ICAM1 (intercellular adhesion molecule 1) - Rat Genome Database

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Gene: ICAM1 (intercellular adhesion molecule 1) Homo sapiens
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Symbol: ICAM1
Name: intercellular adhesion molecule 1
RGD ID: 69659
HGNC Page HGNC:5344
Description: Enables integrin binding activity. Involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; cellular response to amyloid-beta; and regulation of apoptotic process. Located in extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and multiple myeloma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BB2; CD54; cell surface glycoprotein P3.58; human rhinovirus receptor; ICAM-1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor; P3.58
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,271,120 - 10,286,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,271,093 - 10,286,615 (+)EnsemblGRCh38hg38GRCh38
GRCh371910,381,796 - 10,397,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,242,779 - 10,258,291 (+)NCBINCBI36Build 36hg18NCBI36
Build 341910,242,778 - 10,258,291NCBI
Celera1910,276,917 - 10,292,687 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,965,426 - 9,977,270 (+)NCBIHuRef
CHM1_11910,381,783 - 10,397,556 (+)NCBICHM1_1
T2T-CHM13v2.01910,397,229 - 10,412,727 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (EXP,ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (IEP)
alcoholic hepatitis  (IEP)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (IEP)
allergic disease  (IEP)
Alzheimer's disease  (IAGP)
Animal Hepatitis  (ISO)
arteriosclerosis  (EXP)
asthma  (EXP,IEP,ISO)
atherosclerosis  (EXP)
B-Cell Chronic Lymphocytic Leukemia  (IEP)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (EXP,IAGP)
biliary atresia  (IAGP)
Brain Death  (ISO)
brain edema  (ISO)
brain infarction  (IEP)
Brain Injuries  (ISO)
brain ischemia  (EXP)
breast cancer  (IEP)
Bronchial Hyperreactivity  (EXP)
bronchiectasis  (EXP)
bronchus carcinoma  (IEP)
bullous pemphigoid  (IEP)
cardiovascular system disease  (EXP)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholestasis  (EXP)
cholesteatoma of middle ear  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (EXP,IEP,ISO)
chronic ulcer of skin  (IEP)
colitis  (ISO)
Colonic Neoplasms  (EXP)
contact dermatitis  (ISO)
Crohn's disease  (IAGP)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diabetes mellitus  (IEP)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IAGP,IEP,ISO)
diabetic retinopathy  (EXP,IAGP,IEP,ISO)
Diaphragmatic Hernia  (EXP)
diffuse large B-cell lymphoma  (IEP)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Enteritis  (ISO)
Eosinophilic Myocarditis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Fibrosis  (ISO)
gestational diabetes  (IEP)
Graft vs Host Disease  (ISO)
Graves ophthalmopathy  (IAGP)
Graves' disease  (IAGP,IEP)
Hashimoto Disease  (IEP)
Hearing Loss, Noise-Induced  (ISO)
Hemorrhagic Shock  (EXP,ISO)
hepatocellular carcinoma  (IEP)
Hodgkin's lymphoma  (EXP,IEP)
Hypercholesterolemia  (EXP)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (EXP,IEP)
hypertrophic cardiomyopathy  (ISO)
idiopathic interstitial pneumonia  (IEP)
Inflammation  (EXP,ISO)
inflammatory bowel disease  (EXP,IAGP)
Insulin Resistance  (IEP)
Intestinal Reperfusion Injury  (ISO)
Intimal Hyperplasia  (ISO)
iridocyclitis  (IAGP)
Jaundice  (ISO)
Kidney Neoplasms  (IEP)
leukostasis  (EXP)
liver cirrhosis  (IAGP)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (IEP)
Lung Injury  (ISO)
lung non-small cell carcinoma  (IEP)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (IEP)
Lymphocytic Myocarditis  (IEP)
malaria  (EXP,IAGP)
melanoma  (IEP)
Mercury Poisoning  (ISO)
mesenteric vascular occlusion  (ISO)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (EXP)
Mouth Neoplasms  (EXP)
multiple myeloma  (IEP,IMP)
Multiple Organ Failure  (ISO)
multiple sclerosis  (EXP)
myocardial infarction  (EXP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
myocarditis  (IEP,ISO)
Nasal Polyps  (IEP)
Neoplasm Metastasis  (IEP)
neovascular inflammatory vitreoretinopathy  (IEP)
nephritis  (ISO)
