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Gene: ITGB2 (integrin subunit beta 2) Homo sapiens
Symbol: ITGB2
Name: integrin subunit beta 2
RGD ID: 1313694
Description: Exhibits several functions, including ICAM-3 receptor activity; heat shock protein binding activity; and protein kinase binding activity. Predicted to contribute to cargo receptor activity. Involved in several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of neutrophil degranulation. Localizes to cell surface; integrin alphaL-beta2 complex; and plasma membrane raft. Colocalizes with cytoplasmic region. Implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Biomarker of Vogt-Koyanagi-Harada disease and myocarditis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD18; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; integrin beta chain, beta 2; integrin beta-2; integrin, beta 2 (antigen cd18 (p95), lymphocyte function-associated antigen 1; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1; MAC-1; macrophage antigen 1 (mac-1) beta subunit); MF17; MFI7; truncated integrin beta-2
Mus musculus (house mouse) : Itgb2 (integrin beta 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgb2 (integrin subunit beta 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb2 (integrin subunit beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB2 (integrin subunit beta 2)
Canis lupus familiaris (dog) : ITGB2 (integrin subunit beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb2 (integrin subunit beta 2)
Sus scrofa (pig) : ITGB2 (integrin subunit beta 2)
Chlorocebus sabaeus (African green monkey) : ITGB2 (integrin subunit beta 2)
Heterocephalus glaber (naked mole-rat) : Itgb2 (integrin subunit beta 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2144,885,953 - 44,931,989 (-)EnsemblGRCh38hg38GRCh38
GRCh382144,885,949 - 44,928,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372146,305,864 - 46,348,753 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362145,130,296 - 45,165,303 (-)NCBINCBI36hg18NCBI36
Build 342145,130,313 - 45,165,232NCBI
Celera2131,412,498 - 31,455,256 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2131,679,225 - 31,721,357 (-)NCBIHuRef
CHM1_12145,866,651 - 45,909,384 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITGB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1313694
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.