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Gene: Itgb2 (integrin beta 2) Mus musculus
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Symbol: Itgb2
Name: integrin beta 2
Description: Exhibits amyloid-beta binding activity and complement component C3b binding activity. Contributes to cargo receptor activity. Involved in several processes, including activated T cell proliferation; endocytosis; and leukocyte migration. Localizes to the cell surface; integrin alphaM-beta2 complex; and membrane raft. Predicted to colocalize with the cytoplasmic region. Used to study leukocyte adhesion deficiency 1 and psoriasis. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Is expressed in several structures, including alimentary system; genitourinary system; heart and pericardium; hemolymphoid system; and nervous system. Orthologous to human ITGB2 (integrin subunit beta 2); PARTICIPATES IN hypoxia inducible factor pathway; integrin mediated signaling pathway; Entamoebiasis pathway; INTERACTS WITH 1,1-dichloroethene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2E6; AI528527; Cd18; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17
Orthologs:
Homo sapiens (human) : ITGB2 (integrin subunit beta 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itgb2 (integrin subunit beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb2 (integrin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB2 (integrin subunit beta 2)
Canis lupus familiaris (dog) : ITGB2 (integrin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb2 (integrin subunit beta 2)
Sus scrofa (pig) : ITGB2 (integrin subunit beta 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381077,530,329 - 77,565,708 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371076,993,093 - 77,028,419 (+)NCBIGRCm37mm9NCBIm37
MGSCv361076,985,685 - 77,009,099 (+)NCBImm8
Celera1078,572,639 - 78,608,564 (+)NCBICelera
Cytogenetic Map10 C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Itgb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313695
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.