Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: ITGB2 (integrin subunit beta 2) Homo sapiens
Analyze
Symbol: ITGB2
Name: integrin subunit beta 2
Description: This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD18; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta chain, beta 2; integrin beta-2; integrin, beta 2 (antigen cd18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1; MAC-1; macrophage antigen 1 (mac-1) beta subunit); MF17; MFI7
Orthologs:
Mus musculus (house mouse) : Itgb2 (integrin beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgb2 (integrin subunit beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb2 (integrin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB2 (integrin subunit beta 2)
Canis lupus familiaris (dog) : ITGB2 (integrin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb2 (integrin subunit beta 2)
Sus scrofa (pig) : ITGB2 (integrin subunit beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,885,949 - 44,928,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372146,305,864 - 46,348,753 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,130,296 - 45,165,303 (-)NCBINCBI36hg18NCBI36
Build 342145,130,313 - 45,165,232NCBI
Celera2131,412,498 - 31,455,256 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2131,679,225 - 31,721,357 (-)NCBIHuRef
CHM1_12145,866,651 - 45,909,384 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ITGB2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313694
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.