nephrosis  (EXP)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (IEP)
obesity  (EXP,IEP,ISO)
obstructive sleep apnea  (IEP)
otitis media  (IEP)
ovarian cancer  (IEP)
pancreatic cancer  (IEP)
pancreatitis  (IEP,ISO)
paracoccidioidomycosis  (ISO)
Penetrating Wounds  (ISO)
Perennial Allergic Rhinitis  (IEP,ISO)
peripheral nervous system disease  (EXP)
pleurisy  (EXP,IEP,ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prinzmetal angina  (IEP)
prostate cancer  (IDA)
Prostatic Neoplasms  (EXP)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (IEP,IMP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP)
Reperfusion Injury  (EXP)
respiratory syncytial virus infectious disease  (EXP,IEP)
Retina Reperfusion Injury  (ISO)
retinal disease  (EXP)
retinopathy of prematurity  (ISO)
rheumatic fever  (IEP)
rheumatic myocarditis  (IEP)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (IEP)
Sepsis  (ISO)
Sjogren's syndrome  (IEP,ISO)
skin melanoma  (IAGP)
Spinal Cord Injuries  (ISO)
Stroke  (EXP,ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (IEP)
transient cerebral ischemia  (ISO)
Traumatic Brain Injuries  (EXP)
type 1 diabetes mellitus  (IAGP,IEP)
type 2 diabetes mellitus  (EXP,IEP,ISO)
ulcerative colitis  (EXP,ISO)
uremia  (EXP)
ureteral obstruction  (ISO)
urinary bladder cancer  (IEP)
urticaria  (EXP)
uveitis  (IEP,ISO)
venous insufficiency  (IEP)
Viral Myocarditis  (ISO)
Wounds and Injuries  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (EXP)
(-)-demecolcine  (EXP)
(20S)-ginsenoside Rh1  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-linalyl acetate  (ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (EXP)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,10-phenanthroline  (EXP)
1,8-cineole  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitroiodobenzene  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
22-Hydroxycholesterol  (EXP)
26-hydroxycholesterol  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (EXP)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9-phenanthrol  (EXP)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
albendazole  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allicin  (EXP)
alloxan  (EXP)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (EXP)
aluminium oxide  (EXP)
AM-251  (EXP)
amiodarone  (EXP)
amlodipine  (ISO)
ammonium acetate  (ISO)
ammonium chloride  (ISO)
anagliptin  (EXP)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
apigenin  (EXP)
apocynin  (EXP,ISO)
argatroban  (ISO)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
aspalathin  (EXP)
astemizole  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP)
atropine  (ISO)
Bandrowski's base  (EXP)
Bardoxolone methyl  (EXP)
beclomethasone  (EXP)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beryllium sulfate  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-eudesmol  (ISO)
bezafibrate  (EXP)
bicalutamide  (EXP)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bongkrekic acid  (EXP)
bortezomib  (EXP)
bromobenzene  (EXP)
bucladesine  (EXP)
buspirone  (ISO)
butanal  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (EXP,ISO)
calcitriol  (EXP)
calcium dichloride  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
capsazepine  (EXP)
capsiate  (EXP)
carbamazepine  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
Carboxyatractyloside  (EXP)
carnosine  (ISO)
Carnosol  (EXP)
carrageenan  (ISO)
CDP-choline  (ISO)
cefaloridine  (ISO)
celastrol  (EXP)
celecoxib  (EXP)
cerivastatin  (EXP)
ceruletide  (EXP,ISO)
chenodeoxycholic acid  (EXP,ISO)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (EXP)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(3+) trichloride  (EXP)
chromium(6+)  (EXP)
chrysene  (EXP)
chrysin  (EXP)
ciglitazone  (EXP)
cimetidine  (EXP)
cisplatin  (EXP,ISO)
citral  (EXP)
citric acid  (EXP)
clobetasol  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
cloricromen  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
conjugated linoleic acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cortisol  (EXP,ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cytochalasin D  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
dabrafenib  (EXP)
