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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species:
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTretinoin results in decreased expression of ICAM1 mRNA

PMID:12969142, PMID:20488242
multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [nitrofen results in decreased expression of ICAM1 mRNA], Tretinoin inhibits the reaction [nitrofen results in decreased expression of ICAM1 protein]

PMID:18280292
increases expressionISORGD:696596480464CTDTretinoin results in increased expression of ICAM1 mRNA, Tretinoin results in increased expression of ICAM1 protein

PMID:15894607, PMID:18055984, PMID:23830798, PMID:23864846, PMID:24953245
multiple interactionsISORGD:107566480464CTD[bisphenol F co-treated with Tretinoin] results in decreased expression of ICAM1 mRNA

PMID:30951980
multiple interactionsISORGD:696596480464CTD[Tretinoin co-treated with arsenic trioxide] results in increased expression of ICAM1 mRNA, AG 1879 promotes the reaction [arsenic trioxide promotes the reaction [Tretinoin results in increased expression of ICAM1 protein]], arsenic trioxide promotes the reaction [Tretinoin results in increased expression of ICAM1 protein], Dexamethasone inhibits the reaction [Tretinoin results in increased expression of ICAM1 protein], ICAM1 protein promotes the reaction [Tretinoin results in increased expression of ITGAM protein], Tretinoin promotes the reaction [AG 1879 results in increased expression of ICAM1 protein]

PMID:15894607, PMID:18055984, PMID:23864846, PMID:24953245
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.