009 Jun 27.
13. Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactions. Eisenhardt SU, etal., Atherosclerosis. 2012 Oct;224(2):384-93. doi: 10.1016/j.atherosclerosis.2012.07.039. Epub 2012 Aug 10.
14. Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Gao D, etal., Free Radic Biol Med. 2012 Aug 15;53(4):796-806. doi: 10.1016/j.freeradbiomed.2012.05.026. Epub 2012 May 26.
15. The effect of midazolam on neutrophil mitogen-activated protein kinase. Ghori K, etal., Eur J Anaesthesiol. 2010 Jun;27(6):562-5. doi: 10.1097/EJA.0b013e3283328442.
16. The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers. Gourdin M, etal., J Cardiovasc Pharmacol. 2012 Dec;60(6):553-60. doi: 10.1097/FJC.0b013e31827303fa.
17. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
18. Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes. Horvath P, etal., J Investig Med. 2013 Aug;61(6):972-7. doi: 10.2310/JIM.0b013e3182961517.
19. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
20. Determinants of platelet conjugate formation with polymorphonuclear leukocytes or monocytes in whole blood. Izzi B, etal., Thromb Haemost. 2007 Dec;98(6):1276-84.
21. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Jaeschke H, etal., Hepatology. 1993 May;17(5):915-23.
22. [Effect of curcumin on expressions of CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment]. Jiang J, etal., Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Feb;31(2):221-224. doi: 10.3760/cma.j.issn.2095-4352.2019.02.019.
23. Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia. Ju F, etal., Front Cell Neurosci. 2018 Aug 3;12:236. doi: 10.3389/fncel.2018.00236. eCollection 2018.
24. Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver. Kobayashi A, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G577-85. doi: 10.1152/ajpgi.2001.281.2.G577.
25. Translocator protein localises to CD11b+ macrophages in atherosclerosis. Kopecky C, etal., Atherosclerosis. 2019 May;284:153-159. doi: 10.1016/j.atherosclerosis.2019.03.011. Epub 2019 Mar 18.
26. Persistent behavioral impairments and neuroinflammation following global ischemia in the rat. Langdon KD, etal., Eur J Neurosci. 2008 Dec;28(11):2310-8. doi: 10.1111/j.1460-9568.2008.06513.x. Epub 2008 Nov 3.
27. Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury. Lee C, etal., J Trauma. 2005 Jul;59(1):56-63; discussion 63. doi: 10.1097/01.ta.0000171456.54921.fe.
28. The pattern of inflammation in rat sepsis due to enterotoxin-producing Staphylococcus aureus: a comparison with ischemia-reperfusion injury. Lin RY, etal., J Med. 1996;27(5-6):303-17.
29. Organ-specific innate immune responses in a mouse model of invasive candidiasis. Lionakis MS, etal., J Innate Immun. 2011;3(2):180-99. doi: 10.1159/000321157. Epub 2010 Nov 9.
30. Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting. Liu LL, etal., Int Immunopharmacol. 2011 Apr;11(4):480-4. doi: 10.1016/j.intimp.2010.12.019. Epub 2011 Jan 14.
31. Signature of subclinical femoral artery atherosclerosis in peripheral blood mononuclear cells. Llorente-Cortés V, etal., Eur J Clin Invest. 2014 Jun;44(6):539-48. doi: 10.1111/eci.12267.
32. Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study. Lokki AI, etal., BJOG. 2021 Jul;128(8):1282-1291. doi: 10.1111/1471-0528.16660. Epub 2021 Mar 14.
33. Age, gender and disease-related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behçet's disease. Macey M, etal., Rheumatology (Oxford). 2011 Oct;50(10):1849-59. doi: 10.1093/rheumatology/ker177. Epub 2011 Jun 29.
34. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Maiguel D, etal., Sci Signal. 2011 Sep 6;4(189):ra57. doi: 10.1126/scisignal.2001811.
35. A Genetic Model of Constitutively Active Integrin CD11b/CD18. Martinez L, etal., J Immunol. 2020 Nov 1;205(9):2545-2553. doi: 10.4049/jimmunol.1901402. Epub 2020 Sep 16.
36. Down regulation of CD11b and CD18 expression in children with hypercholesterolemia: a preliminary report. Martino F, etal., Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):105-9. doi: 10.1016/j.numecd.2008.05.001. Epub 2008 Aug 3.
37. Neutrophil surface expression of CD11b and CD62L in diabetic microangiopathy. Mastej K and Adamiec R, Acta Diabetol. 2008 Sep;45(3):183-90. doi: 10.1007/s00592-008-0040-0. Epub 2008 May 22.
38. Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Mauler M, etal., Circulation. 2019 Feb 12;139(7):918-931. doi: 10.1161/CIRCULATIONAHA.118.033942.
39. Primed polymorphonuclear leukocytes constitute a possible link between inflammation and oxidative stress in hyperlipidemic patients. Mazor R, etal., Atherosclerosis. 2008 Apr;197(2):937-43. doi: 10.1016/j.atherosclerosis.2007.08.014. Epub 2007 Sep 17.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. Roles of beta 2 integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury. Mulligan MS, etal., J Immunol. 1992 Mar 15;148(6):1847-57.
42. Circulating platelet and neutrophil activation correlates with the clinical course of unstable angina. Murasaki S, etal., Heart Vessels. 2007 Nov;22(6):376-82. doi: 10.1007/s00380-007-0999-4. Epub 2007 Nov 26.
43. High-density lipoprotein reduces the human monocyte inflammatory response. Murphy AJ, etal., Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2071-7. doi: 10.1161/ATVBAHA.108.168690. Epub 2008 Jul 10.
44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation. Niyonzima N, etal., J Immunol. 2015 Jul 1;195(1):257-64. doi: 10.4049/jimmunol.1403044. Epub 2015 May 29.
46. Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants. O'Hare FM, etal., Pediatr Res. 2015 Jul;78(1):82-90. doi: 10.1038/pr.2015.66. Epub 2015 Mar 31.
47. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
48. Monocyte-platelet aggregates and CD11b expression as markers for thrombogenicity in atrial fibrillation. Pfluecke C, etal., Clin Res Cardiol. 2016 Apr;105(4):314-22. doi: 10.1007/s00392-015-0922-4. Epub 2015 Sep 28.
49. Atrial fibrillation is associated with high levels of monocyte-platelet-aggregates and increased CD11b expression in patients with aortic stenosis. Pfluecke C, etal., Thromb Haemost. 2016 May 2;115(5):993-1000. doi: 10.1160/TH15-06-0477. Epub 2016 Jan 14.
50. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
51. GOA pipeline RGD automated data pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetes. Ritter L, etal., Microcirculation. 2011 Oct;18(7):552-61. doi: 10.1111/j.1549-8719.2011.00115.x.
55. Hemodynamic resuscitation with arginine vasopressin reduces lung injury after brain death in the transplant donor. Rostron AJ, etal., Transplantation. 2008 Feb 27;85(4):597-606. doi: 10.1097/TP.0b013e31816398dd.
56. Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats. Ryang YM, etal., BMC Neurosci. 2011 Nov 14;12:113. doi: 10.1186/1471-2202-12-113.
57. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Sanchez E, etal., Ann Rheum Dis. 2011 Jun 30.
58. Modulatory effect of 17β-estradiol on myeloid cell infiltration into the male rat brain after ischemic stroke. Scheld M, etal., J Steroid Biochem Mol Biol. 2020 Sep;202:105667. doi: 10.1016/j.jsbmb.2020.105667. Epub 2020 May 11.
59. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. Scholtes VP, etal., Clin Sci (Lond). 2011 Sep;121(5):205-14. doi: 10.1042/CS20100601.
60. Role of beta 2 integrins and ICAM-1 in lung injury following ischemia-reperfusion of rat hind limbs. Seekamp A, etal., Am J Pathol. 1993 Aug;143(2):464-72.
61. Is Iba-1 protein expression a sensitive marker for microglia activation in experimental diabetic retinopathy? Shi FJ, etal., Int J Ophthalmol. 2021 Feb 18;14(2):200-208. doi: 10.18240/ijo.2021.02.04. eCollection 2021.
62. Ischemic limb preconditioning downregulates systemic inflammatory activation. Szabó A, etal., J Orthop Res. 2009 Jul;27(7):897-902. doi: 10.1002/jor.20829.
63. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
64. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Tamatani T, etal., Eur J Immunol. 1991 Mar;21(3):627-33.
65. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
66. Reduction of atrial fibrillation burden by pulmonary vein isolation leads to a decrease of CD11b expression on inflammatory cells. Tarnowski D, etal., Europace. 2018 Mar 1;20(3):459-465. doi: 10.1093/europace/euw383.
67. Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. Tian DS, etal., J Neurochem. 2009 Jun;109(6):1658-67. doi: 10.1111/j.1471-4159.2009.06077.x. Epub 2009 Mar 30.
68. δ-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat. Tian X, etal., PLoS One. 2013 Jul 2;8(7):e69252. doi: 10.1371/journal.pone.0069252. Print 2013.
