Vcam1 (vascular cell adhesion molecule 1) - Rat Genome Database

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Gene: Vcam1 (vascular cell adhesion molecule 1) Rattus norvegicus
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Symbol: Vcam1
Name: vascular cell adhesion molecule 1
RGD ID: 3952
Description: Enables integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Human ortholog(s) of this gene implicated in gastrointestinal system disease. Orthologous to human VCAM1 (vascular cell adhesion molecule 1); PARTICIPATES IN eicosanoid signaling pathway; malaria pathway; sleeping sickness pathway; INTERACTS WITH (S)-colchicine; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100912479; MGC108734; V-CAM 1; vascular cell adhesion protein 1; vascular cell adhesion protein 1-like; VCAM-1; VCAM1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Candidate Gene For: Cia10
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22204,038,120 - 204,057,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,038,114 - 204,057,958 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2211,702,572 - 211,722,182 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02209,587,221 - 209,606,807 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02204,404,257 - 204,423,843 (-)NCBIRnor_WKY
Rnor_6.02219,071,193 - 219,090,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,071,193 - 219,097,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,158,192 - 237,177,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,277,654 - 212,297,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,240,407 - 212,260,130 (-)NCBI
Celera2196,537,457 - 196,557,044 (-)NCBICelera
RH 3.4 Map21480.6RGD
Cytogenetic Map2q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Albuminuria  (ISO)
Anaphylaxis  (IMP)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic disease  (IEP)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (IMP)
cholestasis  (ISO)
chronic kidney disease  (IEP,ISO)
colitis  (IEP)
dermatitis  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
Endotoxemia  (IEP)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (IEP,ISO)
familial hyperlipidemia  (IEP)
gastrointestinal system disease  (ISO)
glomerulonephritis  (ISO)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (IAGP,IEP,ISO)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
intrahepatic cholestasis of pregnancy  (ISO)
Kidney Reperfusion Injury  (IEP)
Left Ventricular Hypertrophy  (ISO)
lupus nephritis  (ISO)
Lymphocytic Myocarditis  (ISO)
Metabolic Syndrome  (IEP)
multiple sclerosis  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
periodontitis  (IEP)
Pregnancy in Diabetics  (ISO)
Primary Graft Dysfunction  (ISO)
pulmonary embolism  (IEP)
pulmonary hypertension  (IEP)
Reperfusion Injury  (IEP)
rheumatic myocarditis  (ISO)
sickle cell anemia  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
thromboangiitis obliterans  (IEP,ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
urticaria  (ISO)
Venous Thrombosis  (IEP)
Vitamin A Deficiency  (IEP)
Vitamin D Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-linalyl acetate  (ISO)
(R)-mevalonic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2-acetamidofluorene  (EXP,ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7-ketocholesterol  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-phenanthrol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-linolenic acid  (EXP)
aluminium oxide  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
astemizole  (ISO)
atorvastatin calcium  (EXP,ISO)
atropine  (ISO)
bacitracin  (EXP)
Bardoxolone methyl  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
biochanin A  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
budesonide  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calmidazolium  (ISO)
candesartan  (EXP)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carrageenan  (EXP)
cefaloridine  (EXP)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
cortisol  (ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
dantrolene  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP,ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (ISO)
desferrioxamine B  (EXP,ISO)
desflurane  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
edaravone  (EXP)
enalapril  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
esculetin  (EXP)
estriol  (ISO)
estrone  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
filipin III  (ISO)
fluoranthene  (ISO)
fluticasone  (ISO)
fluvoxamine  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
Fraxinellone  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumaric acid  (ISO)
furan  (EXP)
furosemide  (EXP)
gallic acid  (EXP)
Garcinol  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
ginkgolide B  (ISO)
ginsenoside C-K  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
Goe 6976  (ISO)
griseofulvin  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 501516  (ISO)
