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Gene: Itgam (integrin alpha M) Mus musculus
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Symbol: Itgam
Name: integrin alpha M
Description: Exhibits complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; leukocyte migration; and positive regulation of neuron death. Localizes to the external side of plasma membrane; integrin alphaM-beta2 complex; and nucleus. Human ortholog(s) of this gene implicated in lupus nephritis. Is expressed in several structures, including central nervous system; heart; renal interstitium; thymus; and yolk sac. Orthologous to human ITGAM (integrin subunit alpha M); PARTICIPATES IN integrin mediated signaling pathway; Entamoebiasis pathway; Leishmaniasis pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD11 antigen-like family member B; Cd11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3; CR3A; F730045J24Rik; integrin alpha-M; leukocyte adhesion receptor MO1; Ly-40; Mac-1; Mac-1 alpha; Mac-1a; MAC1; macrophage antigen alpha
Orthologs:
Homo sapiens (human) : ITGAM (integrin subunit alpha M)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgam (integrin subunit alpha M)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgam (integrin subunit alpha M)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAM (integrin subunit alpha M)
Canis lupus familiaris (dog) : ITGAM (integrin subunit alpha M)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgam (integrin subunit alpha M)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIGRCm37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBImm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7 F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itgam
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732433
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.