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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDProgesterone results in increased expression of VCAM1 mRNAPMID:21770760
Vcam1increases expressionISOVCAM1 (Homo sapiens)6480464CTDProgesterone results in increased expression of VCAM1 mRNAPMID:18692832
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] results in increased expression of VCAM1 mRNA; Mifepristone inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; Org 31710 inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]PMID:15358673 PMID:18692832
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