Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

INTEGRIN MEDIATED SIGNALING PATHWAY (PW:0000286)

View Ontology Report

Description

Integrin mediated signaling involves cell-cell and cell-extracellular matrix (ECM) specific protein interactions. Integrin alpha and beta subunits form the approximately 24 known pairs of receptor heterodimer complexes. In the absence of stimuli the receptors are in a low-affinity ligand binding state - the 'bent' conformation. Structural re-arrangements triggered by agonists give rise to the 'extended', high-affinity ligand binding state. Integrin mediated signaling is bi-directional: binding o

Pathway Diagram:

Ariadne Genomics Inc. Itgb1bp1 ---- Krit1 Tln1 Itga Itga ---- Sharpin Fabp3 ---- Itga Fblim1 ---- filamins cell motility cell differentiation cell proliferation cell survival PIP2 Fblim1 ---| filamins kindlins (Fermt) Ilk Sharpin ---| Itgb Fabp3 Sharpin Fabp3 ---| Itgb Itgb Fblim1 Krit1 Itgb1bp1 ---| Itgb Itgb ---- Itgb1bp1 Itgb1bp1 filamins ---| Itgb filamins ---- Itgb Itgb ---> invasion Ptk2 RTK, others Itgb ---- Tln1 Itgb ---- Tln2 kindlins (Fermt) --+> Itgb Itgb ---- kindlins (Fermt) Itga ---> cell adhesion Itga ---> invasion invasion Ilk ---- Parvb Parva ---- Pxn Nck2 ---- RTK, others Ilk ---- Lims1 Ilk ---- Pxn Ilk ---- Parva Lims1 ---- Nck2 Ptk2 ---- RTK, others Ptk2 ---- Tln1 Ilk ---- Parvg Apbb1ip ---- Tln2 Apbb1ip ---- Tln1 Tln1 --+> Itgb Tln2 cell surface proteins Itgb ---> cell migration Itga ---> cell migration Itga ---> ECM assembly Itgb ---> ECM assembly RTK, others ---> invasion ECM assembly cell migration ECM proteins cell adhesion Itgb ---> cell adhesion Krit1 ---| Itgb1bp1 Tln2 --+> Itgb Pxn Ptk2 ---- Pxn Ilk ---- Lims2 Lims2 Lims1 Ilkap Ilkap ---| Ilk Parvb Parva Parvg Apbb1ip Nck2 Ilk ---- Itgb filamins
GO TO:

Genes in Pathway:


show annotations for term's descendants           Sort by:
integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr17:84,941,404...85,033,020
Ensembl chr17:84,982,243...85,033,010
JBrowse link
G Fabp3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fblim1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757
JBrowse link
G Fermt1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555
JBrowse link
G Fermt2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811
JBrowse link
G Fermt3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587
JBrowse link
G Flna filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Flnb filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
JBrowse link
G Flnc filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
JBrowse link
G Ilk integrin-linked kinase ISO
IMP
RGD PMID:16493410 PMID:8538749 PMID:12629168 RGD:2300344, RGD:40924646, RGD:2302091 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
JBrowse link
G Itga1 integrin subunit alpha 1 ISS
ISO
RGD PMID:2380249 PMID:17543136 RGD:729264, RGD:5135538 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itga10 integrin subunit alpha 10 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172
JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
JBrowse link
G Itga2 integrin subunit alpha 2 TAS
ISO
