Itgal (integrin subunit alpha L) - Rat Genome Database

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Gene: Itgal (integrin subunit alpha L) Rattus norvegicus
Analyze
Symbol: Itgal
Name: integrin subunit alpha L
RGD ID: 631424
Description: Predicted to enable ICAM-3 receptor activity and integrin binding activity. Involved in cell-cell adhesion. Located in cell surface. Used to study nephritis. Orthologous to human ITGAL (integrin subunit alpha L); PARTICIPATES IN integrin mediated signaling pathway; malaria pathway; myocarditis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin alpha L; integrin alpha-L; integrin, alpha L; LFA-1; lymphocyte function-associated antigen-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,348,424 - 191,386,228 (+)NCBIGRCr8
mRatBN7.21181,918,183 - 181,955,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,918,183 - 181,955,732 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,268,740 - 190,306,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,454,828 - 197,492,382 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,123,273 - 190,161,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,744,053 - 198,781,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,744,050 - 198,781,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,742,280 - 205,780,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,561,795 - 186,598,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,716,379 - 186,726,577 (+)NCBI
Celera1179,569,739 - 179,607,287 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-naphthylamine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-Zearalanol  (EXP)
amiloride  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cerivastatin  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
diquat  (ISO)
diuron  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
etodolac  (ISO)
fentanyl  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
ginsenoside C-K  (ISO)
Heliotrine  (EXP)
hydrogen peroxide  (ISO)
isoflurane  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury(1+)  (ISO)
mifepristone  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
Senkirkine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjogrens syndrome-like MRL/lpr mice. Gao J, etal., Exp Eye Res. 2004 Apr;78(4):823-35.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
5. Intercellular adhesion molecule-1 and accumulation of eosinophils in nasal polyp tissue. Kong H, etal., Chin Med J (Engl). 1999 Apr;112(4):366-8.
6. The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver. Luo D, etal., Hepatology. 1996 Dec;24(6):1475-80.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Development of a cell-free binding assay for rat ICAM-1/LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay. Mukasa R, etal., J Immunol Methods. 1999 Aug 31;228(1-2):69-79.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
14. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. Tamatani T, etal., Eur J Immunol. 1991 Mar;21(3):627-33.
15. The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats. Wada J, etal., Nephron. 1996;73(2):264-72.
Additional References at PubMed
PMID:1346270   PMID:1448173   PMID:2477710   PMID:8043862   PMID:8117278   PMID:8557754   PMID:8562500   PMID:11812992   PMID:12477932   PMID:12652296   PMID:15064761   PMID:15210787  
PMID:19029120   PMID:19234460   PMID:19946888   PMID:20458337   PMID:20516718   PMID:23793062   PMID:23981064   PMID:30961664  