69. Neutrophil-derived reactive oxygen species can modulate neutrophil adhesion to endothelial cells in preeclampsia. Tsukimori K, etal., Am J Hypertens. 2008 May;21(5):587-91. doi: 10.1038/ajh.2007.87. Epub 2008 Mar 6.
70. RNA-seq based transcriptome analysis of the protective effect of compound longmaining decoction on acute myocardial infarction. Wang C, etal., J Pharm Biomed Anal. 2018 Sep 5;158:339-345. doi: 10.1016/j.jpba.2018.06.016. Epub 2018 Jun 18.
71. Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia. Wang J, etal., Int J Mol Med. 2013 Jan;31(1):172-8. doi: 10.3892/ijmm.2012.1179. Epub 2012 Nov 13.
72. Frequent mutation of hypoxia-related genes in persistent pulmonary hypertension of the newborn. Wang M, etal., Respir Res. 2020 Feb 13;21(1):53. doi: 10.1186/s12931-020-1314-5.
73. Inhibition of microglial activation contributes to propofol-induced protection against post-cardiac arrest brain injury in rats. Wang W, etal., J Neurochem. 2015 Sep;134(5):892-903. doi: 10.1111/jnc.13179. Epub 2015 Jun 11.
74. Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell. Wang X, etal., ACS Chem Neurosci. 2019 Aug 21;10(8):3622-3634. doi: 10.1021/acschemneuro.9b00225. Epub 2019 Jul 17.
75. Protective Effects of Modeled Superoxide Dismutase Coordination Compound (MSODa) Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle. Wang XT, etal., Cell Physiol Biochem. 2015;37(2):465-76. doi: 10.1159/000430369. Epub 2015 Aug 28.
76. Proteomic analysis of foot ulcer tissue reveals novel potential therapeutic targets of wound healing in diabetic foot ulcers. Wang Y, etal., Comput Biol Med. 2023 Jun;159:106858. doi: 10.1016/j.compbiomed.2023.106858. Epub 2023 Apr 13.
77. Harmful neutrophil subsets in patients with ischemic stroke: Association with disease severity. Weisenburger-Lile D, etal., Neurol Neuroimmunol Neuroinflamm. 2019 May 15;6(4):e571. doi: 10.1212/NXI.0000000000000571. eCollection 2019 Jul.
78. Distinctive roles of neutrophils and monocytes in anti-thy-1 nephritis. Westerhuis R, etal., Am J Pathol. 2000 Jan;156(1):303-10. doi: 10.1016/S0002-9440(10)64731-1.
79. Sustained monocyte activation in clinical remission of systemic vasculitis. Wikman A, etal., Inflammation. 2008 Dec;31(6):384-90. doi: 10.1007/s10753-008-9089-8.
80. Erythropoietin protects the inner blood-retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy. Xie H, etal., Diabetologia. 2021 Jan;64(1):211-225. doi: 10.1007/s00125-020-05299-x. Epub 2020 Oct 26.
81. Intracoronary shear-related up-regulation of platelet P-selectin and platelet-monocyte aggregation despite the use of aspirin and clopidogrel. Yong AS, etal., Blood. 2011 Jan 6;117(1):11-20. doi: 10.1182/blood-2010-04-278812. Epub 2010 Sep 27.
82. Effects of a selective CD11b/CD18 antagonist and recombinant human tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke. Zhang L, etal., Stroke. 2003 Jul;34(7):1790-5. doi: 10.1161/01.STR.0000077016.55891.2E. Epub 2003 Jun 12.
83. Postischemic treatment (2-4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat. Zhang ZG, etal., Brain Res. 1995 Nov 6;698(1-2):79-85. doi: 10.1016/0006-8993(95)00830-j.
84. Deficiency of ITGAM Attenuates Experimental Abdominal Aortic Aneurysm in Mice. Zhou M, etal., J Am Heart Assoc. 2021 Apr 6;10(7):e019900. doi: 10.1161/JAHA.120.019900. Epub 2021 Mar 20.
