ITGAM (integrin subunit alpha M) - Rat Genome Database

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Gene: ITGAM (integrin subunit alpha M) Homo sapiens
Analyze
Symbol: ITGAM
Name: integrin subunit alpha M
RGD ID: 1343608
HGNC Page HGNC
Description: Exhibits heat shock protein binding activity. Involved in ectodermal cell differentiation; positive regulation of neutrophil degranulation; and positive regulation of superoxide anion generation. Localizes to cell surface; extracellular space; and plasma membrane raft. Implicated in lupus nephritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: antigen CD11b (p170); CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha M (complement component receptor 3, alpha); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; MGC117044; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1631,259,967 - 31,332,892 (+)EnsemblGRCh38hg38GRCh38
GRCh381631,259,975 - 31,332,877 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371631,271,296 - 31,344,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,178,789 - 31,251,714 (+)NCBINCBI36hg18NCBI36
Build 341631,178,811 - 31,251,691NCBI
Celera1628,953,869 - 29,026,766 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,832,071 - 28,904,704 (+)NCBIHuRef
CHM1_11632,589,199 - 32,661,884 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(S)-ropivacaine  (EXP)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-mercaptopropanoic acid  (ISO)
3-methyladenine  (EXP)
3-phenoxybenzoic acid  (EXP)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
acrylamide  (ISO)
agathisflavone  (ISO)
all-trans-4-oxoretinol  (EXP)
all-trans-retinoic acid  (EXP)
alternariol  (ISO)
ammonium chloride  (ISO)
Anacardic acid  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
Antimony trioxide  (EXP)
antirheumatic drug  (EXP)
apocynin  (EXP,ISO)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asperentin  (ISO)
atorvastatin calcium  (EXP)
auranofin  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bupivacaine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
Calcimycin  (EXP)
calciol  (EXP)
calcitriol  (EXP)
carbon nanotube  (EXP,ISO)
carnosic acid  (EXP)
chloroprene  (ISO)
chloroquine  (EXP)
choline  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP)
cypermethrin  (EXP)
DAPT  (EXP)
Deguelin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dichlorvos  (ISO)
diclofenac  (ISO)
dimemorfan  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (ISO)
disulfiram  (EXP)
dorsomorphin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
epalrestat  (ISO)
estrone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
ethylenediaminetetraacetic acid  (EXP)
everolimus  (EXP)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gefitinib  (EXP)
genistein  (ISO)
Ginkgoic acid  (EXP)
ginsenoside Rb1  (ISO)
glutathione  (EXP)
glyburide  (ISO)
GW 4064  (ISO)
halothane  (ISO)
heparin  (EXP)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
indometacin  (EXP,ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (EXP)
isoprenaline  (EXP)
kaempferol  (EXP)
kainic acid  (ISO)
KT 5720  (EXP)
L-methionine  (ISO)
lactacystin  (EXP)
lead nitrate  (ISO)
leukotriene B4  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
lithocholic acid  (EXP)
LY294002  (EXP,ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
memantine  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methyllycaconitine  (ISO)
ML-7  (ISO)
Morphine-3-glucuronide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
neoechinulin A  (ISO)
nickel atom  (EXP)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (EXP)
parthenolide  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
plaunotol  (EXP)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(I:C)  (ISO)
poly(styrene)  (EXP)
progesterone  (EXP)
