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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:60479
Term: lysophosphatidylcholine
Definition: An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.
Chemical ID: MESH:D008244
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:696596480464CTDLysophosphatidylcholines results in increased expression of ICAM1 mRNA

PMID:27257344
multiple interactionsISORGD:696596480464CTDquercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA], Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]

PMID:27257344
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.