RGD PMID:12941079 PMID:17543136 RGD:1302878, RGD:5135538 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga2b integrin subunit alpha 2b ISO based on Entrez HomoloGene, BLAST RGD PMID:17543136 RGD:5135538 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
JBrowse link
G Itga4 integrin subunit alpha 4 TAS
ISO
RGD PMID:11782963 PMID:17543136 RGD:1302879, RGD:5135538 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga5 integrin subunit alpha 5 IDA
ISO
RGD PMID:12821041 PMID:17543136 RGD:1300196, RGD:5135538 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itga6 integrin subunit alpha 6 ISS
ISO
RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itga7 integrin subunit alpha 7 IDA
ISO
RGD PMID:1315319 PMID:17543136 RGD:70774, RGD:5135538 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450
JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:17543136 PMID:9054500 RGD:5135538, RGD:40903006 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
JBrowse link
G Itgad integrin subunit alpha D ISS
ISO
RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:182,759,762...182,788,422
Ensembl chr 1:182,759,740...182,788,161
JBrowse link
G Itgae integrin subunit alpha E TAS
ISO
RGD PMID:9394838 PMID:17543136 RGD:633077, RGD:5135538 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093
JBrowse link
G Itgal integrin subunit alpha L ISS
ISO
RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgam integrin subunit alpha M ISO RGD PMID:34630381 PMID:17543136 RGD:329849126, RGD:5135538 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgav integrin subunit alpha V ISO
IDA
RGD PMID:12297042 PMID:17543136 PMID:12639933 RGD:1358329, RGD:5135538, RGD:1625134 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgax integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Itgb1 integrin subunit beta 1 ISS
ISO
IDA
RGD PMID:9633916 PMID:17543136 PMID:12639933 RGD:1302874, RGD:5135538, RGD:1625134 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Itgb3 integrin subunit beta 3 ISS
ISO
IDA
RGD PMID:12600920 PMID:17543136 PMID:12639933 RGD:633129, RGD:5135538, RGD:1625134 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Itgb4 integrin subunit beta 4 TAS
ISO
RGD PMID:8026337 PMID:17543136 RGD:729025, RGD:5135538 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Itgb5 integrin subunit beta 5 ISO RGD PMID:17543136 PMID:8799848 RGD:5135538, RGD:41410438 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO
RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Itgb7 integrin subunit beta 7 TAS
ISO
RGD PMID:9233649 PMID:17543136 RGD:633040, RGD:5135538 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876
JBrowse link
G Itgb8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Krit1 KRIT1, ankyrin repeat containing ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359
JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500
JBrowse link
G Lims2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137
JBrowse link
G Nck2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Parva parvin, alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr 1:166,547,142...166,704,958
Ensembl chr 1:166,547,132...166,704,950
JBrowse link
G Parvb parvin, beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:115,360,254...115,445,767