pyrithiamine  (ISO)
pyrithione  (EXP)
quartz  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rolipram  (EXP)
rotenone  (ISO)
rutin  (ISO)
ryanodine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sodium stibogluconate  (EXP)
Soman  (ISO)
staurosporine  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
succimer  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP)
tacrine  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tepoxalin  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
trimethyltin  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
xestospongin C  (EXP)
Y-27632  (EXP)
zileuton  (ISO)
zinc atom  (EXP)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activated T cell proliferation  (ISO)
amyloid-beta clearance  (ISS)
apoptotic signaling pathway  (ISS)
cell adhesion  (ISO,TAS)
cell surface receptor signaling pathway involved in cell-cell signaling  (ISS)
cell-cell adhesion  (ISO)
cell-cell adhesion via plasma-membrane adhesion molecules  (NAS)
cellular extravasation  (ISO)
complement-mediated synapse pruning  (ISS)
ectodermal cell differentiation  (IEP)
forebrain development  (ISS)
innate immune response  (IEA)
integrin-mediated signaling pathway  (IEA)
leukocyte adhesion to vascular endothelial cell  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
microglia development  (ISO)
microglial cell activation  (ISS)
negative regulation of dopamine metabolic process  (ISS)
neutrophil apoptotic process  (ISO)
neutrophil chemotaxis  (ISO)
phagocytosis  (ISO)
phagocytosis, engulfment  (ISS)
positive regulation of hippocampal neuron apoptotic process  (ISS)
positive regulation of mast cell differentiation  (ISO)
positive regulation of microglial cell mediated cytotoxicity  (ISS)
positive regulation of neuron death  (ISS)
positive regulation of neutrophil degranulation  (IGI)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of prostaglandin-E synthase activity  (ISS)
positive regulation of protein targeting to membrane  (ISS)
positive regulation of superoxide anion generation  (IGI,ISS)
receptor-mediated endocytosis  (ISS)
vertebrate eye-specific patterning  (ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1346576   PMID:1683702   PMID:1967280   PMID:2454931   PMID:2457584   PMID:2563162   PMID:2833753   PMID:3284962   PMID:3539202   PMID:4062888   PMID:7867070   PMID:8419480  
PMID:8458080   PMID:8573344   PMID:8747460   PMID:9142045   PMID:9175709   PMID:9211902   PMID:9488691   PMID:9558116   PMID:9560195   PMID:9569238   PMID:9687375   PMID:9712878  
PMID:9844058   PMID:10352278   PMID:10744708   PMID:10748078   PMID:10846180   PMID:10899906   PMID:10946284   PMID:11073102   PMID:11701612   PMID:11843895   PMID:11881155   PMID:11893077  
PMID:11937770   PMID:11941318   PMID:11953106   PMID:11967116   PMID:12009501   PMID:12036876   PMID:12042322   PMID:12107753   PMID:12145463   PMID:12165526   PMID:12208882   PMID:12234260  
PMID:12244179   PMID:12377763   PMID:12377937   PMID:12390020   PMID:12393547   PMID:12393719   PMID:12444150   PMID:12466503   PMID:12477932   PMID:12485936   PMID:12495676   PMID:12496435  
PMID:12516552   PMID:12576754   PMID:12600815   PMID:12665127   PMID:12682255   PMID:12694184   PMID:12731070   PMID:12760968   PMID:12816955   PMID:12847278   PMID:12960243   PMID:14532278  
PMID:14751053   PMID:14769799   PMID:15004192   PMID:15073035   PMID:15194813   PMID:15217824   PMID:15277376   PMID:15294914   PMID:15304494   PMID:15454120   PMID:15485828   PMID:15489334  
PMID:15585684   PMID:15615722   PMID:15641787   PMID:15718918   PMID:15730520   PMID:15741160   PMID:15778383   PMID:15976367   PMID:16037628   PMID:16239529   PMID:16246332   PMID:16249234  
PMID:16260637   PMID:16357311   PMID:16389569   PMID:16508260   PMID:16614246   PMID:16782049   PMID:16915040   PMID:17172930   PMID:17202372   PMID:17202407   PMID:17228360   PMID:17346796  
