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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:696596480464CTDbicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]], bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]], Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA], Dihydrotestosterone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:16317058
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.