Ensembl chr 7:115,360,261...115,445,766
JBrowse link
G Parvg parvin, gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:115,456,183...115,475,707
Ensembl chr 7:115,456,209...115,475,104
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Pxn paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955
JBrowse link
G Tln1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340, RGD:7349373 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
JBrowse link
G Tln2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238
JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO
RGD PMID:11782963 PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Groupfilaminsfilamin activators
Functional ClassItgaintegrin alpha subunit
Functional ClassItgbintegrin beta subunit
Gene Groupkindlins (Fermt)kindlin activators

Pathway Gene Annotations

Disease Annotations Associated with Genes in the integrin mediated signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmItgam , Itgav
acromesomelic dysplasia, Maroteaux typeTln1
Acute Coronary SyndromeItgb3
Acute Lung InjuryItgam , Itgb2
acute myeloid leukemiaFermt2 , Fermt3 , Itgav , Itgb3
acute myocardial infarctionItgam
acute promyelocytic leukemiaItgal , Itgam , Itgax , Itgb2
acute retinal necrosis syndromeItga2
adenoid cystic carcinomaItgb4
adrenoleukodystrophyFlna
AlbuminuriaNck2
alkaptonuriaItgb5
allergic contact dermatitisItgam
allergic diseaseItgb2
allergic rhinitisItgb2
Alveolar Bone LossItgav
Alzheimer's diseaseFabp3 , Nck2
amelogenesis imperfecta type 1HItgb6
anauxetic dysplasiaTln1
anemiaItga3
AneurysmFlna
Angiokeratoma Corporis Diffusum with Arteriovenous FistulasKrit1
angle-closure glaucomaFermt2
anti-basement membrane glomerulonephritisItga4
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisItgam
aortic aneurysmFlna
arrhythmogenic right ventricular cardiomyopathyFlnc
Arterial Occlusive DiseasesItgb3
Arterial ThrombosisFlna
arterial tortuosity syndromeFlna
arteriosclerosisItga1 , Itga2 , Itga7 , Itgb3
asthmaItgb3 , Itgb6
Atelosteogenesis Type 1Flnb
Atelosteogenesis Type 3Flnb
atherosclerosisItgam
atopic dermatitisSharpin
atrial fibrillationItgam , Ptk2
AtrophyFermt1
autism spectrum disorderItga4 , Itgb3
autistic disorderFlna , Itga4 , Itgb2 , Itgb3 , Itgb6 , Ptk2
autoimmune diseaseItgb6
autoimmune polyendocrine syndrome type 1Itgb2
autoimmune thrombocytopenic purpuraItgb3
autosomal dominant distal hereditary motor neuronopathy 7Lims1
autosomal dominant limb-girdle muscular dystrophy type 2Flnc
autosomal dominant polycystic kidney diseaseItga8
autosomal dominant thrombophilia due to protein C deficiencyLims2
autosomal recessive distal hereditary motor neuronopathy 2Tln1
autosomal recessive limb-girdle muscular dystrophy type 2WLims2
B-Cell Chronic Lymphocytic LeukemiaItga4
bacterial pneumoniaItgb3
Banti's SyndromeItgb3
Barth syndromeFlna
Behcet's diseaseItga2 , Itgal , Itgam , Itgb2
Bethlem Myopathy 1AIlkap
blood platelet diseaseFermt3
Bloom syndromeItga11 , Tln2
bone development diseaseFlnb , Itgb1bp1
Boomerang dysplasiaFlnb
Brain DeathItgam
brain ischemiaItgam
Brain NeoplasmsItgb2
branched-chain keto acid dehydrogenase kinase deficiencyItgad , Itgam , Itgax
breast cancerItga1
Breast NeoplasmsFlna , Ptk2