PMID:17372166   PMID:17445870   PMID:17721605   PMID:17927697   PMID:17957461   PMID:18029348   PMID:18065787   PMID:18096476   PMID:18156711   PMID:18164590   PMID:18204098   PMID:18204446  
PMID:18204448   PMID:18375764   PMID:18414903   PMID:18495781   PMID:18496641   PMID:18509085   PMID:18541300   PMID:18617697   PMID:18644795   PMID:18676132   PMID:18678668   PMID:18684982  
PMID:18685529   PMID:18714035   PMID:18762778   PMID:18842294   PMID:18941116   PMID:19052753   PMID:19073595   PMID:19086264   PMID:19110536   PMID:19129174   PMID:19135988   PMID:19165918  
PMID:19234460   PMID:19246218   PMID:19250688   PMID:19286673   PMID:19387459   PMID:19480860   PMID:19546439   PMID:19550115   PMID:19572148   PMID:19578722   PMID:19587009   PMID:19747912  
PMID:19748962   PMID:19800635   PMID:19811837   PMID:19833726   PMID:19863185   PMID:19913121   PMID:19939855   PMID:20185670   PMID:20190138   PMID:20199584   PMID:20228269   PMID:20423844  
PMID:20483667   PMID:20580686   PMID:20628086   PMID:20629846   PMID:20665668   PMID:20666624   PMID:20706761   PMID:20800911   PMID:20824631   PMID:20826754   PMID:20848568   PMID:20881011  
PMID:20962850   PMID:21068098   PMID:21135163   PMID:21151989   PMID:21193407   PMID:21252155   PMID:21263017   PMID:21273385   PMID:21362770   PMID:21403131   PMID:21408207   PMID:21454473  
PMID:21551251   PMID:21571730   PMID:21610569   PMID:21676865   PMID:21840425   PMID:21874872   PMID:22017400   PMID:22052909   PMID:22053606   PMID:22095715   PMID:22145905   PMID:22229891  
PMID:22251373   PMID:22552879   PMID:22586164   PMID:22722613   PMID:22893614   PMID:23092917   PMID:23134465   PMID:23154389   PMID:23184931   PMID:23257917   PMID:23269830   PMID:23273568  
PMID:23334594   PMID:23376485   PMID:23398146   PMID:23451151   PMID:23452299   PMID:23469114   PMID:23479224   PMID:23514737   PMID:23533145   PMID:23573259   PMID:23671673   PMID:23686079  
PMID:23708937   PMID:23720274   PMID:23727038   PMID:23740937   PMID:23753600   PMID:23754403   PMID:23812215   PMID:23874603   PMID:23880611   PMID:23918739   PMID:23981064   PMID:24210817  
PMID:24264377   PMID:24269694   PMID:24373176   PMID:24608226   PMID:24623722   PMID:24726062   PMID:24782118   PMID:24829201   PMID:24871463   PMID:24886912   PMID:24945596   PMID:25005557  
PMID:25024378   PMID:25136078   PMID:25231265   PMID:25238263   PMID:25305756   PMID:25315704   PMID:25365491   PMID:25461401   PMID:25554420   PMID:25613106   PMID:25645918   PMID:25655529  
PMID:25678086   PMID:25826119   PMID:25971554   PMID:26036990   PMID:26170143   PMID:26293614   PMID:26306739   PMID:26309131   PMID:26361072   PMID:26411420   PMID:26422753   PMID:26512111  
PMID:26763077   PMID:26773105   PMID:26852488   PMID:27178742   PMID:27384580   PMID:27460017   PMID:27534550   PMID:27606963   PMID:28073885   PMID:28183849   PMID:28263189   PMID:28292891  
PMID:28398520   PMID:28669815   PMID:28807980   PMID:28939773   PMID:29049725   PMID:29120575   PMID:29207897   PMID:29424023   PMID:29540475   PMID:29575196   PMID:29632532   PMID:30041578  
PMID:30097533   PMID:30397336   PMID:30498196   PMID:30619243   PMID:30689427   PMID:30712924   PMID:30769810   PMID:30967528   PMID:31211819   PMID:31227791   PMID:31541017   PMID:31733719  
PMID:31774828   PMID:31852826   PMID:31907993   PMID:32296183   PMID:32382571   PMID:32693110   PMID:33104706   PMID:33305306  


Genomics

Comparative Map Data
ITGAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1631,259,967 - 31,332,892 (+)EnsemblGRCh38hg38GRCh38
GRCh381631,259,975 - 31,332,877 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371631,271,296 - 31,344,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,178,789 - 31,251,714 (+)NCBINCBI36hg18NCBI36
