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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDStreptozocin results in increased expression of VCAM1 mRNA; Streptozocin results in increased expression of VCAM1 proteinPMID:16129698 PMID:16139267 PMID:16979161 PMID:17589825 PMID:25199697
Vcam1multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]; esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]PMID:16129698 PMID:16139267 PMID:16979161 PMID:17589825 PMID:25199697 PMID:28946194
Vcam1increases expressionISOVcam1 (Mus musculus)6480464CTDStreptozocin results in increased expression of VCAM1 mRNAPMID:28700904
Vcam1multiple interactionsISOVcam1 (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 protein; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]; sulforaphane inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of VCAM1 protein]PMID:24707343 PMID:28700904
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