RGD Reference Report - Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. - Rat Genome Database

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Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation.

Authors: Mauler, Maximilian  Herr, Nadine  Schoenichen, Claudia  Witsch, Thilo  Marchini, Timoteo  Härdtner, Carmen  Koentges, Christoph  Kienle, Korbinian  Ollivier, Véronique  Schell, Maximilian  Dorner, Ludwig  Wippel, Christopher  Stallmann, Daniela  Normann, Claus  Bugger, Heiko  Walther, Paul  Wolf, Dennis  Ahrens, Ingo  Lämmermann, Tim  Ho-Tin-Noé, Benoît  Ley, Klaus  Bode, Christoph  Hilgendorf, Ingo  Duerschmied, Daniel 
Citation: Mauler M, etal., Circulation. 2019 Feb 12;139(7):918-931. doi: 10.1161/CIRCULATIONAHA.118.033942.
RGD ID: 329853774
Pubmed: PMID:30586717   (View Abstract at PubMed)
PMCID: PMC6370531   (View Article at PubMed Central)
DOI: DOI:10.1161/CIRCULATIONAHA.118.033942   (Journal Full-text)


BACKGROUND: Platelets store large amounts of serotonin that they release during thrombus formation or acute inflammation. This facilitates hemostasis and modulates the inflammatory response.
METHODS: Infarct size, heart function, and inflammatory cell composition were analyzed in mouse models of myocardial reperfusion injury with genetic and pharmacological depletion of platelet serotonin. These studies were complemented by in vitro serotonin stimulation assays of platelets and leukocytes in mice and men, and by measuring plasma serotonin levels and leukocyte activation in patients with acute coronary syndrome.
RESULTS: Platelet-derived serotonin induced neutrophil degranulation with release of myeloperoxidase and hydrogen peroxide (H2O2) and increased expression of membrane-bound leukocyte adhesion molecule CD11b, leading to enhanced inflammation in the infarct area and reduced myocardial salvage. In patients hospitalized with acute coronary syndrome, plasmatic serotonin levels correlated with CD11b expression on neutrophils and myeloperoxidase plasma levels. Long-term serotonin reuptake inhibition-reported to protect patients with depression from cardiovascular events-resulted in the depletion of platelet serotonin stores in mice. These mice displayed a reduction in neutrophil degranulation and preserved cardiac function. In line, patients with depression using serotonin reuptake inhibition, presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood.
CONCLUSIONS: Taken together, we identify serotonin as a potent therapeutic target in neutrophil-dependent thromboinflammation during myocardial reperfusion injury.

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
serotonin increases expression ISOItgam (Mus musculus)329853774; 329853774Serotonin increases expression of Itgam protein on neutrophilsRGD 
serotonin increases expression EXP 329853774Serotonin increases expression of Itgam protein on neutrophilsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Itgam  (integrin subunit alpha M)

Genes (Mus musculus)
Itgam  (integrin alpha M)

Genes (Homo sapiens)
ITGAM  (integrin subunit alpha M)


Additional Information