RGD Reference Report - Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma. - Rat Genome Database

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Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma.

Authors: Shinoda, H  Huang, CC 
Citation: Shinoda H and Huang CC, Eur Arch Otorhinolaryngol. 1995;252(7):385-90.
RGD ID: 8547586
Pubmed: (View Article at PubMed) PMID:8562031

Intercellular adhesion molecule-1 (ICAM-1) may have a role in acquired cholesteatoma, which is usually associated with an inflammatory reaction occurring in the middle ear cavity. The presence of ICAM-1 in human cholesteatomas was demonstrated by an immunoblotting assay using a specific monoclonal anti-ICAM-1 antibody after protein extraction. Distribution of ICAM-1 in the cholesteatoma tissues was then studied by avidin-biotin-peroxidase complex staining. ICAM-1 appeared to be localized on keratinocytes in all layers of the epithelium and on Langerhans cells in both the epithelium and granulation tissue of cholesteatoma. ICAM-1 was not found in the epidermis of normal external ear canal skin, normal tympanic membrane or normal facial skin, but significant staining was seen on keratinocytes of hair follicles and glands in the facial skin. The present study is the first to demonstrate ICAM-1 in cholesteatoma and suggests that it may have an important role in the clinical development of cholesteatoma, including migration, adhesion and proliferation of lymphocytes, Langerhans cells and keratinocytes.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)

Additional Information