Bronchial HyperreactivityItgb3
bronchopulmonary dysplasiaItga3
Brown-Vialetto-Van Laere syndrome 2Sharpin
Brugada syndromeItga9
BurnsItgam
calcinosisItgb1 , Itgb2
Canavan diseaseItgae
capillary leak syndromeTln1
Cardiac ArrhythmiasItga2
CardiomegalyItga3
cardiomyopathyFlnc , Ilk , Itga7 , Itgb1
Carotid Artery InjuriesItgav , Itgb3
carotid artery thrombosisItga2b , Itgb3
carotid stenosisItgb3
cataract 9 multiple typesItgb2
cavernous hemangiomaKrit1
Cavernous Malformations of CNS and RetinaKrit1
centronuclear myopathy 2Lims2
cerebellar ataxiaTln1
cerebral cavernous malformationKrit1
cerebral cavernous malformation 1Krit1
cerebral creatine deficiency syndrome 1Flna
Cerebral HemorrhageItga2b , Itgav , Itgb2 , Itgb3
cerebral infarctionItga9 , Itgam
cervical cancerPtk2
cervix carcinomaPtk2
ChloracneItgb2
cholangitisItgb6
Choroidal NeovascularizationItgav
chromosome 1p36 deletion syndromeFblim1
chromosome 2q37 deletion syndromeIlkap
Chronic Hepatitis CItgb6
Chronic PeriodontitisItgb2
chronic ulcer of skinItgb2
cleft palateFlna , Flnb
clubfootFlnb
Cocaine-Related DisordersIlk
colitisFlna , Itgb2
Colonic NeoplasmsItga7
Colonic PolypsIlk
colorectal cancerItga11 , Tln2
colorectal carcinomaItgb3
Colorectal NeoplasmsFlnc
cone-rod dystrophyItga4
congenital chylothoraxItga9
congenital heart diseaseFlna
congenital muscular dystrophy due to integrin alpha-7 deficiencyItga7
congestive heart failureItgb1
connective tissue diseaseFlna , Flnb
corneal neovascularizationItgav
coronary artery diseaseItga2
Coronary DiseaseItga2 , Itgam , Itgb3
coronary restenosisItgb2
coronary stenosisItgav
coronary thrombosisItgb3
COVID-19Itga1 , Itga7 , Itgb8
Craniofacial AbnormalitiesItgb1bp1
craniosynostosisFlna
D-2-hydroxyglutaric aciduria 1Ilkap
dermatitisItgb2 , Sharpin
developmental and epileptic encephalopathy 30Itgb2
Developmental DisabilitiesFlna
diabetes mellitusItga2
diabetic angiopathyItgam
Diabetic FootItgam
Diabetic NephropathiesItga2 , Itgb2
diabetic retinopathyItga2 , Itga4 , Itgam , Itgb3
dilated cardiomyopathyFlnc , Ilk , Itgb1
dilated cardiomyopathy 1BFlnc
disorder of sexual developmentFlna
distal arthrogryposis type 1ATln1
distal myopathy 4Flnc
Down syndromeFabp3
Duchenne muscular dystrophyItga7
ductal carcinoma in situPtk2
DwarfismFlna , Flnb
dyskeratosis congenitaFlna
ectodermal dysplasiaItgb4
ectodermal dysplasia 10ALims1
EczemaItga3
Ehlers-Danlos syndromeFlna
Ehlers-Danlos syndrome classic type 1Flna
Emery-Dreifuss muscular dystrophyFlna
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3Lims1
end stage renal diseaseItga8 , Itgb3
endometrial carcinomaPtk2
endometrial hyperplasiaPtk2
endometriosisItga2 , Itgb1 , Itgb8 , Ptk2
EndotoxemiaItga2b , Itgb3
EnterocolitisItgb2
EosinophiliaSharpin
Eosinophilic MyocarditisItgb2
epidermolysis bullosaItgb4
epidermolysis bullosa simplex with muscular dystrophySharpin
epilepsyFlna , Ilk , Krit1
Epstein-Barr virus infectious diseaseItgb2
ErythemaFermt1
esophageal atresiaItgb1
Experimental ArthritisItga4 , Itgb2 , Itgb3
Experimental Autoimmune EncephalomyelitisItga4
Experimental ColitisItga2 , Itga4
Experimental Diabetes MellitusFabp3 , Itga3 , Itgam , Itgb1 , Itgb3
Experimental Liver CirrhosisApbb1ip , Flna , Ilk , Itga2b , Itgal , Itgb1 , Itgb2 , Itgb3 , Itgb6 , Ptk2
