RGD Reference Report - Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease. - Rat Genome Database

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Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease.

Authors: Verity, DH  Vaughan, RW  Kondeatis, E  Madanat, W  Zureikat, H  Fayyad, F  Marr, JE  Kanawati, CA  Wallace, GR  Stanford, MR 
Citation: Verity DH, etal., Eur J Immunogenet. 2000 Apr;27(2):73-6.
RGD ID: 8158123
Pubmed: (View Article at PubMed) PMID:10792421

Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behcet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.

Annotation

Disease Annotations    
Behcet's disease  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)


Additional Information