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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:35807
Term: N-nitrosodimethylamine
Definition: A nitrosamine that has formula C2H6N2O.
Chemical ID: MESH:D004128
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDimethylnitrosamine results in increased expression of ICAM1 mRNA, Dimethylnitrosamine results in increased expression of ICAM1 protein

PMID:17201889, PMID:17719030, PMID:17724770
multiple interactionsEXP 6480464CTDPlant Preparations inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA], Silymarin inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA], tetrandrine inhibits the reaction [Dimethylnitrosamine results in increased expression of ICAM1 mRNA]

PMID:17201889, PMID:17724770
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.