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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:33234
Term: vitamin E
Definition: A chromanol that is chroman-6-ol which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:696596480464CTD[Ascorbic Acid co-treated with Lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA], [Vitamin E co-treated with Bezafibrate] results in decreased expression of ICAM1 protein modified form, alpha-Tocopherol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA], alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein], Vitamin E inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA], Vitamin E inhibits the reaction [Simvastatin results in decreased expression of ICAM1 protein modified form]

PMID:14602771, PMID:22313677, PMID:23114885, PMID:25551565
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.