halothane  (ISO)
helenalin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (EXP)
hydroxysafflor yellow A  (EXP,ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (ISO)
irbesartan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isocarbophos  (EXP)
isoprenaline  (ISO)
jaspamide  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
ketamine  (ISO)
ketotifen  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levofloxacin  (EXP)
levonorgestrel  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
manidipine  (EXP)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melittin  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
methapyrilene  (EXP)
methcathinone  (ISO)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
Methylthiouracil  (ISO)
mifepristone  (EXP,ISO)
miquelianin  (ISO)
mometasone furoate  (ISO)
monocrotaline  (EXP)
Muraglitazar  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naproxen  (EXP)
naringin  (ISO)
nebivolol  (ISO)
neocuproine  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
notoginsenoside R1  (ISO)
NSC 23766  (ISO)
o-anisidine  (ISO)
oleanolic acid  (ISO)
oleuropein  (ISO)
oroxylin A  (EXP)
oxaliplatin  (EXP)
oxytocin  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parthenolide  (ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
phenacetin  (EXP)
Phenelzine  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
polyphosphates  (ISO)
potassium dichromate  (ISO)
PR-39  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probucol  (ISO)
procyanidin B2  (EXP)
progesterone  (EXP,ISO)
protoporphyrin  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-sulfate  (ISO)
Quinupristin-dalfopristin  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
ricinoleic acid  (ISO)
rimonabant  (ISO)
rutin  (ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarpogrelate  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sinigrin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sphingosine 1-phosphate  (ISO)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (EXP,ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP)
thioacetamide  (EXP,ISO)
thiram  (ISO)
tibolone  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (EXP)
triamcinolone acetonide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
U-73122  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
wedelolactone  (ISO)
XAV939  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proliferative diabetic retinopathy-The influence of diabetes control on the activation of the intraocular molecule system. Adamiec-Mroczek J, etal., Diabetes Res Clin Pract. 2009 Apr;84(1):46-50. Epub 2009 Feb 23.
2. Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria. Agarwal PK, etal., Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F895-904. doi: 10.1152/ajprenal.00507.2011. Epub 2012 Jan 4.
3. Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch-Schonlein purpura. Amoli MM, etal., J Rheumatol. 2001 May;28(5):1014-8.
4. Renal expression of adhesion molecules in anca-associated disease. Arrizabalaga P, etal., J Clin Immunol. 2008 Sep;28(5):411-9. doi: 10.1007/s10875-008-9215-2. Epub 2008 Jun 24.
5. Early atherosclerosis and vascular inflammation in mice with diet-induced type 2 diabetes. Bartels ED, etal., Eur J Clin Invest. 2009 Mar;39(3):190-9.
6. Serum visfatin as a non-traditional biomarker of endothelial dysfunction in chronic kidney disease: an Egyptian study. Bessa SS, etal., Eur J Intern Med. 2010 Dec;21(6):530-5. doi: 10.1016/j.ejim.2010.09.011. Epub 2010 Oct 20.
7. Alteration in the expression of inflammatory parameters as a result of oxidative stress produced by moderate zinc deficiency in rat lung. Biaggio VS, etal., Exp Lung Res. 2010 Feb;36(1):31-44.
8. The levels of adhesion molecules in essential thrombocythemia. Bilgir F, etal., Panminerva Med. 2013 Dec;55(4):385-90.
9. Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients. Boulbou MS, etal., Acta Diabetol. 2004 Sep;41(3):118-22.
10. Plasma ICAM-1 and VCAM-1 levels in type 2 diabetic patients with and without microalbuminuria. Bruno CM, etal., Minerva Med. 2008 Feb;99(1):1-5.
11. Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Burke DL, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L238-50. Epub 2009 May 22.
12. Fas-associated death-domain protein inhibits TNF-alpha mediated NF-kappaB activation in cardiomyocytes. Chao W, etal., Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2073-80. doi: 10.1152/ajpheart.01216.2004. Epub 2005 Jun 24.
13. Vitamin D status is linked to biomarkers of oxidative stress, inflammation, and endothelial activation in obese children. Codoner-Franch P, etal., J Pediatr. 2012 Nov;161(5):848-54. doi: 10.1016/j.jpeds.2012.04.046. Epub 2012 Jun 5.
14. Mapping the cytokine profile of painful bladder syndrome/interstitial cystitis in human bladder and urine specimens. Corcoran AT, etal., World J Urol. 2013 Feb;31(1):241-6. doi: 10.1007/s00345-012-0852-y. Epub 2012 Mar 24.