Experimental Mammary NeoplasmsIlk , Itgb3 , Ptk2
Experimental MelanomaPxn
Experimental NeoplasmsItgav
familial hyperlipidemiaItgam
familial hypertrophic cardiomyopathyFlnc , Ilk
familial hypocalciuric hypercalcemiaItgb5
Familial Prostate CancerItgb8
Familial Sudden DeathFlna
Familial Thoracic Aortic Aneurysm 2Flna
Familial Thoracic Aortic Aneurysm 7Itgb5
favismFlna
Female InfertilityItga2
FG syndromeFlna
FG Syndrome 2Flna
focal segmental glomerulosclerosisItgb3
frontometaphyseal dysplasiaFlna
frontometaphyseal dysplasia 1Flna
frontotemporal dementia and/or amyotrophic lateral sclerosis 6Tln1
fundus dystrophyItga4
galactokinase deficiencyItgb4
galactosemiaTln1
gastroesophageal reflux diseaseItga3
Gastrointestinal HemorrhageFlna
gastrointestinal stromal tumorItga10
genetic diseaseApbb1ip , Fabp3 , Fblim1 , Fermt1 , Fermt2 , Fermt3 , Flna , Flnb , Flnc , Ilk , Ilkap , Itga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga3 , Itga4 , Itga5 , Itga6 , Itga7 , Itga8 , Itga9 , Itgad , Itgae , Itgal , Itgam , Itgav , Itgax , Itgb1 , Itgb1bp1 , Itgb2 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8 , Krit1 , Lims1 , Lims2 , Nck2 , Parva , Parvb , Parvg , Ptk2 , Pxn , Sharpin , Tln1 , Tln2
Glanzmann Thrombasthenia 1Itga2b , Itgb3
Glanzmann Thrombasthenia 2Itgb3
Glanzmann's thrombastheniaItga2 , Itga2b , Itgb3
glioblastomaPtk2
GliosisItga1 , Itga2 , Itga4 , Itga5 , Itgb1 , Itgb3 , Itgb4
glomerulonephritisItga3 , Itgam , Itgb1 , Itgb2 , Itgb3
graft-versus-host diseaseItga2
Graves' diseaseItgb3
Hantavirus hemorrhagic fever with renal syndromeItgb3
Hantavirus InfectionsItgb3
Heart BlockFlnc
heart valve diseaseItgb2
HemorrhageFermt3 , Itgb3
hemorrhagic diseaseFlna , Itga2b , Itgb3
hepatoblastomaFlna
hepatocellular carcinomaPtk2
hereditary breast ovarian cancer syndromeFlna
hereditary spastic paraplegia 30Ilkap
high grade gliomaFermt3
Hip FracturesItgb3
Hirschsprung's diseaseItgb1
holoprosencephalySharpin
homocystinuriaItgb2
Huntington's disease-like 1Fermt1
hydrocephalusItgb1
hydronephrosisFlna
HyperalgesiaItga1 , Itga2 , Itga3 , Itga5 , Itgb1
HypercholesterolemiaItgam
hyperglycemiaItgam , Itgav
hyperinsulinismItgam
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated with Cerebral Capillary MalformationsKrit1
hyperphosphatasia with impaired intellectual development syndrome 2Tln1
hypertensionFabp3 , Itga9 , Itgav , Ptk2
hypertrophic cardiomyopathyFlnc
hypertrophic cardiomyopathy 1Flnc , Ilk
hypertrophic cardiomyopathy 26Flnc
hypoparathyroidism-deafness-renal disease syndromeItga8
ileitisItgam
immunodeficiency 33Flna
InflammationItgal
inflammatory bowel diseaseItga4 , Itgal , Itgb8
Insulin ResistanceFabp3 , Itgam
intellectual disabilityFermt3 , Flna , Ilkap , Parva , Parvb , Parvg
intermediate coronary syndromeItga2 , Itgam
Invasive CandidiasisItgam
iron deficiency anemiaItga2
ischemiaItgav , Ptk2
Juberg Hayward SyndromeFlna
junctional epidermolysis bullosaItga6 , Itgb4
Junctional Epidermolysis Bullosa 5A, IntermediateItgb4
Junctional Epidermolysis Bullosa 7, with Interstitial Lung Disease and Nephrotic SyndromeItga3
junctional epidermolysis bullosa Herlitz typeItga6
junctional epidermolysis bullosa non-Herlitz typeItgb4
