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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:696596480464CTDHydrogen Peroxide affects the expression of ICAM1 mRNA

PMID:20044591
increases expressionISORGD:696596480464CTDHydrogen Peroxide results in increased expression of ICAM1 mRNA, Hydrogen Peroxide results in increased expression of ICAM1 protein

PMID:11378323, PMID:25305479
multiple interactionsISORGD:696596480464CTD[Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein], Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 mRNA], Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 protein], Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 mRNA], Plant Extracts inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 protein], Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 mRNA], Polysaccharides inhibits the reaction [Hydrogen Peroxide results in increased expression of ICAM1 protein]

PMID:20351055, PMID:25305479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.