daunorubicin  (ISO)
Decursin  (ISO)
deguelin  (EXP)
delta-tocotrienol  (ISO)
deoxycholic acid  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
desflurane  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (EXP)
dicrotophos  (EXP)
Didecyldimethylammonium  (EXP)
diethyl maleate  (EXP,ISO)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
Dimaprit  (EXP)
dimethyl fumarate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
dipyridamole  (ISO)
disodium selenite  (EXP)
donepezil hydrochloride  (EXP)
doramapimod  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
emodin  (ISO)
enalapril  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
ergosterol  (ISO)
erythromycin A  (EXP)
estrone  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
Ethyl icosapentate  (ISO)
etoricoxib  (EXP)
eugenol  (EXP)
Evodiamine  (EXP)
famotidine  (EXP)
farnesol  (EXP)
farnesyl diphosphate  (EXP)
fasudil  (ISO)
fenamidone  (ISO)
fenbuconazole  (EXP)
fenofibrate  (EXP,ISO)
ferric oxide  (EXP)
ferrous oxide  (EXP)
Fexofenadine hydrochloride  (EXP)
filipin III  (EXP)
flavonoids  (EXP)
fluoranthene  (EXP)
flurbiprofen  (ISO)
fluticasone  (EXP)
fluvoxamine  (EXP,ISO)
formaldehyde  (EXP,ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumaric acid  (ISO)
gadolinium trichloride  (ISO)
galangin  (EXP)
galanthamine  (ISO)
gallic acid  (ISO)
Garcinol  (EXP)
gemcitabine  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (EXP)
geraniol  (EXP,ISO)
ginsenoside C-K  (EXP)
glafenine  (ISO)
gliclazide  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
graphite  (ISO)
GW 3965  (EXP)
GW 4064  (EXP)
GW 501516  (EXP)
GW 6471  (EXP)
halothane  (ISO)
helenalin  (EXP,ISO)
herbimycin  (EXP)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
hexamethylene diisocyanate  (EXP)
histamine  (EXP)
Honokiol  (ISO)
hydralazine  (EXP)
hydrazines  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP)
hydroxamic acid  (ISO)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (EXP)
hyperforin  (EXP)
ibuprofen  (EXP)
icatibant  (ISO)
imidurea  (EXP)
imiquimod  (ISO)
immunological adjuvant  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
Isoangustone A  (EXP)
isocarbophos  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
jaspamide  (EXP)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (EXP)
ketamine  (ISO)
ketorolac  (ISO)
ketotifen  (EXP)
Kukoamine B  (ISO)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leukotriene D4  (EXP)
levofloxacin  (EXP,ISO)
linalool  (EXP,ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
lithium chloride  (EXP)
lithocholic acid  (EXP,ISO)
lopinavir  (EXP)
losartan  (EXP)
lucanthone  (EXP)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (EXP)
lysophosphatidylcholine  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
medroxyprogesterone acetate  (EXP)
melittin  (EXP)
melphalan  (EXP)
mercury dichloride  (ISO)
metformin  (ISO)
Methanandamide  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (EXP,ISO)
methyl beta-cyclodextrin  (EXP)
methylarsonic acid  (ISO)
methylene blue  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
Methylthiouracil  (EXP)
mifepristone  (EXP,ISO)
minocycline  (ISO)
miquelianin  (EXP)
Mizolastine  (EXP)
monocrotaline  (ISO)
morphine  (ISO)
Morroniside  (ISO)
Muraglitazar  (ISO)
myricitrin  (ISO)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (ISO)
Nandrolone decanoate  (ISO)
naringin  (EXP,ISO)
nebivolol  (EXP)
nefazodone  (ISO)
neocuproine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofen  (ISO)
nitrogen dioxide  (EXP)
notoginsenoside R1  (ISO)
NS-398  (ISO)
NSC 23766  (EXP)
nystatin  (ISO)
o-anisidine  (EXP)
ochratoxin A  (ISO)
octanoic acid  (EXP)
olaparib  (ISO)
oleanolic acid  (EXP)
oleuropein  (EXP)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
p-cresol  (EXP)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (EXP)
pelargonidin  (EXP)
pentanal  (EXP)
pentobarbital  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perindopril  (ISO)
phenanthrene  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphoramidon  (ISO)
phthalic anhydride  (EXP)
pimecrolimus  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
polymyxin B2  (EXP)
