RGD Reference Report - Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis.

Authors: Ibrahim, A  Aziz, M  Hassan, A  Mbodji, K  Collasse, E  Coeffier, M  Bounoure, F  Savoye, G  Dechelotte, P  Marion-Letellier, R 
Citation: Ibrahim A, etal., Nutrition. 2012 Jul;28(7-8):799-802. doi: 10.1016/j.nut.2011.10.008. Epub 2012 Jan 20.
RGD ID: 7207796
Pubmed: PMID:22261574   (View Abstract at PubMed)
DOI: DOI:10.1016/j.nut.2011.10.008   (Journal Full-text)

OBJECTIVE: The omega-3 polyunsaturated fatty acid therapy in inflammatory bowel disease is focused on the effects on fish oil-derived polyunsaturated fatty acids. We speculated that a vegetal oil rich in alpha-linolenic acid (ALA) might also inhibit colitis. Therefore, we evaluated whether dietary ALA would decrease the expression of adhesion molecules by inducing the protective enzyme heme oxygenase-1 (HO-1) in a rat colitis model. METHODS: Colitis was induced at day 0 by an intrarectal injection of 2-4-6-trinitrobenzen sulfonic acid (TNBS), whereas control rats received the vehicle. Rats were fed an ALA-rich formula 450 mg . kg(-)(1) . d(-)(1), whereas the other colitic group (TNBS) and the control group were fed an isocaloric corn oil formula for 14 d (from day -7 to day 7). The colonic expressions of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor A receptor-2 (VEGFR2), and HO-1 were studied by immunohistochemistry. RESULTS: The ALA-rich diet significantly decreased the expression of ICAM-1, VCAM-1, and VEGFR-2 compared the TNBS group, but it did not affect the expression of HO-1. CONCLUSION: A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. Further studies are required to evaluate its therapeutic potential in inflammatory bowel disease as an alternative to fish oil.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
colitis  ISOHmox1 (Rattus norvegicus)7207796; 7207796protein:increased expression:colon:RGD 
colitis  IEP 7207796; 7207796; 7207796; 7207796protein:increased expression:colon:RGD 
colitis  ISOIcam1 (Rattus norvegicus)7207796; 7207796protein:increased expression:colon:RGD 
colitis  ISOKdr (Rattus norvegicus)7207796; 7207796protein:increased expression:colon:RGD 
colitis  ISOVcam1 (Rattus norvegicus)7207796; 7207796protein:increased expression:colon:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmox1  (heme oxygenase 1)
Icam1  (intercellular adhesion molecule 1)
Kdr  (kinase insert domain receptor)
Vcam1  (vascular cell adhesion molecule 1)

Genes (Mus musculus)
Hmox1  (heme oxygenase 1)
Icam1  (intercellular adhesion molecule 1)
Kdr  (kinase insert domain protein receptor)
Vcam1  (vascular cell adhesion molecule 1)

Genes (Homo sapiens)
HMOX1  (heme oxygenase 1)
ICAM1  (intercellular adhesion molecule 1)
KDR  (kinase insert domain receptor)
VCAM1  (vascular cell adhesion molecule 1)


Additional Information