RGD Reference Report - Integrins: bidirectional, allosteric signaling machines. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Integrins: bidirectional, allosteric signaling machines.

Authors: Hynes, RO 
Citation: Hynes RO Cell 2002 Sep 20;110(6):673-87.
RGD ID: 1358329
Pubmed: PMID:12297042   (View Abstract at PubMed)

In their roles as major adhesion receptors, integrins signal across the plasma membrane in both directions. Recent structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways. Long-range conformational changes couple these functions via allosteric equilibria.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ITGA10Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA11Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA3Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA6Humanintegrin mediated signaling pathway   TAS  RGD 
ITGA9Humanintegrin mediated signaling pathway   TAS  RGD 
ITGADHumanintegrin mediated signaling pathway   TAS  RGD 
ITGAVHumanintegrin mediated signaling pathway   TAS  RGD 
ITGB2Humanintegrin mediated signaling pathway   TAS  RGD 
ITGB8Humanintegrin mediated signaling pathway   TAS  RGD 
Itga10Ratintegrin mediated signaling pathway   ISOITGA10 (Homo sapiens) RGD 
Itga11Ratintegrin mediated signaling pathway   ISOITGA11 (Homo sapiens) RGD 
Itga3Ratintegrin mediated signaling pathway   ISOITGA3 (Homo sapiens) RGD 
Itga3Mouseintegrin mediated signaling pathway   ISOITGA3 (Homo sapiens) RGD 
Itga6Ratintegrin mediated signaling pathway   ISS  RGD 
Itga9Ratintegrin mediated signaling pathway   ISOITGA9 (Homo sapiens) RGD 
ItgadRatintegrin mediated signaling pathway   ISS  RGD 
ItgalRatintegrin mediated signaling pathway   ISS  RGD 
ItgavRatintegrin mediated signaling pathway   ISOITGAV (Homo sapiens) RGD 
Itgb2Ratintegrin mediated signaling pathway   ISOITGB2 (Homo sapiens) RGD 
Itgb6Ratintegrin mediated signaling pathway   ISS  RGD 
Itgb8Ratintegrin mediated signaling pathway   ISOITGB8 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Itga10  (integrin subunit alpha 10)
Itga11  (integrin subunit alpha 11)
Itga3  (integrin subunit alpha 3)
Itga6  (integrin subunit alpha 6)
Itga9  (integrin subunit alpha 9)
Itgad  (integrin subunit alpha D)
Itgal  (integrin subunit alpha L)
Itgav  (integrin subunit alpha V)
Itgb2  (integrin subunit beta 2)
Itgb6  (integrin subunit beta 6)
Itgb8  (integrin subunit beta 8)

Genes (Mus musculus)
Itga3  (integrin alpha 3)

Genes (Homo sapiens)
ITGA10  (integrin subunit alpha 10)
ITGA11  (integrin subunit alpha 11)
ITGA3  (integrin subunit alpha 3)
ITGA6  (integrin subunit alpha 6)
ITGA9  (integrin subunit alpha 9)
ITGAD  (integrin subunit alpha D)
ITGAV  (integrin subunit alpha V)
ITGB2  (integrin subunit beta 2)
ITGB8  (integrin subunit beta 8)

Objects referenced in this article
Gene Itgam integrin subunit alpha M Rattus norvegicus

Additional Information