RGD Reference Report - Effects of monoclonal antibodies to adhesion molecules on eosinophilic myocarditis in Toxocara canis-infected CBA/J mice. - Rat Genome Database

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Effects of monoclonal antibodies to adhesion molecules on eosinophilic myocarditis in Toxocara canis-infected CBA/J mice.

Authors: Hokibara, S  Takamoto, M  Isobe, M  Sugane, K 
Citation: Hokibara S, etal., Clin Exp Immunol. 1998 Nov;114(2):236-44.
RGD ID: 13702914
Pubmed: PMID:9822282   (View Abstract at PubMed)
PMCID: PMC1905108   (View Article at PubMed Central)

Eosinophilic myocarditis followed by fibrosis of the cardiac muscle was observed in addition to peripheral blood eosinophilia in CBA/J mice infected with Toxocara canis. The infected mice were used as an experimental model of eosinophilic endomyocarditis associated with hypereosinophilic syndrome. Effects of in vivo treatment with MoAbs to adhesion molecules on eosinophilic myocarditis were examined using this experimental model. Expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells of capillaries in myocardium were increased 1 and 2 weeks after infection. Infiltration of very late antigen (VLA)-4+ and/or CD11a+ cells into the cardiac muscles was also observed 1 and 2 weeks after infection. Infiltration of eosinophils into the heart was significantly suppressed by anti-CD18 MoAb and anti-VLA-4 MoAb, and focal fibrosis of the cardiac muscle was also significantly suppressed by combined administration of anti-CD18 and anti-ICAM-1 MoAbs. These results indicate that adhesion molecules may play important roles in eosinophilic myocarditis, and that blockade of interaction between adhesion molecules and their ligands may help to control it.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ICAM1HumanEosinophilic Myocarditis treatmentISOIcam1 (Mus musculus) RGD 
ITGB2HumanEosinophilic Myocarditis treatmentISOItgb2 (Mus musculus) RGD 
Icam1RatEosinophilic Myocarditis treatmentISOIcam1 (Mus musculus) RGD 
Icam1MouseEosinophilic Myocarditis treatmentIMP  RGD 
Itgb2RatEosinophilic Myocarditis treatmentISOItgb2 (Mus musculus) RGD 
Itgb2MouseEosinophilic Myocarditis treatmentIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)
Itgb2  (integrin subunit beta 2)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)
Itgb2  (integrin beta 2)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)
ITGB2  (integrin subunit beta 2)


Additional Information