junctional epidermolysis bullosa with pyloric atresiaItga6 , Itgb4
juvenile rheumatoid arthritisItga2b , Itgb5
Kidney NeoplasmsItgb2
Kidney Reperfusion InjuryItgb2
Kindler syndromeFermt1
Knee DislocationFlnb
Larsen syndromeFlnb
Larsen SyndromesFlnb
Left Ventricular HypertrophyPtk2
leiomyomaPtk2
leishmaniasisItgb2
leukocyte adhesion deficiencyFermt3 , Itgb2
leukocyte adhesion deficiency 1Fermt3 , Itgb2
leukocyte adhesion deficiency 3Fermt3 , Itgb2
leukocyte diseaseItgb2
LeukocytosisItga4
limb ischemiaItgam , Itgav
liver cirrhosisItgb6
liver diseaseItgb6
Liver Reperfusion InjuryItgam
Localized Epidermolysis Bullosa Simplex 1CItgb4
long QT syndromeIlk , Krit1
lung diseaseFlna , Itgb3
Lung InjuryItgam
lung metastasisItgav
lung non-small cell carcinomaItga9 , Itgb1 , Itgb3 , Itgb4 , Pxn
lung small cell carcinomaItgb1 , Ptk2
lung squamous cell carcinomaPtk2
lupus nephritisItgam
Lupus Vasculitis, Central Nervous SystemItgam
Lymphatic MetastasisItgb1 , Ptk2
malignant mesotheliomaIlk
Marfan syndromeFlna
Melnick-Needles syndromeFlna
mesangial proliferative glomerulonephritisItga8 , Itgam
Metabolic SyndromeItgav
methylmalonic acidemia and homocysteinemia cblX typeFlna
microcephalyFlna , Itgb6
mitral valve prolapseFlna
molybdenum cofactor deficiencyItga2
molybdenum cofactor deficiency type BItga2
Mouth NeoplasmsPtk2
Muscle HypotoniaFlna
Muscle WeaknessFlnc
muscular diseaseFabp3 , Itga7
myelodysplastic syndromeItgb3
myocardial infarctionFabp3 , Itga2 , Itga3 , Itgam , Itgb1 , Itgb3
Myocardial IschemiaItgav
myocarditisItgb2
myoepitheliomaItgal , Itgb4 , Tln2
myofibrillar myopathyFlnc
myofibrillar myopathy 5Flnb , Flnc
myopiaFlna
Nasal PolypsItgal
NecrosisFabp3
Neonatal Alloimmune ThrombocytopeniaItga2 , Itga2b , Itgb3
Neoplasm InvasivenessItga5 , Itgb1 , Ptk2 , Tln1
Neoplasm MetastasisItga6 , Itgb1 , Itgb3 , Ptk2 , Pxn
Neoplastic Cell TransformationPtk2 , Pxn
nephritisItga4 , Itgal , Itgam , Itgb2 , Ptk2
nephrosisItgb2
nephrotic syndromeItga3 , Itgb4 , Nck2
Nerve DegenerationItgam
neural tube defectItgb1
NeuralgiaItgam
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESFlna
Neurodevelopmental DisordersFlna , Itga1 , Itga2 , Itgav , Itgb2
neuronal ceroid lipofuscinosisIlk , Itga11
neutropeniaItgam , Lims2
Nijmegen breakage syndromeFlna
non-arteritic anterior ischemic optic neuropathyItgb3
obesityFabp3 , Itgam
omphaloceleFlna
orofacial cleftFlna
osteochondrodysplasiaFlna , Flnb , Itga10
osteogenesis imperfecta type 1Itga3
osteopetrosisFermt3
osteoporosisTln1
otopalatodigital syndrome spectrum disorderFlna
otopalatodigital syndrome type 1Flna
otopalatodigital syndrome type 2Flna
ovarian cancerFermt3 , Ilk , Itga8
ovarian carcinomaPtk2
Ovarian NeoplasmsItga8
pancreatic cancerIlk , Itga11 , Itga4 , Itga9
pancreatitisItgb2
pantothenate kinase-associated neurodegenerationFermt1
paraplegiaFlna
parathyroid carcinomaItga10
patent foramen ovaleFlna
Pathologic ConstrictionItgb3
Penoscrotal TranspositionItga3
peritonitisItgam , Itgb2
periventricular nodular heterotopiaFlna
Periventricular Nodular Heterotopia 4Flna
persistent fetal circulation syndromeItgam
Phelan-McDermid syndromeParvb , Parvg
phimosisItga3
Phyllodes TumorFlna
placental insufficiencyItga2
Plaque, AtheroscleroticFermt3 , Itgb2 , Itgb3
