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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEnalapril results in decreased expression of ICAM1 protein

PMID:14716214
decreases expressionISORGD:107566480464CTDEnalapril results in decreased expression of ICAM1 protein modified form

PMID:17347482
multiple interactionsISORGD:107566480464CTD[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA

PMID:25037058
multiple interactionsISORGD:696596480464CTDEnalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]

PMID:28973481
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.