Additional References at PubMed
PMID:8043862   PMID:8552190   PMID:8557754   PMID:8562500   PMID:8769481   PMID:8788039   PMID:8986723   PMID:9324354   PMID:9862668   PMID:10528208   PMID:10848813   PMID:12163569  
PMID:12496435   PMID:12529407   PMID:14609575   PMID:15072240   PMID:15138196   PMID:15210787   PMID:15457581   PMID:15795238   PMID:15845452   PMID:16093349   PMID:16680014   PMID:16937496  
PMID:16973387   PMID:18685038   PMID:18981141   PMID:19015308   PMID:19234460   PMID:19342649   PMID:19575970   PMID:19723499   PMID:20199584   PMID:20228271   PMID:20578039   PMID:20660734  
PMID:21193407   PMID:22099750   PMID:22438044   PMID:22632727   PMID:23154389   PMID:23376485   PMID:23533145   PMID:23550035   PMID:23981064   PMID:24029230   PMID:24913911   PMID:25645918  
PMID:25667449   PMID:28807980  


Genomics

Comparative Map Data
Itgam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,089,496 - 192,139,947 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,089,542 - 192,139,943 (+)EnsemblGRCr8
mRatBN7.21182,659,047 - 182,709,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,659,000 - 182,709,503 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,009,691 - 191,059,554 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,195,778 - 198,245,649 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,866,175 - 190,916,092 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1191,405,241 - 191,449,619 (+)NCBI
Lyon_Normotensive1196,407,414 - 196,451,794 (+)NCBI
Lyon_Hypertensive1193,074,965 - 193,119,348 (+)NCBI
F344_StmMcwi1191,365,191 - 191,409,582 (+)NCBI
Rnor_6.01199,495,312 - 199,545,738 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,495,298 - 199,623,960 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01206,522,794 - 206,573,619 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,334,413 - 187,385,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,308,890 - 180,355,319 (+)NCBICelera
RGSC_v3.11187,484,293 - 187,535,464 (+)NCBI
Cytogenetic Map1q37NCBI
ITGAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,259,975 - 31,332,877 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,259,954 - 31,332,892 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371631,271,296 - 31,344,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,178,789 - 31,251,714 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341631,178,811 - 31,251,691NCBI
Celera1628,953,869 - 29,026,766 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,832,071 - 28,904,704 (+)NCBIHuRef
CHM1_11632,589,199 - 32,661,884 (+)NCBICHM1_1
T2T-CHM13v2.01631,647,380 - 31,720,298 (+)NCBIT2T-CHM13v2.0
Itgam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,661,812 - 127,717,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,661,808 - 127,717,753 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,062,640 - 128,118,491 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBIMGSCv36mm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.93NCBI
Itgam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,116,834 - 8,260,759 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554938,116,886 - 8,160,806 (+)NCBIChiLan1.0ChiLan1.0
ITGAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,467,770 - 34,540,427 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,269,199 - 39,341,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,634,476 - 23,707,147 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,630,983 - 31,702,406 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,630,146 - 31,702,406 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ITGAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,944,062 - 16,996,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,808,971 - 16,996,286 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha618,516,000 - 18,571,559 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0617,068,771 - 17,127,224 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,069,907 - 17,127,159 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,871,848 - 16,927,654 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,791,010 - 16,846,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,102,490 - 17,158,038 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap110123,494,334 - 123,543,879 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024409344125,528,028 - 125,576,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,461,307 - 8,508,524 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,460,526 - 8,508,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1528,281,673 - 28,361,539 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660681,400,356 - 1,493,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1527,957,162 - 28,042,697 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,957,324 - 28,042,691 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Itgam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478214,316,505 - 14,367,841 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462478214,318,499 - 14,367,922 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2314,106,230 - 14,166,749 (+)Ensembl

Variants

.
Variants in Itgam
229 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000026748
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D1Smu10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,657,959 - 182,658,086 (+)MAPPERmRatBN7.2
