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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itgal
Name: integrin subunit alpha L
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgalaffects bindingISOITGAL (Homo sapiens)6480464CTDSimvastatin binds to [ITGAL protein binds to ITGB2 protein]PMID:15041742
Itgaldecreases expressionISOITGAL (Homo sapiens)6480464CTDSimvastatin results in decreased expression of ITGAL mRNAPMID:12615677
Itgalmultiple interactionsISOITGAL (Homo sapiens)6480464CTDSimvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the activity of CHAT protein]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHAT mRNA]; Simvastatin inhibits the reaction [ITGAL affects the susceptibility to and affects the expression of CHRM5 mRNA]; Simvastatin inhibits the reaction [TNF results in increased expression of ITGAL]PMID:12615677 PMID:16828882
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