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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:36560
Term: zinc oxide
Definition: A zinc molecular entity that has formula OZn.
Chemical ID: MESH:D015034
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107566480464CTDZinc Oxide analog results in increased expression of ICAM1 protein, Zinc Oxide results in increased expression of ICAM1 protein

PMID:22166487, PMID:25127755
increases expressionISORGD:696596480464CTDZinc Oxide analog results in increased expression of ICAM1 protein, Zinc Oxide results in increased expression of ICAM1 mRNA, Zinc Oxide results in increased expression of ICAM1 protein

PMID:22166487, PMID:24746987
multiple interactionsISORGD:107566480464CTDZinc Oxide analog promotes the reaction [OVAL protein results in increased expression of ICAM1 protein]

PMID:25127755
multiple interactionsISORGD:696596480464CTD[RAC1 protein binds to CDC42 protein] affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein], BAY 11-7085 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1], JUN protein affects the reaction [Zinc Oxide results in increased expression of ICAM1 protein], NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of ICAM1], pyrazolanthrone inhibits the reaction [Zinc Oxide results in increased expression of ICAM1]

PMID:22166487
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.