15. Apelin Retards the Progression of Diabetic Nephropathy. Day RT, etal., Am J Physiol Renal Physiol. 2013 Jan 9.
16. Effects of periodontitis on aortic insulin resistance in an obese rat model. Ekuni D, etal., Lab Invest. 2010 Mar;90(3):348-59. doi: 10.1038/labinvest.2009.141. Epub 2010 Jan 11.
17. Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Gao Z, etal., Exp Ther Med. 2012 Dec;4(6):993-998. Epub 2012 Sep 14.
18. Implication of vitamin A deficiency on vascular injury related to inflammation and oxidative stress. Effects on the ultrastructure of rat aorta. Gatica LV, etal., Eur J Nutr. 2012 Feb;51(1):97-106. doi: 10.1007/s00394-011-0198-z. Epub 2011 Apr 22.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat. Congenic Analysis. Graham D, etal., Hypertension. 2007 Oct 15;.
21. Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia-reperfusion injury. Grieve SM, etal., Eur Biophys J. 2013 Jan;42(1):61-70. doi: 10.1007/s00249-012-0857-x. Epub 2012 Sep 28.
22. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
23. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
24. Prediction of residual valvular lesions in rheumatic heart disease: role of adhesion molecules. Hafez M, etal., Pediatr Cardiol. 2013 Mar;34(3):583-90. doi: 10.1007/s00246-012-0501-7. Epub 2012 Sep 18.
25. Expression of ICAM-1, VCAM-1, E-selectin and TNF-alpha on the endothelium of femoral and iliac arteries in thromboangiitis obliterans. Halacheva K, etal., Acta Histochem. 2002;104(2):177-84.
26. Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. Hao G, etal., PLoS One. 2013;8(2):e57418. doi: 10.1371/journal.pone.0057418. Epub 2013 Feb 27.
27. Cloning of murine and rat vascular cell adhesion molecule-1. Hession C, etal., Biochem Biophys Res Commun 1992 Feb 28;183(1):163-9.
28. Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1 alpha by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats. Hofmann N, etal., BMC Immunol. 2002 Aug 26;3:11.
29. Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. Ibrahim A, etal., Nutrition. 2012 Jul;28(7-8):799-802. doi: 10.1016/j.nut.2011.10.008. Epub 2012 Jan 20.
30. Late persistent expressions of ICAM-1 and VCAM-1 on myocardial tissue in children with lymphocytic myocarditis. Ino T, etal., Cardiovasc Res. 1997 May;34(2):323-8.
31. Adhesion molecule expression in experimental myositis. Ito T, etal., Muscle Nerve. 2002 Mar;25(3):409-18.
32. Alpha 4 integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. Johnston B, etal., J Immunol. 2000 Mar 15;164(6):3337-44.
33. Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Jung KJ, etal., Inflamm Res. 2009 Mar;58(3):143-50.
34. High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease. Kim HJ, etal., Clin Exp Nephrol. 2010 Sep 7.
35. High-mobility-group box protein 1 A box reduces development of sodium laurate-induced thromboangiitis obliterans in rats. Kong X, etal., J Vasc Surg. 2013 Jan;57(1):194-204. doi: 10.1016/j.jvs.2012.06.083. Epub 2012 Oct 13.
36. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
37. [The expression of VCAM-1 in organs of rats died of anaphylactic shock]. Li XJ, etal., Fa Yi Xue Za Zhi. 2011 Apr;27(2):87-90.
38. The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Lutz J, etal., J Mol Med. 2008 Dec;86(12):1329-39. Epub 2008 Sep 24.
39. Soluble cell adhesion molecules in hypertensive concentric left ventricular hypertrophy. Malmqvist K, etal., J Hypertens. 2002 Aug;20(8):1563-9.
40. NF-kappa B is activated during acute inflammation in vivo in association with elevated endothelial cell adhesion molecule gene expression and leukocyte recruitment. Manning AM, etal., J Inflamm. 1995;45(4):283-96.
41. [Concentration of serum soluble forms of ICAM-1 (sVCAM-1) and VCAM-1 (sVCAM-1) in patients with chronic pancreatitis and in patients with pancreatic carcinoma] Markocka-Maczka K Wiad Lek. 2003;56(3-4):147-51.