Build 341631,178,811 - 31,251,691NCBI
Celera1628,953,869 - 29,026,766 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,832,071 - 28,904,704 (+)NCBIHuRef
CHM1_11632,589,199 - 32,661,884 (+)NCBICHM1_1
Itgam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,661,812 - 127,717,663 (+)NCBIGRCm39mm39
GRCm39 Ensembl7127,661,812 - 127,717,663 (+)Ensembl
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,062,640 - 128,118,491 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIGRCm37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBImm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7F3NCBI
Itgam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,659,047 - 182,709,495 (+)NCBI
Rnor_6.0 Ensembl1199,495,298 - 199,623,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01199,495,312 - 199,545,738 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01206,522,794 - 206,573,619 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,334,413 - 187,385,583 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,484,293 - 187,535,464 (+)NCBI
Celera1180,308,890 - 180,355,319 (+)NCBICelera
Cytogenetic Map1q37NCBI
Itgam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,116,834 - 8,260,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,116,886 - 8,160,806 (+)NCBIChiLan1.0ChiLan1.0
ITGAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11631,630,983 - 31,702,406 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,630,146 - 31,702,406 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01623,634,476 - 23,707,147 (-)NCBIMhudiblu_PPA_v0panPan3
ITGAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,944,062 - 16,996,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,808,971 - 16,996,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,516,000 - 18,571,559 (-)NCBI
ROS_Cfam_1.0617,068,771 - 17,127,224 (-)NCBI
UMICH_Zoey_3.1616,871,848 - 16,927,654 (-)NCBI
UNSW_CanFamBas_1.0616,791,010 - 16,846,822 (-)NCBI
UU_Cfam_GSD_1.0617,102,490 - 17,158,038 (-)NCBI
Itgam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,528,028 - 125,576,877 (+)NCBI
SpeTri2.0NW_0049365438,460,526 - 8,508,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,136,161 - 17,273,657 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,216,719 - 17,272,134 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,651,478 - 17,668,230 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3pNCBI
ITGAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,957,162 - 28,042,697 (+)NCBI
ChlSab1.1 Ensembl527,957,324 - 28,042,691 (+)Ensembl
Vero_WHO_p1.0NW_0236660681,400,356 - 1,493,976 (-)NCBI
Itgam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478214,316,505 - 14,367,841 (+)NCBI

Position Markers
D16S753  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,273,504 - 31,273,772UniSTSGRCh37
Build 361631,181,005 - 31,181,273RGDNCBI36
Celera1629,024,285 - 29,024,549RGD
Cytogenetic Map16q21UniSTS
Cytogenetic Map16p11.2UniSTS
HuRef1628,834,287 - 28,834,547UniSTS
Marshfield Genetic Map1657.79UniSTS
Marshfield Genetic Map1657.79RGD
deCODE Assembly Map1656.8UniSTS
RH79892  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,343,075 - 31,343,269UniSTSGRCh37
Build 361631,250,576 - 31,250,770RGDNCBI36
Celera1628,954,813 - 28,955,007RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,903,566 - 28,903,760UniSTS
GDB:180920  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371631,343,042 - 31,343,440UniSTSGRCh37
Build 361631,250,543 - 31,250,941RGDNCBI36
Celera1628,954,642 - 28,955,040RGD
Cytogenetic Map16p11.2UniSTS
HuRef1628,903,533 - 28,903,931UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2449
Count of miRNA genes:1005
Interacting mature miRNAs:1203
Transcripts:ENST00000287497, ENST00000544665, ENST00000561838, ENST00000565142, ENST00000567031, ENST00000567178, ENST00000569746, ENST00000570242
