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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDtelmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]

PMID:20888384
multiple interactionsISORGD:107566480464CTDtelmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]

PMID:17724226
multiple interactionsISORGD:696596480464CTDtelmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:22124178
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.