42. Serum levels of adhesion molecules correlate with insulin resistance. Matsumoto K, etal., Atherosclerosis. 2002 Mar;161(1):243-4.
43. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
44. Development of progressive aortic vasculopathy in a rat model of aging. Miller SJ, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2634-43. Epub 2007 Sep 14.
45. Effect of irradiation on gene expression of rat liver adhesion molecules: in vivo and in vitro studies. Moriconi F, etal., Strahlenther Onkol. 2009 Jul;185(7):460-8. Epub 2009 Aug 28.
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. The effects of short-term, rapid glycemic control on the peroneal nerve function and serum VCAM-1 and AGE in type 2 diabetic patients in Malaysia. Norlinah MI, etal., Indian J Med Sci. 2009 Apr;63(4):131-8.
48. Role of tumor endothelium in CD4+ CD25+ regulatory T cell infiltration of human pancreatic carcinoma. Nummer D, etal., J Natl Cancer Inst. 2007 Aug 1;99(15):1188-99. Epub 2007 Jul 24.
49. Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. O'Sullivan JB, etal., J Neuroimmunol. 2010 Mar 30;220(1-2):34-42. doi: 10.1016/j.jneuroim.2009.12.007. Epub 2010 Jan 12.
50. Endothelial activation markers in anemic non-dialysis chronic kidney disease patients. Patel TV, etal., Nephron Clin Pract. 2008;110(4):c244-50. doi: 10.1159/000167872. Epub 2008 Oct 31.
51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
53. Soluble vascular cell adhesion molecule-1 indicates SLE disease activity and specific organ involvement. Pizarro S, etal., Rev Alerg Mex. 2007 Nov-Dec;54(6):189-95.
54. VCAM-1 siRNA reduces neointimal formation after surgical mechanical injury of the rat carotid artery. Qu Y, etal., J Vasc Surg. 2009 Dec;50(6):1452-8. doi: 10.1016/j.jvs.2009.08.050.
55. Increased plasma adiponectin closely associates with vascular endothelial dysfunction in type 2 diabetic patients with diabetic nephropathy. Ran J, etal., Diabetes Res Clin Pract. 2010 May;88(2):177-83. doi: 10.1016/j.diabres.2010.01.021. Epub 2010 Feb 6.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Correlation between the levels of circulating adhesion molecules and atherosclerosis in type-2 diabetic normotensive patients: Circulating adhesion molecules and atherosclerosis. Rubio-Guerra AF, etal., Cell Adh Migr. 2009 Oct 7;3(4).
60. [Levels of soluble adhesion molecules among normal and hypertensive type 2 diabetic patients]. Rubio-Guerra AF, etal., Gac Med Mex. 2008 Jan-Feb;144(1):11-4.
61. Differential resolution of inflammation and recovery after renal ischemia-reperfusion injury in Brown Norway compared with Sprague Dawley rats. Saenz-Morales D, etal., Kidney Int. 2010 May;77(9):781-93. doi: 10.1038/ki.2010.10. Epub 2010 Feb 17.
62. Novel risk factors in long-term hypertension incidence in type 1 diabetes mellitus. Sahakyan K, etal., Am Heart J. 2010 Jun;159(6):1074-80. doi: 10.1016/j.ahj.2010.03.023.
63. A nuclear factor-kappaB inhibitor pyrrolidine dithiocarbamate ameliorates pulmonary hypertension in rats. Sawada H, etal., Chest. 2007 Oct;132(4):1265-74.
64. Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. Shirpoor A, etal., Vascul Pharmacol. 2012 Sep;57(2-4):72-7. Epub 2012 Apr 12.
65. Urine VCAM-1 as a marker of renal pathology activity index in lupus nephritis. Singh S, etal., Arthritis Res Ther. 2012 Jul 13;14(4):R164.
66. Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis. Smeding L, etal., Respir Res. 2012 Mar 20;13:23. doi: 10.1186/1465-9921-13-23.
67. Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats. Sun L, etal., Chin Med J (Engl). 2008 Nov 20;121(22):2305-11.
68. Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation. Tan HW, etal., Acta Pharmacol Sin. 2008 Sep;29(9):1051-9.
69. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Taylor JG 6th, etal., Blood 2002 Dec 15;100(13):4303-9. Epub 2002 Aug 15.
70. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
71. Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Tikellis C, etal., Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.
72. Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism-induced polystyrene microspheres in rats. Toba M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Mar;298(3):L297-303. doi: 10.1152/ajplung.90237.2008. Epub 2009 Nov 13.
73. Type 1 diabetes increases the expression of proinflammatory cytokines and adhesion molecules in the artery wall of candidate patients for kidney transplantation. Trinanes J, etal., Diabetes Care. 2012 Feb;35(2):427-33. doi: 10.2337/dc11-1665. Epub 2011 Dec 30.
74. Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Wang C, etal., Thromb Res. 2013 Jan;131(1):e31-8. doi: 10.1016/j.thromres.2012.11.002. Epub 2012 Nov 28.
75. Intervention with cilostazol attenuates renal inflammation in streptozotocin-induced diabetic rats. Wang F, etal., Life Sci. 2008 Dec 19;83(25-26):828-35. Epub 2008 Oct 21.
76. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
77. Nucleotide sequence of rat vascular cell adhesion molecule-1 cDNA. Williams AJ, etal., Biochim Biophys Acta 1992 Jun 15;1131(2):214-6.
78. Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart. Wingerd KL, etal., J Neurosci 2002 Dec 15;22(24):10772-80.
79. [Impact of fenofibrate on No and endothelial VCAM-1 expression in hyperlipidemic rats] Wu J, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Dec;27(12):1872-4.
80. Effects of total flavonoids from Dracocephalum moldavica on the proliferation, migration, and adhesion molecule expression of rat vascular smooth muscle cells induced by TNF-alpha. Xing J, etal., Pharm Biol. 2013 Jan;51(1):74-83. doi: 10.3109/13880209.2012.711839. Epub 2012 Oct 4.
81. Microvascular complications are associated with low levels of maternal sE-selectin and sVCAM-1 in pregnancy complicated with pregestational diabetes mellitus. Zawiejska A, etal., Diabetes Res Clin Pract. 2010 May;88(2):164-70. doi: 10.1016/j.diabres.2010.01.011. Epub 2010 Feb 2.
Additional References at PubMed
PMID:1377228   PMID:1381355   PMID:1715889   PMID:2688898   PMID:7530222   PMID:7539357   PMID:8145052   PMID:8562500   PMID:9290466   PMID:11078691   PMID:12021259   PMID:12082081  
PMID:12160302   PMID:12477932   PMID:15001568   PMID:15220135   PMID:15366013   PMID:15879141   PMID:15919506   PMID:16809613   PMID:17064783   PMID:17599409   PMID:17670746   PMID:18032781  
PMID:18095572   PMID:18221587   PMID:18308860   PMID:19738201   PMID:19922364   PMID:19997643   PMID:20197615   PMID:20687137   PMID:20936719   PMID:21121367   PMID:21184129   PMID:21464233  
PMID:21961520   PMID:22195873   PMID:22351665   PMID:22562815   PMID:22627111   PMID:23058024   PMID:23376485   PMID:23474851   PMID:23533145   PMID:23620790   PMID:24100802   PMID:24289084  
PMID:25182537   PMID:25708190   PMID:25868755   PMID:26351298   PMID:26531813   PMID:27072237   PMID:27620662   PMID:29789783   PMID:30431687   PMID:34022890   PMID:34492249   PMID:36273220  


Genomics

Comparative Map Data
Vcam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22204,038,120 - 204,057,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2204,038,114 - 204,057,958 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2211,702,572 - 211,722,182 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02209,587,221 - 209,606,807 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02204,404,257 - 204,423,843 (-)NCBIRnor_WKY
Rnor_6.02219,071,193 - 219,090,931 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2219,071,193 - 219,097,619 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02237,158,192 - 237,177,779 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42212,277,654 - 212,297,376 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12212,240,407 - 212,260,130 (-)NCBI
Celera2196,537,457 - 196,557,044 (-)NCBICelera
RH 3.4 Map21480.6RGD
Cytogenetic Map2q41NCBI
VCAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381100,719,742 - 100,739,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1100,719,742 - 100,739,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371101,185,298 - 101,204,601 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361100,957,885 - 100,977,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341100,897,317 - 100,916,620NCBI
Celera199,446,448 - 99,465,752 (+)NCBICelera