polyphosphates  (EXP)
potassium chloride  (EXP)
potassium dichromate  (EXP)
PR-39  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
prostaglandin E2  (ISO)
puerarin  (EXP)
pyrene  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
Quinupristin-dalfopristin  (EXP)
rac-lactic acid  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
rimonabant  (EXP,ISO)
ritonavir  (EXP)
romidepsin  (EXP)
rotenone  (EXP,ISO)
Ruscogenin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP)
sarpogrelate  (EXP)
saxagliptin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP)
Sodium salicylate  (EXP)
sodium stibogluconate  (ISO)
Soman  (ISO)
stattic  (EXP)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulfasalazine  (EXP,ISO)
sulfates  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sulindac  (EXP)
tacrolimus hydrate  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
tepoxalin  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
Tetramethylthiourea  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thalidomide  (EXP,ISO)
thioacetamide  (ISO)
thiram  (EXP)
tibolone  (EXP)
titanium atom  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trierixin  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (ISO)
trovafloxacin  (EXP,ISO)
ursolic acid  (EXP)
valproic acid  (EXP)
valsartan  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (EXP)
vorinostat  (EXP)
wortmannin  (EXP,ISO)
xanthohumol  (EXP)
xi-3-(4-Isopropylphenyl)-2-methylpropanal  (EXP)
Y-27632  (EXP,ISO)
zerumbone  (EXP)
zileuton  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
adhesion of symbiont to host  (IDA)
cell adhesion  (IBA,IDA,IEA,ISO)
cell adhesion mediated by integrin  (IEA,ISO)
cell-cell adhesion  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to amyloid-beta  (IDA)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular senescence  (ISO)
establishment of endothelial barrier  (IGI)
establishment of endothelial intestinal barrier  (ISO)
establishment of Sertoli cell barrier  (ISO)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (TAS)
leukocyte cell-cell adhesion  (IMP,ISO)
leukocyte migration  (IEP)
membrane to membrane docking  (IEP)
negative regulation of calcium ion transport  (ISO)
negative regulation of endothelial cell apoptotic process  (IDA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IDA)
ovarian follicle development  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cellular extravasation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of GTPase activity  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of T cell apoptotic process  (IMP)
positive regulation of vasoconstriction  (ISO)
receptor-mediated virion attachment to host cell  (IDA)
regulation of activated T cell proliferation  (IMP)
regulation of cell shape  (ISO)
regulation of leukocyte mediated cytotoxicity  (TAS)
regulation of ruffle assembly  (IEA,ISO)
response to amino acid  (ISO)
response to amphetamine  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to gonadotropin  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to ionizing radiation  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to sulfur dioxide  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (IMP)
T cell antigen processing and presentation  (IEA,ISO)
T cell extravasation  (IEA,ISO)
viral entry into host cell  (IEA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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84. Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis. Manetti M, etal., Arthritis Rheum. 2008 Sep;58(9):2866-73. doi: 10.1002/art.23806.
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87. Expression on leukemic cells and serum circulating levels of intercellular adhesion molecule-1 (ICAM-1) in B-cell chronic lymphocytic leukemia: implications for prognosis. Molica S, etal., Leuk Res. 1995 Aug;19(8):573-80.
88. Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis. Moreira AP, etal., Am J Pathol. 2006 Oct;169(4):1270-81.
89. Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain. Mousa SA, etal., Brain Behav Immun. 2010 Nov;24(8):1310-23. Epub 2010 Jul 1.
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