platelet-type bleeding disorder 16Itga2b , Itgb3
Platelet-Type Bleeding Disorder 24Itgb3
platelet-type bleeding disorder 9Itga2
pleomorphic xanthoastrocytomaFlnc , Itgb8 , Krit1
pneumoniaItga2 , Itga4 , Itgb2 , Itgb3
Posttransfusion PurpuraItgb3
pre-eclampsiaItga4 , Itgam
primary ciliary dyskinesiaItgb2 , Tln1
Primary Lymphedema with MyelodysplasiaItgb5
progressive myoclonus epilepsyItgb2
prostate adenocarcinomaIlk
prostate cancerIlk , Itgad , Itgb6 , Ptk2
Prostatic NeoplasmsItgb3
proteinuriaNck2
prune belly syndromeFlna
psoriasisItgb2
Pulmonary Arterial HypertensionItga5
pulmonary emphysemaItgb6
pulmonary eosinophiliaItgb2
pulmonary hypertensionPtk2
Pyloric AtresiaItgb4
Pyruvate Dehydrogenase E1-Beta DeficiencyFlnb
renal agenesisItga8
Renal Hypodysplasia/Aplasia 1Itga8
Reperfusion InjuryItga2b , Itga5 , Itgb3 , Ptk2
respiratory failureItga3
restrictive cardiomyopathyFlnc
restrictive cardiomyopathy 1Flnc
Retinal NeovascularizationItgav
retinal vein occlusionItga2
retinitis pigmentosaItga4
retinitis pigmentosa 26Itga4
rheumatoid arthritisItga6 , Ptk2
Right Ventricular HypertrophyPtk2
Salivary Gland NeoplasmsItgb4
schizophreniaItga10 , Itga8
scoliosisFlna
sensorineural hearing lossItga2
SepsisItga4 , Itgam
severe acute respiratory syndromeItga2b
severe congenital encephalopathy due to MECP2 mutationFlna
Skeletal Muscle Reperfusion InjuryItgam
spastic ataxiaFlnc
Spinal Cord CompressionItgam
spinal diseaseFlnb
SplenomegalyFlna
split hand-foot malformation 5Itga6
spondylocarpotarsal synostosis syndromeFlnb
Spontaneous AbortionsItga2 , Itgb4 , Itgb6
squamous cell carcinomaItga5 , Itgb1 , Ptk2
Stomach NeoplasmsItga5 , Itga8
Streptococcus pneumoniaItgb2
StrokeFlna , Itga2 , Itga2b , Itgam , Itgav , Itgb3
substance-related disorderParva
Sudden Cardiac DeathItgb3
Sudden Hearing LossItga2
sudden infant death syndromeFlnc
syndromic X-linked intellectual disability Lubs typeFlna
systemic lupus erythematosusItgam
telangiectasisFermt1
terminal osseous dysplasiaFlna
tetralogy of FallotFlnc
thoracic aortic aneurysmFlna
thoracic diseaseIlk
thrombocytopeniaFlna , Itga2 , Itga2b , Itgb3
thrombocytopenia-absent radius syndromeItga10
Thrombocytopenic PurpuraItga2b , Itgb3
thrombosisItga2 , Itgam
Thrombotic MicroangiopathiesItgb3
thyroid gland diseaseItgb5
transient cerebral ischemiaIlk , Itgam , Itgb3
Transplant RejectionItga4
traumatic brain injuryItgb1
trichodontoosseous syndromeItga3
tuberous sclerosisFlna
type 1 diabetes mellitusItga2 , Itga4
type 2 diabetes mellitusFabp3 , Itga1 , Itga2 , Itgam
UlcerItgb3
uremiaPtk2
urinary bladder cancerFermt2
vascular dementiaKrit1
Venous ThrombosisItga2 , Itgb3
venous tributary occlusion of retinaItga2
ventricular septal defectFlna
vesiculobullous skin diseaseFermt1
Visceral Heterotaxy 4, AutosomalItga9
Vogt-Koyanagi-Harada diseaseItgb2
von Willebrand's disease 1Itga2 , Itga2b
von Willebrand's disease 2Itga2 , Itga2b
Wolff-Parkinson-White syndromeFlna , Flnc
X-linked cardiac valvular dysplasiaFlna
X-linked chronic idiopathic intestinal pseudo-obstructionFlna
Pathway Annotations Associated with Genes in the integrin mediated signaling pathway
Pathway TermsGene Symbols
abciximab pharmacodynamics pathwayItga2b , Itgb3