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 2
Medium 276 1094 117 47 1315 33 713 123 370 56 103 652 16 767 298 1
Low 2050 1836 1572 562 531 413 3352 1880 3089 312 1252 778 152 1 437 2373 5 2
Below cutoff 68 59 29 12 60 15 255 176 222 45 79 110 5 117

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_950796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA436312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH004143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY187247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY187248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM194233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA738583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC458577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000544665   ⟹   ENSP00000441691
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,259,975 - 31,332,877 (+)Ensembl
RefSeq Acc Id: ENST00000561838
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,324,678 - 31,326,968 (+)Ensembl
RefSeq Acc Id: ENST00000565142   ⟹   ENSP00000461850
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,330,380 - 31,331,536 (+)Ensembl
RefSeq Acc Id: ENST00000567031   ⟹   ENSP00000454568
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,275,592 - 31,324,439 (+)Ensembl
RefSeq Acc Id: ENST00000567178
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,328,037 - 31,329,905 (+)Ensembl
RefSeq Acc Id: ENST00000569746
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,329,002 - 31,330,052 (+)Ensembl
RefSeq Acc Id: ENST00000570242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,271,885 - 31,273,684 (+)Ensembl
RefSeq Acc Id: ENST00000648685   ⟹   ENSP00000496959
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1631,259,967 - 31,332,892 (+)Ensembl
RefSeq Acc Id: NM_000632   ⟹   NP_000623
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,332,877 (+)NCBI
GRCh371631,271,288 - 31,344,213 (+)ENTREZGENE
Build 361631,178,789 - 31,251,714 (+)NCBI Archive
HuRef1628,832,071 - 28,904,704 (+)ENTREZGENE
CHM1_11632,589,199 - 32,661,884 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001145808   ⟹   NP_001139280
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,332,877 (+)NCBI
GRCh371631,271,288 - 31,344,213 (+)ENTREZGENE
HuRef1628,832,071 - 28,904,704 (+)ENTREZGENE
CHM1_11632,589,199 - 32,661,884 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721045   ⟹   XP_006721108
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,321,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545850   ⟹   XP_011544152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,265,396 - 31,332,869 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011545851   ⟹   XP_011544153
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,324,527 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023216   ⟹   XP_016878705
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,328,212 (+)NCBI
Sequence:
RefSeq Acc Id: XR_950796
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,332,869 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_000623 (Get FASTA)   NCBI Sequence Viewer  
  NP_001139280 (Get FASTA)   NCBI Sequence Viewer  
  XP_006721108 (Get FASTA)   NCBI Sequence Viewer  
  XP_011544152 (Get FASTA)   NCBI Sequence Viewer  
  XP_011544153 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878705 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51960 (Get FASTA)   NCBI Sequence Viewer  
  AAA58410 (Get FASTA)   NCBI Sequence Viewer  
  AAA59491 (Get FASTA)   NCBI Sequence Viewer  
  AAA59544 (Get FASTA)   NCBI Sequence Viewer  
  AAA59903 (Get FASTA)   NCBI Sequence Viewer  
  AAB24821 (Get FASTA)   NCBI Sequence Viewer  
  AAH96346 (Get FASTA)   NCBI Sequence Viewer  
