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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMifepristone results in decreased expression of ICAM1 mRNA

PMID:25972201
multiple interactionsISORGD:107566480464CTDMifepristone inhibits the reaction [Halothane results in increased expression of ICAM1 mRNA], Mifepristone inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of ICAM1 mRNA]]

PMID:21501669, PMID:22157104
multiple interactionsISORGD:696596480464CTDMifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Mifepristone inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]

PMID:15358673
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.