Rnor_6.01199,494,211 - 199,494,337NCBIRnor6.0
Rnor_5.01206,521,673 - 206,521,799UniSTSRnor5.0
RGSC_v3.41187,333,197 - 187,333,323UniSTSRGSC3.4
Celera1180,307,674 - 180,307,800UniSTS
Cytogenetic Map1q36UniSTS
D1Got166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,657,961 - 182,658,182 (+)MAPPERmRatBN7.2
Rnor_6.01199,494,213 - 199,494,433NCBIRnor6.0
Rnor_5.01206,521,675 - 206,521,895UniSTSRnor5.0
RGSC_v3.41187,333,198 - 187,333,419RGDRGSC3.4
RGSC_v3.41187,333,199 - 187,333,419UniSTSRGSC3.4
Celera1180,307,676 - 180,307,896UniSTS
RGSC_v3.11187,483,080 - 187,483,300RGD
RH 2.0 Map1974.9RGD
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
275 156 726 1578 4017 975 1691 117 838 489 820 145 5220 2557 449 3935 38 1291 707 908 154 152

Sequence


Ensembl Acc Id: ENSRNOT00000026748   ⟹   ENSRNOP00000026748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,089,542 - 192,139,935 (+)Ensembl
mRatBN7.2 Ensembl1182,660,679 - 182,709,503 (+)Ensembl
Rnor_6.0 Ensembl1199,495,427 - 199,545,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085336   ⟹   ENSRNOP00000071107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1199,596,024 - 199,623,670 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086003   ⟹   ENSRNOP00000073093
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,089,542 - 192,139,935 (+)Ensembl
mRatBN7.2 Ensembl1182,659,000 - 182,709,503 (+)Ensembl
Rnor_6.0 Ensembl1199,495,298 - 199,623,960 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093862   ⟹   ENSRNOP00000088977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,089,542 - 192,139,935 (+)Ensembl
mRatBN7.2 Ensembl1182,659,000 - 182,709,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111931   ⟹   ENSRNOP00000082821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,091,127 - 192,139,943 (+)Ensembl
mRatBN7.2 Ensembl1182,660,679 - 182,709,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117515   ⟹   ENSRNOP00000077846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,091,615 - 192,139,943 (+)Ensembl
mRatBN7.2 Ensembl1182,661,167 - 182,709,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129403   ⟹   ENSRNOP00000101015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,089,542 - 192,139,935 (+)Ensembl
RefSeq Acc Id: NM_012711   ⟹   NP_036843
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,089,592 - 192,139,943 (+)NCBI
mRatBN7.21182,659,144 - 182,709,501 (+)NCBI
Dahl_SR_JrHsd1191,405,241 - 191,449,619 (+)NCBI
Lyon_Normotensive1196,407,414 - 196,451,794 (+)NCBI
Lyon_Hypertensive1193,074,965 - 193,119,348 (+)NCBI
F344_StmMcwi1191,365,191 - 191,409,582 (+)NCBI
Rnor_6.01199,495,427 - 199,545,292 (+)NCBI
Rnor_5.01206,522,794 - 206,573,619 (+)NCBI
RGSC_v3.41187,334,413 - 187,385,583 (+)RGD
Celera1180,308,890 - 180,355,319 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230214   ⟹   XP_006230276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,089,496 - 192,139,947 (+)NCBI
mRatBN7.21182,659,047 - 182,709,495 (+)NCBI
Rnor_6.01199,495,312 - 199,545,738 (+)NCBI
Rnor_5.01206,522,794 - 206,573,619 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036843   ⟸   NM_012711
- Peptide Label: precursor
- UniProtKB: Q9JI30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230276   ⟸   XM_006230214
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4L8 (UniProtKB/TrEMBL),   Q9JI30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026748   ⟸   ENSRNOT00000026748
Ensembl Acc Id: ENSRNOP00000071107   ⟸   ENSRNOT00000085336
Ensembl Acc Id: ENSRNOP00000073093   ⟸   ENSRNOT00000086003
Ensembl Acc Id: ENSRNOP00000077846   ⟸   ENSRNOT00000117515
Ensembl Acc Id: ENSRNOP00000082821   ⟸   ENSRNOT00000111931
Ensembl Acc Id: ENSRNOP00000088977   ⟸   ENSRNOT00000093862
Ensembl Acc Id: ENSRNOP00000101015   ⟸   ENSRNOT00000129403
Protein Domains
VWFA

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690468
Promoter ID:EPDNEW_R976
Type:initiation region
Name:Itgad_1
Description:integrin subunit alpha D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,495,350 - 199,495,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2926 AgrOrtholog
BioCyc Gene G2FUF-57313 BioCyc
Ensembl Genes ENSRNOG00000019728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026748 ENTREZGENE
  ENSRNOT00000026748.6 UniProtKB/TrEMBL
  ENSRNOT00000086003 ENTREZGENE
  ENSRNOT00000086003.3 UniProtKB/TrEMBL
  ENSRNOT00000093862.2 UniProtKB/TrEMBL
  ENSRNOT00000111931.2 UniProtKB/TrEMBL
  ENSRNOT00000117515.2 UniProtKB/TrEMBL
  ENSRNOT00000129403.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:25021 UniProtKB/TrEMBL
NCBI Gene 25021 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-M UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen Itgam PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019728 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A0G2K4L8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8A4_RAT UniProtKB/TrEMBL
  A0A8I5ZVY4_RAT UniProtKB/TrEMBL
  A0A8I6A686_RAT UniProtKB/TrEMBL
  A0ABK0KZS1_RAT UniProtKB/TrEMBL
  G3V8L7_RAT UniProtKB/TrEMBL
  Q9JI30 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Itgam  integrin subunit alpha M  Itgam  integrin, alpha M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgam  integrin, alpha M  Itgam  integrin alpha M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itgam  Integrin alpha-M      Symbol and Name status set to approved 70586 APPROVED