  AAH96347 (Get FASTA)   NCBI Sequence Viewer  
  AAH96348 (Get FASTA)   NCBI Sequence Viewer  
  AAH99660 (Get FASTA)   NCBI Sequence Viewer  
  BAG54538 (Get FASTA)   NCBI Sequence Viewer  
  BBI36805 (Get FASTA)   NCBI Sequence Viewer  
  BBI36806 (Get FASTA)   NCBI Sequence Viewer  
  BBI36807 (Get FASTA)   NCBI Sequence Viewer  
  BBI36808 (Get FASTA)   NCBI Sequence Viewer  
  BBI36809 (Get FASTA)   NCBI Sequence Viewer  
  BBI36810 (Get FASTA)   NCBI Sequence Viewer  
  BBI36811 (Get FASTA)   NCBI Sequence Viewer  
  BBI36812 (Get FASTA)   NCBI Sequence Viewer  
  BBI36813 (Get FASTA)   NCBI Sequence Viewer  
  BBI36814 (Get FASTA)   NCBI Sequence Viewer  
  BBI36815 (Get FASTA)   NCBI Sequence Viewer  
  BBI36816 (Get FASTA)   NCBI Sequence Viewer  
  BBI36817 (Get FASTA)   NCBI Sequence Viewer  
  BBI36818 (Get FASTA)   NCBI Sequence Viewer  
  BBI36819 (Get FASTA)   NCBI Sequence Viewer  
  BBI36820 (Get FASTA)   NCBI Sequence Viewer  
  BBI36821 (Get FASTA)   NCBI Sequence Viewer  
  BBI36822 (Get FASTA)   NCBI Sequence Viewer  
  BBI36823 (Get FASTA)   NCBI Sequence Viewer  
  BBI36824 (Get FASTA)   NCBI Sequence Viewer  
  BBI36825 (Get FASTA)   NCBI Sequence Viewer  
  BBI36826 (Get FASTA)   NCBI Sequence Viewer  
  BBI36827 (Get FASTA)   NCBI Sequence Viewer  
  BBI36828 (Get FASTA)   NCBI Sequence Viewer  
  BBI36829 (Get FASTA)   NCBI Sequence Viewer  
  BBI36830 (Get FASTA)   NCBI Sequence Viewer  
  BBI36831 (Get FASTA)   NCBI Sequence Viewer  
  CCF76944 (Get FASTA)   NCBI Sequence Viewer  
  EAW52143 (Get FASTA)   NCBI Sequence Viewer  
  EAW52144 (Get FASTA)   NCBI Sequence Viewer  
  P11215 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001139280   ⟸   NM_001145808
- Peptide Label: isoform 1 precursor
- UniProtKB: P11215 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_000623   ⟸   NM_000632
- Peptide Label: isoform 2 precursor
- UniProtKB: P11215 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006721108   ⟸   XM_006721045
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011544153   ⟸   XM_011545851
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011544152   ⟸   XM_011545850
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016878705   ⟸   XM_017023216
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000496959   ⟸   ENST00000648685
RefSeq Acc Id: ENSP00000441691   ⟸   ENST00000544665
RefSeq Acc Id: ENSP00000461850   ⟸   ENST00000565142
RefSeq Acc Id: ENSP00000454568   ⟸   ENST00000567031
Protein Domains
VWFA

Promoters
RGD ID:6810954
Promoter ID:HG_ACW:30323
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ITGAM.JAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361631,172,441 - 31,172,941 (+)MPROMDB
RGD ID:6793209
Promoter ID:HG_KWN:23620
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_000632,   UC002EBR.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361631,178,521 - 31,179,021 (+)MPROMDB
RGD ID:7232091
Promoter ID:EPDNEW_H21791
Type:initiation region
Name:ITGAM_1
Description:integrin subunit alpha M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381631,259,975 - 31,260,035EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001145808.1(ITGAM):c.2164T>C (p.Cys722Arg) single nucleotide variant Malignant melanoma [RCV000071098] Chr16:31324654 [GRCh38]
Chr16:31335975 [GRCh37]
Chr16:31243476 [NCBI36]
Chr16:16p11.2
not provided
NM_000632.4(ITGAM):c.2999C>A (p.Thr1000Asn) single nucleotide variant not provided [RCV000966449]|not specified [RCV000176618] Chr16:31330103 [GRCh38]
Chr16:31341424 [GRCh37]
Chr16:16p11.2
benign
NM_000632.4(ITGAM):c.850G>A (p.Val284Ile) single nucleotide variant not provided [RCV001348877] Chr16:31273510 [GRCh38]
Chr16:31284831 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh38/hg38 16p11.2-11.1(chr16:30691912-36160463)x3 copy number gain See cases [RCV000133811] Chr16:30691912..36160463 [GRCh38]
