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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNAPMID:22903158
Vcam1increases expressionISOVcam1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNA; Lipopolysaccharides results in increased expression of VCAM1 proteinPMID:12892526 PMID:19330446 PMID:21300114 PMID:22185406 PMID:23170834 PMID:27183587
Vcam1increases expressionISOVCAM1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of VCAM1 mRNA; Lipopolysaccharides results in increased expression of VCAM1 proteinPMID:12615669 PMID:15358673 PMID:16317058 PMID:19426978 PMID:21371465 PMID:22007554 PMID:22442067 PMID:27183587 PMID:29128401 PMID:32017913 PMID:32679256 PMID:35811015 PMID:38374343
Vcam1multiple interactionsISOVcam1 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA; [Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 protein; [Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of VCAM1 mRNA; caryophyllene inhibits the reaction [[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 mRNA]; caryophyllene inhibits the reaction [[Lipopolysaccharides co-treated with Dietary Fats] results in increased expression of VCAM1 protein]; Cathelicidins inhibits the reaction [[Shiga Toxin 2 co-treated with Lipopolysaccharides] results in increased expression of VCAM1 mRNA]; Cycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]PMID:12892526 PMID:21300114 PMID:21731756 PMID:22185406 PMID:23170834 PMID:28624443
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTD1-(4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl)-3-methylcyclohexanol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; 22-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; 24,25-epoxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; gingerenone A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; gingerenone A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of VCAM1 protein; MAVS protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Medroxyprogesterone Acetate inhibits the reaction [Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; Mifepristone inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Org 31710 inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]]; Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; RIGI protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; SMIM20 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; sodium bisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]; T0901317 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]; TLR4 protein affects the reaction [RIGI protein affects the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VCAM1 protein]PMID:12615669 PMID:15358673 PMID:16317058 PMID:19426978 PMID:21035309 PMID:21371465 PMID:22007554 PMID:22442067 PMID:27183587 PMID:28513976 PMID:29128401 PMID:32017913 PMID:35811015 PMID:9846848
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