Icam1 (intercellular adhesion molecule 1) - Rat Genome Database

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Gene: Icam1 (intercellular adhesion molecule 1) Chinchilla lanigera
Symbol: Icam1
Name: intercellular adhesion molecule 1
RGD ID: 8709730
Description: ENCODES a protein that exhibits integrin binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); adhesion of symbiont to host (ortholog); cell adhesion (ortholog); PARTICIPATES IN eicosanoid signaling pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute Necrotizing Pancreatitis (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
Acute Necrotizing Pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Animal Hepatitis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Brain Death  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchus carcinoma  (ISO)
bullous pemphigoid  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic ulcer of skin  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
contact dermatitis  (ISO)
Crohn's disease  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse large B-cell lymphoma  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Enteritis  (ISO)
Eosinophilic Myocarditis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
Intimal Hyperplasia  (ISO)
iridocyclitis  (ISO)
Jaundice  (ISO)
Kidney Neoplasms  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
Lymphocytic Myocarditis  (ISO)
malaria  (ISO)
melanoma  (ISO)
Mercury Poisoning  (ISO)
mesenteric vascular occlusion  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prinzmetal angina  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinopathy of prematurity  (ISO)
rheumatic fever  (ISO)
rheumatic myocarditis  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
venous insufficiency  (ISO)
Viral Myocarditis  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
adhesion of symbiont to host  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell aging  (ISO)
cell-cell adhesion  (ISO)
cellular response to alkaloid  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
establishment of endothelial barrier  (ISO)
establishment of endothelial intestinal barrier  (ISO)
establishment of Sertoli cell barrier  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO)
membrane to membrane docking  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
ovarian follicle development  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of vasoconstriction  (ISO)
receptor-mediated virion attachment to host cell  (ISO)
regulation of cell shape  (ISO)
regulation of ruffle assembly  (ISO)
response to amino acid  (ISO)
response to amphetamine  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to gonadotropin  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to ionizing radiation  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to sulfur dioxide  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
T cell antigen processing and presentation  (ISO)
T cell extravasation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View


Comparative Map Data
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBIChiLan1.0ChiLan1.0
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1910,271,093 - 10,286,615 (+)EnsemblGRCh38hg38GRCh38
GRCh381910,271,120 - 10,286,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,381,796 - 10,397,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,242,779 - 10,258,291 (+)NCBINCBI36hg18NCBI36
Build 341910,242,778 - 10,258,291NCBI
Celera1910,276,917 - 10,292,687 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,965,426 - 9,977,270 (+)NCBIHuRef
CHM1_11910,381,783 - 10,397,556 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39920,927,236 - 20,940,110 (+)NCBIGRCm39mm39
GRCm39 Ensembl920,927,281 - 20,940,113 (+)Ensembl
GRCm38921,015,940 - 21,028,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,015,985 - 21,028,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,820,404 - 20,833,241 (+)NCBIGRCm37mm9NCBIm37
MGSCv36920,766,362 - 20,779,199 (+)NCBImm8
Celera918,284,644 - 18,297,383 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.69NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2819,553,063 - 19,565,438 (+)NCBI
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
Celera820,948,090 - 20,959,852 (+)NCBICelera
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11910,484,414 - 10,500,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,484,414 - 10,500,605 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,821,402 - 9,837,021 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12050,818,715 - 50,827,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,818,715 - 50,827,914 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,688,470 - 50,697,454 (-)NCBI
ROS_Cfam_1.02051,340,345 - 51,349,327 (-)NCBI
UMICH_Zoey_3.12050,546,484 - 50,555,463 (-)NCBI
UNSW_CanFamBas_1.02050,975,237 - 50,984,210 (-)NCBI
UU_Cfam_GSD_1.02051,216,377 - 51,225,401 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118209,727,534 - 209,738,599 (-)NCBI
SpeTri2.0NW_004936659616,570 - 627,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl269,097,122 - 69,108,205 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,097,136 - 69,107,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,431,462 - 69,442,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.169,320,991 - 9,338,125 (+)NCBI
ChlSab1.1 Ensembl69,322,550 - 9,338,263 (+)Ensembl
Vero_WHO_p1.0NW_02366607410,702,922 - 10,719,213 (-)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBI



Reference Sequences
RefSeq Acc Id: ENSCLAT00000007747   ⟹   ENSCLAP00000007629
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)Ensembl
RefSeq Acc Id: XM_005405586   ⟹   XP_005405643
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBI
RefSeq Acc Id: XM_005405587   ⟹   XP_005405644
RefSeq Status:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,561,699 - 1,573,282 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005405643 (Get FASTA)   NCBI Sequence Viewer  
  XP_005405644 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005405643   ⟸   XM_005405586
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005405644   ⟸   XM_005405587
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000007629   ⟸   ENSCLAT00000007747

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005350 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000007629 ENTREZGENE
Ensembl Transcript ENSCLAT00000007747 ENTREZGENE