RGD Reference Report - Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with allergic rhinoconjunctivitis. - Rat Genome Database

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Soluble intercellular adhesion molecule-1 (sICAM-1) in patients with allergic rhinoconjunctivitis.

Authors: Turgay, M  Keskin, G  Kminkli, G  Senturk, T  Tutkak, H  Duman, M  Tokgoz, G 
Citation: Turgay M, etal., Allergol Immunopathol (Madr). 1996 May-Jun;24(3):129-31.
RGD ID: 8547686
Pubmed: PMID:8766745   (View Abstract at PubMed)

Intercellular adhesion molecule-1 (ICAM-1), a member of immunoglobulin supergene family with a five-domain structure, is known to play an important role in inflammatory disease. We measured levels of soluble ICAM-1 in sera of 25 patients with allergic rhinoconjunctivitis (7 male, 18 female: age range 14-47 years, mean 29.8 +/- 9.2) and 20 healthy subjects (11 male, 9 female: age range 22-48 years, mean: 33.3 +/- 7.6). All allergic patients had positive history, positive skin prick test and conjunctival provocation test, and radioallergosorbent test for specific allergens. Soluble ICAM-1 in serum samples was determinated by ELISA. The mean serum sICAM-1 levels, in healthy subjects was 193.3 +/- 68.8 ng/ml and in patients with allergic rhinoconjunctivitis was 212.6 +/- 50.9 ng/ml. There were no difference in sICAM-1 levels in both of the groups (P > 0.05). In male patients with allergic rhinoconjunctivitis, sICAM-1 levels (mean: 234.5 +/- 55.0 ng/ml) were higher compared to female patients with allergic rhinoconjunctivitis (mean: 204.1 +/- 48.1 ng/ml) and control group (P < 0.05 and P < 0.05 respectively). Soluble ICAM-1 levels were high in patients with allergic rhinoconjunctivitis who had high level of symptom score.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
allergic conjunctivitis  IEP 8547686 RGD 
allergic conjunctivitis  ISOICAM1 (Homo sapiens)8547686; 8547686 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)


Additional Information