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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:4696
Term: donepezil hydrochloride
Definition: A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Chemical ID: MESH:C076946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Icam1affects expressionISOICAM1 (Homo sapiens)6480464CTDDonepezil affects the expression of ICAM1 mRNA; Donepezil affects the expression of ICAM1 proteinPMID:32174113
Icam1multiple interactionsISOICAM1 (Homo sapiens)6480464CTDEGR1 protein affects the reaction [Donepezil affects the expression of ICAM1 protein]PMID:32174113
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