Chr16:30703233..35147508 [GRCh37]
Chr16:30610734..35005009 [NCBI36]
Chr16:16p11.2-11.1
pathogenic
GRCh38/hg38 16p11.2(chr16:29909613-31438697)x3 copy number gain See cases [RCV000135339] Chr16:29909613..31438697 [GRCh38]
Chr16:29920934..31450018 [GRCh37]
Chr16:29828435..31357519 [NCBI36]
Chr16:16p11.2
pathogenic
GRCh38/hg38 16p12.2-11.2(chr16:23752047-31943755)x3 copy number gain See cases [RCV000141141] Chr16:23752047..31943755 [GRCh38]
Chr16:23763368..31955076 [GRCh37]
Chr16:23670869..31862577 [NCBI36]
Chr16:16p12.2-11.2
pathogenic
GRCh37/hg19 16p11.2(chr16:31154186-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207245] Chr16:31154186..31926800 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2
uncertain significance
Single allele deletion Branched-chain keto acid dehydrogenase kinase deficiency [RCV000735205] Chr16:30554158..31536880 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p11.2(chr16:31343812-31405543)x3 copy number gain See cases [RCV000445926] Chr16:31343812..31405543 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh37/hg19 16p11.2(chr16:30830287-31827011)x4 copy number gain See cases [RCV000447708] Chr16:30830287..31827011 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh37/hg19 16p11.2(chr16:28826162-29043901)x1 copy number loss See cases [RCV000448084] Chr16:28826162..29043901 [GRCh37]
Chr16:16p11.2
likely pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p11.2(chr16:31198100-31407832)x3 copy number gain See cases [RCV000512181] Chr16:31198100..31407832 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.1141T>C (p.Tyr381His) single nucleotide variant not provided [RCV000513212] Chr16:31276977 [GRCh38]
Chr16:31288298 [GRCh37]
Chr16:16p11.2
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p11.2(chr16:30738551-34194635)x3 copy number gain not provided [RCV000739123] Chr16:30738551..34194635 [GRCh37]
Chr16:16p11.2
benign
GRCh37/hg19 16p11.2(chr16:31306417-31331958)x1 copy number loss not provided [RCV000739124] Chr16:31306417..31331958 [GRCh37]
Chr16:16p11.2
benign
NM_000632.4(ITGAM):c.657G>A (p.Thr219=) single nucleotide variant not provided [RCV000917552] Chr16:31271945 [GRCh38]
Chr16:31283266 [GRCh37]
Chr16:16p11.2
benign
NM_000632.4(ITGAM):c.1944C>T (p.Ala648=) single nucleotide variant not provided [RCV000947699] Chr16:31321569 [GRCh38]
Chr16:31332890 [GRCh37]
Chr16:16p11.2
benign
NM_000632.4(ITGAM):c.2430T>C (p.Gly810=) single nucleotide variant not provided [RCV000968728] Chr16:31325329 [GRCh38]
Chr16:31336650 [GRCh37]
Chr16:16p11.2
likely benign
NM_000632.4(ITGAM):c.192C>T (p.Tyr64=) single nucleotide variant not provided [RCV000911090] Chr16:31265452 [GRCh38]
Chr16:31276773 [GRCh37]
Chr16:16p11.2
likely benign
NM_000632.4(ITGAM):c.2760G>A (p.Pro920=) single nucleotide variant not provided [RCV000957405] Chr16:31328198 [GRCh38]
Chr16:31339519 [GRCh37]
Chr16:16p11.2
benign
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p11.2(chr16:30350747-31905898)x3 copy number gain not provided [RCV001258619] Chr16:30350747..31905898 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.238+19G>A single nucleotide variant not provided [RCV001318728] Chr16:31265517 [GRCh38]
Chr16:31276838 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.2853G>T (p.Met951Ile) single nucleotide variant Systemic lupus erythematosus 6 [RCV001280970] Chr16:31329288 [GRCh38]
Chr16:31340609 [GRCh37]
Chr16:16p11.2
uncertain significance
Single allele single nucleotide variant not provided [RCV001355373] Chr16:31334604 [GRCh38]
Chr16:31345925 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.1459C>A (p.Arg487=) single nucleotide variant not provided [RCV001422464] Chr16:31297616 [GRCh38]
Chr16:31308937 [GRCh37]
Chr16:16p11.2
