Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Itgb2 (integrin beta 2) Mus musculus
Symbol: Itgb2
Name: integrin beta 2
Description: Exhibits amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including activated T cell proliferation; endocytosis; and leukocyte migration. Localizes to the cell surface; integrin alphaM-beta2 complex; and membrane raft. Predicted to colocalize with the cytoplasmic region. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Orthologous to human ITGB2 (integrin subunit beta 2); PARTICIPATES IN hypoxia inducible factor pathway; integrin mediated signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1,1-dichloroethene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2E6; AI528527; Cd18; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17
Homo sapiens (human) : ITGB2 (integrin subunit beta 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb2 (integrin subunit beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb2 (integrin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB2 (integrin subunit beta 2)
Canis lupus familiaris (dog) : ITGB2 (integrin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb2 (integrin subunit beta 2)
Sus scrofa (pig) : ITGB2 (integrin subunit beta 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381077,530,329 - 77,565,708 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371076,993,093 - 77,028,419 (+)NCBIGRCm37mm9NCBIm37
MGSCv361076,985,685 - 77,009,099 (+)NCBImm8
Celera1078,572,639 - 78,608,564 (+)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itgb2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313695
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.