Genomics

Comparative Map Data
Itgal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,348,424 - 191,386,228 (+)NCBIGRCr8
mRatBN7.21181,918,183 - 181,955,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,918,183 - 181,955,732 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1190,268,740 - 190,306,294 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,454,828 - 197,492,382 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,123,273 - 190,161,047 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,744,053 - 198,781,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,744,050 - 198,781,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,742,280 - 205,780,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,561,795 - 186,598,908 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,716,379 - 186,726,577 (+)NCBI
Celera1179,569,739 - 179,607,287 (+)NCBICelera
Cytogenetic Map1q37NCBI
ITGAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,472,742 - 30,523,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,472,658 - 30,523,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,484,063 - 30,534,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,391,572 - 30,442,007 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,391,571 - 30,442,006NCBI
Celera1629,763,904 - 29,814,478 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,046,747 - 28,097,233 (+)NCBIHuRef
CHM1_11631,801,165 - 31,851,694 (+)NCBICHM1_1
T2T-CHM13v2.01630,859,706 - 30,910,154 (+)NCBIT2T-CHM13v2.0
Itgal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,895,404 - 126,934,309 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,895,432 - 126,934,310 (+)EnsemblGRCm39 Ensembl
GRCm387127,296,139 - 127,335,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,296,260 - 127,335,138 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,439,862 - 134,477,412 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,087,558 - 127,124,876 (+)NCBIMGSCv36mm8
Celera7127,147,867 - 127,186,306 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.44NCBI
Itgal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,397,991 - 7,439,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554937,397,813 - 7,435,420 (+)NCBIChiLan1.0ChiLan1.0
ITGAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21833,678,868 - 33,730,071 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,480,286 - 38,531,140 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,445,966 - 24,496,037 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11630,843,567 - 30,894,120 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,843,747 - 30,892,597 (+)Ensemblpanpan1.1panPan2
ITGAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,605,611 - 17,645,134 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,605,760 - 17,644,986 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,178,232 - 19,219,073 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,735,141 - 17,775,970 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,733,504 - 17,775,843 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,535,332 - 17,576,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,450,788 - 17,491,710 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,765,852 - 17,806,699 (-)NCBIUU_Cfam_GSD_1.0
Itgal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,823,517 - 124,869,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,922,642 - 12,966,663 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,921,509 - 12,966,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,817,011 - 17,858,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,817,785 - 17,858,057 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,259,483 - 18,299,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,157,866 - 27,206,802 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,157,878 - 27,206,714 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,301,391 - 2,352,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,640,996 - 13,669,541 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,635,217 - 13,671,401 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgal
364 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:400
Count of miRNA genes:203
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000024404
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
RH127875  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024404   ⟹   ENSRNOP00000024404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,918,183 - 181,955,732 (+)Ensembl
Rnor_6.0 Ensembl1198,744,050 - 198,781,750 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104248   ⟹   ENSRNOP00000081712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,919,023 - 181,955,732 (+)Ensembl
RefSeq Acc Id: NM_001033998   ⟹   NP_001029170
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,348,675 - 191,386,228 (+)NCBI
mRatBN7.21181,918,183 - 181,955,735 (+)NCBI
Rnor_6.01198,744,192 - 198,781,745 (+)NCBI
Rnor_5.01205,742,280 - 205,780,282 (+)NCBI
RGSC_v3.41186,561,795 - 186,598,908 (+)RGD
Celera1179,569,739 - 179,607,287 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230269   ⟹   XP_006230331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,348,424 - 191,386,218 (+)NCBI
mRatBN7.21181,918,260 - 181,955,361 (+)NCBI
Rnor_6.01198,744,053 - 198,781,737 (+)NCBI
Rnor_5.01205,742,280 - 205,780,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078348   ⟹   XP_038934276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,348,853 - 191,386,218 (+)NCBI
mRatBN7.21181,918,365 - 181,955,361 (+)NCBI
RefSeq Acc Id: NP_001029170   ⟸   NM_001033998
- Peptide Label: precursor
- UniProtKB: Q3T1L6 (UniProtKB/TrEMBL),   A0A8I5ZT41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230331   ⟸   XM_006230269
- Peptide Label: isoform X1
- UniProtKB: F1LP44 (UniProtKB/TrEMBL),   A0A8I5ZT41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024404   ⟸   ENSRNOT00000024404
RefSeq Acc Id: XP_038934276   ⟸   XM_039078348
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZT41 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081712   ⟸   ENSRNOT00000104248
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LP44-F1-model_v2 AlphaFold F1LP44 1-1161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690431
Promoter ID:EPDNEW_R955
Type:initiation region
Name:Itgal_1
Description:integrin subunit alpha L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,744,177 - 198,744,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631424 AgrOrtholog
BioCyc Gene G2FUF-57374 BioCyc
Ensembl Genes ENSRNOG00000017980 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024404.7 UniProtKB/TrEMBL
  ENSRNOT00000104248.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.2120 UniProtKB/TrEMBL
  2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7938065 IMAGE-MGC_LOAD
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:308995 UniProtKB/TrEMBL
MGC_CLONE MGC:124736 IMAGE-MGC_LOAD
NCBI Gene 308995 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-L UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PharmGKB ITGAL RGD
PhenoGen Itgal PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017980 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8I5ZT41 ENTREZGENE, UniProtKB/TrEMBL
  A6I9N9_RAT UniProtKB/TrEMBL
  F1LP44 ENTREZGENE, UniProtKB/TrEMBL
  Q3T1L6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgal  integrin subunit alpha L  Itgal  integrin, alpha L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgal  integrin, alpha L  Itgal  integrin alpha L  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Itgal  integrin alpha L      Symbol and Name status set to approved 625702 APPROVED