altered integrin mediated signaling pathwayIlk , Itga1 , Itga11 , Itga4 , Itga5 , Itga8 , Itga9 , Itgb1
altered Reelin signaling pathwayItga3 , Itgb1
arrhythmogenic right ventricular cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
calcium signaling pathway via the calcium-sensing receptorFlna
cell-extracellular matrix signaling pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
chemokine mediated signaling pathwayPtk2 , Pxn
dilated cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
E-cadherin signaling pathwayItgae , Itgb7
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaFabp3 , Ilk
endometrial cancer pathwayIlk
Entamoebiasis pathwayItgam , Itgb2 , Ptk2
ephrin - ephrin receptor bidirectional signaling axisItga2b , Itgb3 , Nck2 , Pxn
epidermal growth factor/neuregulin signaling pathwayNck2 , Ptk2 , Tln1
eptifibatide pharmacodynamics pathwayItga2b , Itgb3
glomerulonephritis pathwayItga8 , Itgb1
hypertrophic cardiomyopathy pathwayItga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga4 , Itga5 , Itga6 , Itga7 , Itga9 , Itgb1 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8
hypoxia inducible factor pathwayItgb2
insulin signaling pathwayNck2
insulin-like growth factor signaling pathwayNck2 , Pxn
integrin mediated signaling pathwayApbb1ip , Fabp3 , Fblim1 , Fermt1 , Fermt2 , Fermt3 , Flna , Flnb , Flnc , Ilk , Ilkap , Itga1 , Itga10 , Itga11 , Itga2 , Itga2b , Itga3 , Itga4 , Itga5 , Itga6 , Itga7 , Itga8 , Itga9 , Itgad , Itgae , Itgal , Itgam , Itgav , Itgax , Itgb1 , Itgb1bp1 , Itgb2 , Itgb3 , Itgb4 , Itgb5 , Itgb6 , Itgb7 , Itgb8 , Krit1 , Lims1 , Lims2 , Nck2 , Parva , Parvb , Parvg , Ptk2 , Pxn , Sharpin , Tln1 , Tln2
interleukin-23 signaling pathwayItga3
interleukin-4 signaling pathwayItgb3
Leishmaniasis pathwayItga4 , Itgam , Itgb1 , Itgb2
long term potentiationPtk2
malaria pathwayItgal , Itgb2
mitogen activated protein kinase signaling pathwayFlna , Flnb , Flnc
mTOR signaling pathwayPxn
myocardial infarction pathwayItga1 , Itga5
myocarditis pathwayItgal , Itgb2
nuclear factor kappa B signaling pathwaySharpin
pancreatic cancer pathwayIlk , Itga11 , Itga4 , Itga9
phagocytosis pathwayItga2 , Itga5 , Itgam , Itgb1 , Itgb2 , Itgb3 , Itgb5
platelet aggregation pathwayItgb3
platelet-derived growth factor signaling pathwayItgav , Itgb3 , Nck2
Reelin signaling pathwayItga3 , Itgb1 , Nck2
rheumatoid arthritis pathwayItgal , Itgb2
Rho/Rac/Cdc42 mediated signaling pathwayFlna
small cell lung carcinoma pathwayItga2 , Itga2b , Itga6 , Itgb1 , Ptk2
sphingosine 1-phosphate signaling pathwayItgav , Itgb3
Staphylococcus aureus infection pathwayItgal , Itgam , Itgb2
syndecan signaling pathwayItga2 , Itga5 , Itgb1
T cell receptor signaling pathwayNck2
tirofiban pharmacodynamics pathwayItga2b , Itgb3
toxoplasmosis pathwayItga6 , Itgb1
tuberculosis pathwayItgam , Itgax , Itgb2
tumor necrosis factor mediated signaling pathwaySharpin
vascular endothelial growth factor signaling pathwayItgav , Itgb3 , Nck2 , Ptk2 , Pxn
Wnt signaling, non-canonical pathwayFlna
Phenotype Annotations Associated with Genes in the integrin mediated signaling pathway

References Associated with the integrin mediated signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: