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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:696596480464CTDtert-Butylhydroperoxide results in increased expression of ICAM1 mRNA

PMID:15336504, PMID:28063877
multiple interactionsISORGD:696596480464CTD1-(3, 4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ICAM1 mRNA], LY96 protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of ICAM1 mRNA]

PMID:28063877
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.