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Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease.

Authors: Kretowski, A  Wawrusiewicz, N  Mironczuk, K  Mysliwiec, J  Kretowska, M  Kinalska, I 
Citation: Kretowski A, etal., J Clin Endocrinol Metab. 2003 Oct;88(10):4945-9.
Pubmed: (View Article at PubMed) PMID:14557478
DOI: Full-text: DOI:10.1210/jc.2003-030131

It was recently suggested that genetic factors could play a major role in the development of Graves' disease (GD). The aim of the present study was to evaluate the frequency of the c.721G-->A polymorphism and the c.1405A-->G polymorphism of the intercellular adhesion molecule 1 (ICAM-1) gene in subjects with GD compared with that in healthy controls, because ICAM-1 was found to play a key role in lymphocyte infiltration into the thyroid gland and the concentration of the soluble form of ICAM-1 correlates significantly with the clinical activity and treatment status in GD. We have analyzed the association of ICAM-1 polymorphisms with the age at onset of GD and the presence of ophthalmopathy. In a group of 235 patients with GD and 211 healthy controls we have shown that polymorphism at position c.721G-->A is associated with an earlier age of GD onset and that the c.1405A-->G polymorphism of the ICAM-1 gene could predispose to Graves' ophthalmopathy. This suggests that G241R and K469E amino acid substitutions in the ICAM-1 molecule could influence the intensity/duration of the autoimmunity process and the infiltration of orbital tissues. It could be speculated that therapy that modulates ICAM-1 function may delay the onset and/or prolong the remission and/or have an influence on clinical manifestations of GD.


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RGD Object Information
RGD ID: 8158124
Created: 2014-02-11
Species: All species
Last Modified: 2014-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.