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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dioscin
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Accession:CHEBI:74023 term browser browse the term
Definition:A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Synonyms:exact_synonym: (25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside
 related_synonym: 3-O-(Rhaalpha1-4(Rhaalpha1-2)Glcbeta)-(25R)-spirost-5-en-3beta-ol;   3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]-diosgenin;   3-O-[alpha-L-Rhap-(1->4)-[alpha-L-Rhap-(1->2)]-beta-D-Glcp]-diosgenin;   Collettiside III;   Dioscine;   Formula=C45H72O16;   InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1;   InChIKey=VNONINPVFQTJOC-ZGXDEBHDSA-N;   SMILES=[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]1(CC[C@@H](C)CO1)O2)O[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
 alt_id: CHEBI:4627
 xref: CAS:19057-60-4;   KEGG:C08897;   KNApSAcK:C00003575;   LIPID_MAPS_instance:LMST01080053
 xref_mesh: MESH:C019357
 xref: PMID:16079518;   PMID:20622501;   PMID:22231406;   PMID:22334414;   PMID:22386816;   PMID:22516057;   PMID:22895655;   PMID:22939915;   PMID:23107741;   PMID:23193420;   PMID:23238077;   PMID:23262192;   PMID:23396419;   PMID:23467827;   PMID:23552851;   PMID:23621869;   PMID:23678800;   Reaxys:77615


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dioscin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] CTD PMID:27317372 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO
EXP		 dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein CTD PMID:24680847 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] CTD PMID:27317372 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] CTD PMID:24146112 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] CTD PMID:24146112 NCBI chr12:47,154,259...47,163,580
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:24146112 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] CTD PMID:24146112 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] CTD PMID:24146112 NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] CTD PMID:35481609 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression		 ISO dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]
dioscin results in decreased expression of AKT1 mRNA
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein]		 CTD PMID:25111127 PMID:29990575 PMID:35481609 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] CTD PMID:24146112 NCBI chr18:52,208,035...52,240,293
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression ISO dioscin results in decreased expression of APAF1 mRNA CTD PMID:33359023 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] CTD PMID:24146112 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO dioscin results in increased expression of BAD mRNA CTD PMID:33359023 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein]
dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein		 CTD PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein		 CTD PMID:22334414 PMID:22939915 PMID:33359023 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein CTD PMID:29990575 PMID:33359023 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression		 ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein
dioscin results in increased expression of BCL2 protein		 CTD PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO [Acetaminophen co-treated with dioscin] results in increased expression of BID protein
dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein		 CTD PMID:22334414 PMID:22939915 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression ISO dioscin results in increased expression of BIRC5 mRNA CTD PMID:29990575 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
decreases expression		 EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
dioscin results in increased activity of CASP3 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]
dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein
dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein		 CTD PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression ISO dioscin results in increased expression of CASP7 mRNA CTD PMID:29990575 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity
increases expression
decreases expression
multiple interactions		 ISO dioscin results in increased activity of CASP8 protein
dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein
dioscin results in decreased expression of CASP8 mRNA
dioscin results in decreased expression of and results in increased cleavage of CASP8 protein		 CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
decreases expression		 EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein]
dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein
dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein		 CTD PMID:24146112 PMID:29990575 PMID:33359023 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccna2 cyclin A2 decreases expression ISO dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein CTD PMID:33359023 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein CTD PMID:29990575 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression
decreases expression		 ISO dioscin results in increased expression of CCND1 mRNA
dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein		 CTD PMID:29990575 PMID:33359023 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein CTD PMID:33359023 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein CTD PMID:29990575 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein CTD PMID:33359023 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO dioscin results in decreased expression of CDK4 mRNA CTD PMID:33359023 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein CTD PMID:33359023 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein CTD PMID:29990575 PMID:33359023 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein CTD PMID:33359023 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein CTD PMID:33359023 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein CTD PMID:33359023 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein CTD PMID:29990575 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:24146112 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA]		 CTD PMID:24742230 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO dioscin results in increased expression of CYCS mRNA CTD PMID:33359023 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] CTD PMID:24146112 NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] CTD PMID:24146112 NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO dioscin results in increased expression of DIABLO mRNA CTD PMID:29990575 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions		 ISO dioscin results in increased expression of ESR1 protein
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein]		 CTD PMID:24742230 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] CTD PMID:24742230 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein CTD PMID:22334414 PMID:33359023 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein CTD PMID:22334414 PMID:29990575 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Foxo1 forkhead box O1 increases expression ISO dioscin results in increased expression of FOXO1 mRNA CTD PMID:33359023 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] CTD PMID:27317372 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] CTD PMID:24146112 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]
dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:24146112 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] CTD PMID:35481609 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] CTD PMID:35481609 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] CTD PMID:35481609 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]
dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver]		 CTD
RGD		 PMID:24146112 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] CTD PMID:25111127 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] CTD PMID:28082111 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Krt18 keratin 18 multiple interactions ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] CTD PMID:22939915 PMID:24146112 NCBI chr 7:135,036,168...135,039,844
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166 		JBrowse link
G Lrp5 LDL receptor related protein 5 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] CTD PMID:24742230 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24146112 PMID:25111127 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO dioscin results in increased expression of MAPK8 mRNA CTD PMID:29990575 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO dioscin results in increased expression of MAPK9 mRNA CTD PMID:29990575 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] CTD PMID:22939915 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO dioscin results in decreased expression of MTOR mRNA CTD PMID:29990575 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] CTD PMID:35481609 NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO dioscin results in decreased degradation of NFKBIA protein CTD PMID:24680847 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions
increases expression		 EXP dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]
dioscin results in increased expression of NR0B2 mRNA		 CTD PMID:27317372 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver]		 CTD
RGD		 PMID:28082111 PMID:29091898 RGD:15090820 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
dioscin results in increased expression of PARP1 mRNA
dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein		 CTD PMID:24146112 PMID:29990575 PMID:33359023 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta decreases expression ISO dioscin results in decreased expression of PIK3CB mRNA CTD PMID:29990575 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pnp purine nucleoside phosphorylase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] CTD PMID:22939915 NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO		 dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:24146112 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] CTD PMID:22939915 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 increases expression ISO dioscin results in increased expression of PRKAB1 mRNA CTD PMID:29990575 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] RGD PMID:29091898 RGD:15090820 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] CTD PMID:25111127 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] CTD PMID:28082111 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgn regucalcin multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] CTD PMID:22939915 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO dioscin results in decreased expression of RPS6KB1 mRNA CTD PMID:29990575 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] CTD PMID:27317372 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP dioscin results in increased expression of SLCO1A2 mRNA CTD PMID:27317372 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases expression		 EXP dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]
dioscin results in increased expression of SLCO1B2 mRNA		 CTD PMID:27317372 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Suox sulfite oxidase multiple interactions ISO dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] CTD PMID:22939915 NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,103,151...1,107,038 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein]
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:35481609 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]
dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]]
dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein
dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver]		 CTD
RGD		 PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 More... RGD:15090820 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions		 ISO dioscin results in increased expression of TNFRSF11B mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]		 CTD PMID:24742230 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein CTD PMID:22334414 PMID:29990575 PMID:33359023 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO dioscin results in increased expression of TNFRSF25 mRNA CTD PMID:29990575 PMID:33359023 NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions		 ISO dioscin results in decreased expression of TNFSF11 mRNA
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA]		 CTD PMID:24742230 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO
EXP		 dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein]
dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein		 CTD PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain increases expression ISO dioscin results in increased expression of TRADD mRNA CTD PMID:29990575 PMID:33359023 NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO dioscin results in increased expression of TRAF1 protein CTD PMID:22334414 NCBI chr 3:38,607,707...38,639,641
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:25111127 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO dioscin results in increased expression of WEE1 mRNA CTD PMID:29990575 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      application 19697
        anti-inflammatory agent 16678
          dioscin 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      carbon group element atom 19763
                        carbon atom 19760
                          organic molecular entity 19760
                            heteroorganic entity 19521
                              organochalcogen compound 19282
                                organooxygen compound 19197
                                  carbohydrates and carbohydrate derivatives 15309
                                    carbohydrate 15309
                                      carbohydrate derivative 14335
                                        glycosyl compound 13075
                                          glycoside 11848
                                            saponin 501
                                              steroid saponin 369
                                                spirostanyl glycoside 117
                                                  dioscin 107
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