Icam1 (intercellular adhesion molecule 1) - Rat Genome Database

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Gene: Icam1 (intercellular adhesion molecule 1) Rattus norvegicus
Symbol: Icam1
Name: intercellular adhesion molecule 1
RGD ID: 2857
Description: Enables integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; eicosanoid signaling pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; (+)-Tetrandrine; (S)-colchicine.
Type: protein-coding
Previously known as: CD54; ICAM; ICAM-1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2819,553,063 - 19,565,438 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)Ensembl
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
Celera820,948,090 - 20,959,852 (+)NCBICelera
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP,IMP)
acute kidney failure  (IEP)
Acute Lung Injury  (IEP,ISO)
acute necrotizing pancreatitis  (IEP)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Animal Hepatitis  (ISO)
arteriosclerosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Brain Death  (IEP)
brain edema  (IEP)
brain infarction  (ISO)
Brain Injuries  (IEP)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchus carcinoma  (ISO)
bullous pemphigoid  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (IEP)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (IEP)
Chronic Bronchitis  (IEP)
chronic obstructive pulmonary disease  (ISO)
chronic ulcer of skin  (ISO)
colitis  (IEP)
Colonic Neoplasms  (ISO)
contact dermatitis  (ISO)
Crohn's disease  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (IDA,ISO)
Diabetic Nephropathies  (IDA,ISO)
diabetic retinopathy  (IEP,ISO)
Diaphragmatic Hernia  (ISO)
diffuse large B-cell lymphoma  (ISO)
end stage renal disease  (IEP)
Endotoxemia  (IEP)
Enteritis  (IEP)
Eosinophilic Myocarditis  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (IMP)
Experimental Colitis  (IMP)
Experimental Diabetes Mellitus  (IEP,ISO)
Fibrosis  (IEP)
gestational diabetes  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss, Noise-Induced  (IMP)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (IEP)
hyperhomocysteinemia  (IEP)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (IEP)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (IDA,IEP,ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (IEP)
Intimal Hyperplasia  (IMP)
iridocyclitis  (ISO)
Jaundice  (IEP)
Kidney Neoplasms  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (IEP)
Liver Reperfusion Injury  (IEP,IMP)
localized scleroderma  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (ISO)
Lymphocytic Myocarditis  (ISO)
malaria  (ISO)
melanoma  (ISO)
Mercury Poisoning  (IEP)
mesenteric vascular occlusion  (IMP)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (IEP,ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (IMP)
nephrosis  (ISO)
newborn respiratory distress syndrome  (IEP,ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (IEP,ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
pneumonia  (IEP)
pre-eclampsia  (IMP)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (IMP)
Prinzmetal angina  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (IEP)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (IEP)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (IEP,IMP)
retinal disease  (ISO)
retinopathy of prematurity  (IEP)
rheumatic fever  (ISO)
rheumatic myocarditis  (ISO)
sciatic neuropathy  (IEP)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (IMP)
Stroke  (IMP,ISO)
Subarachnoid Hemorrhage  (IEP)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (IDA,ISO)
venous insufficiency  (ISO)
Viral Myocarditis  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-linalyl acetate  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,10-phenanthroline  (ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,8-cineole  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitroiodobenzene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
acteoside  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allicin  (ISO)
alloxan  (ISO)
alpha-naphthoflavone  (EXP)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
AM-251  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
argatroban  (ISO)
aripiprazole  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
aspalathin  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atropine  (ISO)
Bandrowski's base  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-eudesmol  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bongkrekic acid  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
candesartan  (EXP)
Candesartan cilexetil  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
capsazepine  (ISO)
capsiate  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
Carboxyatractyloside  (ISO)
carnosine  (ISO)
Carnosol  (ISO)
carrageenan  (EXP,ISO)
CDP-choline  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
ceruletide  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloroquine  (ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
citral  (ISO)
citric acid  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
cloricromen  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
daunorubicin  (EXP)
Decursin  (ISO)
deguelin  (ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desflurane  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
Dimaprit  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
donepezil hydrochloride  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
emodin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
ergosterol  (EXP)
erythromycin A  (ISO)
estrone  (EXP)
ethanol  (ISO)
Ethyl icosapentate  (ISO)
etoricoxib  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
famotidine  (ISO)
farnesol  (ISO)
farnesyl diphosphate  (ISO)
fasudil  (EXP)
fenamidone  (ISO)
fenbuconazole  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferrous oxide  (ISO)
Fexofenadine hydrochloride  (ISO)
filipin III  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
flurbiprofen  (EXP)
fluticasone  (ISO)
fluvoxamine  (EXP,ISO)
formaldehyde  (EXP,ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumaric acid  (ISO)
gadolinium trichloride  (ISO)
galangin  (ISO)
gallic acid  (EXP)
Garcinol  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside C-K  (ISO)
glafenine  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
graphite  (EXP)
GW 3965  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 6471  (ISO)
halothane  (EXP,ISO)
helenalin  (ISO)
herbimycin  (ISO)
hesperetin  (EXP)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrazines  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (EXP)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (ISO)
hyperforin  (ISO)
ibuprofen  (ISO)
icatibant  (EXP)
imidurea  (ISO)
imiquimod  (ISO)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
Isoangustone A  (ISO)
isocarbophos  (EXP)
isoflurane  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
jaspamide  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (ISO)
ketorolac  (EXP)
ketotifen  (ISO)
Kukoamine B  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
leukotriene D4  (ISO)
levofloxacin  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lopinavir  (ISO)
losartan  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (ISO)
melittin  (ISO)
melphalan  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (EXP)
Methanandamide  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methylarsonic acid  (ISO)
methylene blue  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methylthiouracil  (ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP)
miquelianin  (ISO)
Mizolastine  (ISO)
monocrotaline  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
myricitrin  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP)
Nandrolone decanoate  (EXP)
naringin  (ISO)
nebivolol  (ISO)
nefazodone  (EXP)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP)
nicotinic acid  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
nystatin  (ISO)
o-anisidine  (ISO)
ochratoxin A  (ISO)
octanoic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oleuropein  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
pelargonidin  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramidon  (EXP)
phthalic anhydride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
PR-39  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrene  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
Quinupristin-dalfopristin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rimonabant  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
sarpogrelate  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP,ISO)
stattic  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP,ISO)
sulfates  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
tacrolimus hydrate  (EXP,ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (EXP,ISO)
telmisartan  (EXP,ISO)
tepoxalin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
tibolone  (ISO)
titanium atom  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trierixin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
xi-3-(4-Isopropylphenyl)-2-methylpropanal  (ISO)
Y-27632  (EXP,ISO)
zerumbone  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (IMP)
adhesion of symbiont to host  (ISO)
cell adhesion  (IBA,ISO)
cell adhesion mediated by integrin  (ISO)
cell-cell adhesion  (IDA,IMP)
cellular response to alkaloid  (IEP)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to glucose stimulus  (IEP,ISO)
cellular response to hypoxia  (IEP)
cellular response to interferon-gamma  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IEP)
cellular response to nutrient levels  (IEP)
cellular response to organic substance  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular senescence  (IEP)
establishment of endothelial barrier  (ISO)
establishment of endothelial intestinal barrier  (IMP)
establishment of Sertoli cell barrier  (IDA)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO,TAS)
membrane to membrane docking  (ISO)
negative regulation of calcium ion transport  (IDA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
ovarian follicle development  (IEP)
positive regulation of actin filament polymerization  (IDA)
positive regulation of cellular extravasation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of GTPase activity  (IDA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of vasoconstriction  (IMP)
receptor-mediated virion attachment to host cell  (ISO)
regulation of activated T cell proliferation  (ISO)
regulation of cell shape  (IMP)
regulation of ruffle assembly  (ISO)
response to amino acid  (IEP)
response to amphetamine  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to gonadotropin  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to ionizing radiation  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to sulfur dioxide  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (IMP)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
T cell antigen processing and presentation  (ISO)
T cell extravasation  (ISO)

