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Gene: Itgam (integrin alpha M) Mus musculus
Symbol: Itgam
Name: integrin alpha M
Description: Exhibits complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; leukocyte migration; and positive regulation of neuron death. Localizes to the external side of plasma membrane; integrin alphaM-beta2 complex; and nucleus. Human ortholog(s) of this gene implicated in lupus nephritis. Is expressed in several structures, including central nervous system; heart; renal interstitium; thymus; and yolk sac. Orthologous to human ITGAM (integrin subunit alpha M); PARTICIPATES IN integrin mediated signaling pathway; Entamoebiasis pathway; Leishmaniasis pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD11 antigen-like family member B; Cd11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; CR3; CR3A; F730045J24Rik; integrin alpha-M; leukocyte adhesion receptor MO1; Ly-40; Mac-1; Mac-1 alpha; Mac-1a; MAC1; macrophage antigen alpha
Homo sapiens (human) : ITGAM (integrin subunit alpha M)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgam (integrin subunit alpha M)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgam (integrin subunit alpha M)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGAM (integrin subunit alpha M)
Canis lupus familiaris (dog) : ITGAM (integrin subunit alpha M)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgam (integrin subunit alpha M)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIGRCm37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBImm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7 F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itgam
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732433
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.