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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ICAM1 mRNA

PMID:22298810
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ICAM1 mRNA

PMID:20959002, PMID:21215274
affects expressionISORGD:107566480464CTDTetrachlorodibenzodioxin affects the expression of ICAM1 mRNA

PMID:21570461
increases expressionISORGD:107566480464CTDTetrachlorodibenzodioxin results in increased expression of ICAM1 mRNA, Tetrachlorodibenzodioxin results in increased expression of ICAM1 protein

PMID:19770486, PMID:20211938, PMID:21041162, PMID:21097750, PMID:21846477
increases expressionISORGD:696596480464CTDTetrachlorodibenzodioxin results in increased expression of ICAM1 mRNA

PMID:22262711, PMID:26238291
multiple interactionsISORGD:107566480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ICAM1 mRNA, AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ICAM1 protein], NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of ICAM1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of ICAM1 protein], Tetrachlorodibenzodioxin promotes the reaction [[Imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein], Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein]

PMID:21097750, PMID:21846477, PMID:25975270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.