Cytogenetic Map1p21.2NCBI
HuRef199,309,886 - 99,329,291 (+)NCBIHuRef
CHM1_11101,301,307 - 101,320,707 (+)NCBICHM1_1
T2T-CHM13v2.01100,568,139 - 100,587,438 (+)NCBIT2T-CHM13v2.0
Vcam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393115,903,669 - 115,923,337 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3115,903,598 - 115,923,337 (-)EnsemblGRCm39 Ensembl
GRCm383116,110,020 - 116,129,688 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3116,109,949 - 116,129,688 (-)EnsemblGRCm38mm10GRCm38
MGSCv373115,812,938 - 115,832,606 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363116,102,024 - 116,121,692 (-)NCBIMGSCv36mm8
Celera3122,538,966 - 122,558,635 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map350.17NCBI
Vcam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554355,390,751 - 5,411,691 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554355,390,745 - 5,410,025 (+)NCBIChiLan1.0ChiLan1.0
VCAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11102,091,121 - 102,108,494 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1102,091,336 - 102,107,732 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01103,377,815 - 103,395,118 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
VCAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1649,341,669 - 49,359,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl649,342,151 - 49,359,933 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha652,013,558 - 52,031,171 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0649,686,812 - 49,704,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl649,686,818 - 49,705,286 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1649,380,130 - 49,397,749 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0649,359,940 - 49,377,559 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0649,789,615 - 49,807,229 (-)NCBIUU_Cfam_GSD_1.0
Vcam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058110,980,297 - 110,997,141 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936748785,455 - 803,048 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936748785,491 - 802,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VCAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4117,496,920 - 117,511,222 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14117,496,914 - 117,511,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24129,040,268 - 129,054,581 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VCAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12032,616,425 - 32,635,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2032,615,333 - 32,635,862 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603825,428,596 - 25,448,051 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vcam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248573,606,431 - 3,627,063 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248573,606,573 - 3,625,991 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vcam1
110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:60
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000019377
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat

Markers in Region
AW524920  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,038,603 - 204,038,765 (+)MAPPERmRatBN7.2
Rnor_6.02219,071,677 - 219,071,838NCBIRnor6.0
Rnor_5.02237,158,685 - 237,158,846UniSTSRnor5.0
RGSC_v3.42212,278,138 - 212,278,299UniSTSRGSC3.4
Celera2196,537,941 - 196,538,102UniSTS
RH 3.4 Map21478.8UniSTS
Cytogenetic Map2q41UniSTS
RH94527  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,038,424 - 204,038,568 (+)MAPPERmRatBN7.2
Rnor_6.02219,071,498 - 219,071,641NCBIRnor6.0
Rnor_5.02237,158,506 - 237,158,649UniSTSRnor5.0
RGSC_v3.42212,277,959 - 212,278,102UniSTSRGSC3.4
Celera2196,537,762 - 196,537,905UniSTS
RH 3.4 Map21480.6UniSTS
Cytogenetic Map2q41UniSTS
RH141550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,038,215 - 204,038,431 (+)MAPPERmRatBN7.2
Rnor_6.02219,071,289 - 219,071,504NCBIRnor6.0
Rnor_5.02237,158,297 - 237,158,512UniSTSRnor5.0
RGSC_v3.42212,277,750 - 212,277,965UniSTSRGSC3.4
Celera2196,537,553 - 196,537,768UniSTS
RH 3.4 Map21482.9UniSTS
Cytogenetic Map2q41UniSTS
PMC209298P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22204,051,846 - 204,052,133 (+)MAPPERmRatBN7.2
Rnor_6.02219,091,699 - 219,091,985NCBIRnor6.0
Rnor_6.02219,084,924 - 219,085,210NCBIRnor6.0
Rnor_5.02237,171,682 - 237,171,968UniSTSRnor5.0
Rnor_5.02237,178,457 - 237,178,743UniSTSRnor5.0