Cellular Component

Molecular Function


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Additional References at PubMed
PMID:1448173   PMID:2477710   PMID:2479693   PMID:2538243   PMID:8562500   PMID:9290466   PMID:10528208   PMID:10601245   PMID:10903502   PMID:11078691   PMID:11880280   PMID:12061795  
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Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2819,553,063 - 19,565,438 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)Ensembl
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
Celera820,948,090 - 20,959,852 (+)NCBICelera
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,271,120 - 10,286,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,271,093 - 10,286,615 (+)EnsemblGRCh38hg38GRCh38
GRCh371910,381,796 - 10,397,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,242,779 - 10,258,291 (+)NCBINCBI36hg18NCBI36
Build 341910,242,778 - 10,258,291NCBI
Celera1910,276,917 - 10,292,687 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,965,426 - 9,977,270 (+)NCBIHuRef
CHM1_11910,381,783 - 10,397,556 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39920,927,236 - 20,940,110 (+)NCBIGRCm39mm39
GRCm39 Ensembl920,927,281 - 20,940,113 (+)Ensembl
GRCm38921,015,940 - 21,028,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,015,985 - 21,028,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,820,404 - 20,833,241 (+)NCBIGRCm37mm9NCBIm37
MGSCv36920,766,362 - 20,779,199 (+)NCBImm8
Celera918,284,644 - 18,297,383 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.69NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11910,484,414 - 10,500,605 (+)NCBIpanpan1.1