Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:696596480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 mRNA, 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein

PMID:19632255, PMID:22262711
multiple interactionsISORGD:696596480464CTD4-((3-bromophenyl)amino)-6, 7-dimethoxyquinazoline inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3, 4-d)pyrimidine inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], acetovanillone inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], AG 1879 inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], alpha-cyano-(3, 4-dihydroxy)-N-benzylcinnamide inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], diphenyleneiodonium inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], Filipin inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], methyl-beta-cyclodextrin inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein], NSC 23766 inhibits the reaction [2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]

PMID:19632255
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.