RGSC_v3.42212,291,369 - 212,291,655UniSTSRGSC3.4
Celera2196,551,051 - 196,551,337UniSTS
Cytogenetic Map2q41UniSTS


Related Rat Strains
The following Strains have been annotated to Vcam1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 22 37 27 19 27 66 27 13 11
Low 1 21 20 14 14 8 11 8 8 28 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019377   ⟹   ENSRNOP00000019377
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,052,303 - 204,057,870 (-)Ensembl
Rnor_6.0 Ensembl2219,071,921 - 219,090,874 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077972   ⟹   ENSRNOP00000071676
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,038,114 - 204,057,958 (-)Ensembl
Rnor_6.0 Ensembl2219,071,208 - 219,094,730 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078806   ⟹   ENSRNOP00000071423
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2204,038,114 - 204,057,870 (-)Ensembl
Rnor_6.0 Ensembl2219,071,193 - 219,097,619 (-)Ensembl
RefSeq Acc Id: NM_012889   ⟹   NP_037021
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22204,038,120 - 204,057,852 (-)NCBI
Rnor_6.02219,071,193 - 219,090,931 (-)NCBI
Rnor_5.02237,158,192 - 237,177,779 (-)NCBI
RGSC_v3.42212,277,654 - 212,297,376 (-)RGD
Celera2196,537,457 - 196,557,044 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037021 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42332 (Get FASTA)   NCBI Sequence Viewer  
  AAH89812 (Get FASTA)   NCBI Sequence Viewer  
  CAA45254 (Get FASTA)   NCBI Sequence Viewer  
  EDL82023 (Get FASTA)   NCBI Sequence Viewer  
  P29534 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037021   ⟸   NM_012889
- Peptide Label: precursor
- UniProtKB: Q63669 (UniProtKB/Swiss-Prot),   P29534 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071676   ⟸   ENSRNOT00000077972
RefSeq Acc Id: ENSRNOP00000019377   ⟸   ENSRNOT00000019377
RefSeq Acc Id: ENSRNOP00000071423   ⟸   ENSRNOT00000078806
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29534-F1-model_v2 AlphaFold P29534 1-739 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691702
Promoter ID:EPDNEW_R2227
Type:single initiation site
Name:Vcam1_2
Description:vascular cell adhesion molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2228  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02219,090,963 - 219,091,023EPDNEW
RGD ID:13691714
Promoter ID:EPDNEW_R2228
Type:single initiation site
Name:Vcam1_1
Description:vascular cell adhesion molecule 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2227  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02219,097,651 - 219,097,711EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3952 AgrOrtholog
BioCyc Gene G2FUF-51507 BioCyc
Ensembl Genes ENSRNOG00000014333 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019377.4 UniProtKB/TrEMBL
  ENSRNOP00000071423 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071676.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019377.6 UniProtKB/TrEMBL
  ENSRNOT00000077972.2 UniProtKB/TrEMBL
  ENSRNOT00000078806 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7364929 IMAGE-MGC_LOAD
InterPro ICAM_VCAM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VCAM-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25361 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108734 IMAGE-MGC_LOAD
NCBI Gene 25361 ENTREZGENE
PANTHER PTHR13771:SF14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vcam1 PhenoGen
PRINTS ICAMVCAM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VCAM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206984
UniProt A0A0G2K127_RAT UniProtKB/TrEMBL
  A0A8L2Q9Q0_RAT UniProtKB/TrEMBL
  P29534 ENTREZGENE
  Q63669 ENTREZGENE
  VCAM1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5FVS3 UniProtKB/Swiss-Prot
  Q63669 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Vcam1  vascular cell adhesion molecule 1  LOC100912479  vascular cell adhesion protein 1-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100912479  vascular cell adhesion protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Vcam1  Vascular cell adhesion molecule 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular endothelium, heart muscles 628409
gene_pathway recognized by lymphoid cells via alpha 4 integrins 628409
gene_process cytokine-induced protein during tissue inflammation 628409
gene_process may induce neurite outgrowth by sympathetic neurons 628409
gene_process may be involved in sympathetic innervation of heart along with alpha 4 integrins 628409
gene_product member of IgG superfamily 628409