likely benign
NM_000632.4(ITGAM):c.1804A>T (p.Thr602Ser) single nucleotide variant not provided [RCV001301344] Chr16:31321337 [GRCh38]
Chr16:31332658 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.1984C>T (p.Arg662Trp) single nucleotide variant not provided [RCV001306394] Chr16:31321609 [GRCh38]
Chr16:31332930 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.875G>A (p.Arg292His) single nucleotide variant not provided [RCV001346464] Chr16:31275565 [GRCh38]
Chr16:31286886 [GRCh37]
Chr16:16p11.2
uncertain significance
Single allele duplication not provided [RCV001355816] Chr16:31334578..31334579 [GRCh38]
Chr16:31345899..31345900 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.2699A>G (p.Asn900Ser) single nucleotide variant not provided [RCV001314670] Chr16:31326926 [GRCh38]
Chr16:31338247 [GRCh37]
Chr16:16p11.2
uncertain significance
Single allele duplication not provided [RCV001355359] Chr16:31258303..31258304 [GRCh38]
Chr16:31269624..31269625 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.934G>A (p.Val312Met) single nucleotide variant not provided [RCV001296353] Chr16:31275624 [GRCh38]
Chr16:31286945 [GRCh37]
Chr16:16p11.2
uncertain significance
Single allele indel not provided [RCV001356291] Chr16:31257008..31257021 [GRCh38]
Chr16:31268329..31268342 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.3005A>G (p.Glu1002Gly) single nucleotide variant not provided [RCV001371958] Chr16:31330109 [GRCh38]
Chr16:31341430 [GRCh37]
Chr16:16p11.2
uncertain significance
Single allele deletion not provided [RCV001355445] Chr16:31334673..31334675 [GRCh38]
Chr16:31345994..31345996 [GRCh37]
Chr16:16p11.2
uncertain significance
NM_000632.4(ITGAM):c.558+11del deletion not provided [RCV001418241] Chr16:31271095 [GRCh38]
Chr16:31282416 [GRCh37]
Chr16:16p11.2
likely benign
NM_000632.4(ITGAM):c.444T>C (p.Asp148=) single nucleotide variant not provided [RCV001423707] Chr16:31270970 [GRCh38]
Chr16:31282291 [GRCh37]
Chr16:16p11.2
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6149 AgrOrtholog
COSMIC ITGAM COSMIC
Ensembl Genes ENSG00000169896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000441691 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000454568 UniProtKB/TrEMBL
  ENSP00000461850 UniProtKB/TrEMBL
  ENSP00000496959 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000544665 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000565142 UniProtKB/TrEMBL
  ENST00000567031 UniProtKB/TrEMBL
  ENST00000648685 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000169896 GTEx
HGNC ID HGNC:6149 ENTREZGENE
Human Proteome Map ITGAM Human Proteome Map
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha-2 UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3684 UniProtKB/Swiss-Prot
NCBI Gene 3684 ENTREZGENE
OMIM 120980 OMIM
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha2 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PharmGKB PA29949 PharmGKB
PRINTS INTEGRINA UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
  VWFA UniProtKB/Swiss-Prot
SMART Int_alpha UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot
  SSF69179 UniProtKB/Swiss-Prot
UniProt A0A3T1DF60_HUMAN UniProtKB/TrEMBL
  A0A3T1DFB0_HUMAN UniProtKB/TrEMBL
  H3BMV4_HUMAN UniProtKB/TrEMBL
  I3NI33_HUMAN UniProtKB/TrEMBL
  ITAM_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4VAK0 UniProtKB/Swiss-Prot
  Q4VAK1 UniProtKB/Swiss-Prot
  Q4VAK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 ITGAM  integrin subunit alpha M    integrin, alpha M (complement component 3 receptor 3 subunit)  Symbol and/or name change 5135510 APPROVED
2011-08-16 ITGAM  integrin, alpha M (complement component 3 receptor 3 subunit)  ITGAM  integrin, alpha M (complement component 3 receptor 3 subunit)  Symbol and/or name change 5135510 APPROVED