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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:15948
Term: lycopene
Definition: An acyclic carotene commonly obtained from tomatoes and other red fruits.
Chemical ID: MESH:C015329
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:696596480464CTD[Ascorbic Acid co-treated with lycopene co-treated with alpha-Tocopherol] inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA], lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 mRNA], lycopene inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein], lycopene inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]

PMID:22429818, PMID:25551565
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.