Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of ICAM1 mRNA, Lipopolysaccharides results in increased expression of ICAM1 protein

PMID:16020654, PMID:19098112, PMID:20885979, PMID:21308383, PMID:21939782, PMID:22330755, PMID:22903158, PMID:26357463
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Carrageenan promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Cysteine analog inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Glucosamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], OGT inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], TO-901317 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:19098112, PMID:20885979, PMID:21308383, PMID:21939782, PMID:22330755
affects expressionISORGD:696596480464CTDLipopolysaccharides affects the expression of ICAM1 protein

PMID:30842373
increases expressionISORGD:107566480464CTDLipopolysaccharides results in increased expression of ICAM1 mRNA, Lipopolysaccharides results in increased expression of ICAM1 protein

PMID:10975854, PMID:17973899, PMID:19279313, PMID:21300114, PMID:21948866, PMID:22185406, PMID:23170834, PMID:25472953, PMID:25890327, PMID:27339419, PMID:30635848, PMID:8566054
increases expressionISORGD:696596480464CTDLipopolysaccharides results in increased expression of ICAM1 mRNA, Lipopolysaccharides results in increased expression of ICAM1 protein

PMID:10328874, PMID:12538815, PMID:15358673, PMID:15860229, PMID:16317058, PMID:16890772, PMID:18414230, PMID:19426978, PMID:20417223, PMID:20920494, PMID:21371465, PMID:21540303, PMID:21729627, PMID:21742781, PMID:21933601, PMID:22007554, PMID:22124178, PMID:22226621, PMID:26357463, PMID:27183587, PMID:27454768, PMID:29217270, PMID:30501627, PMID:30635848
increases secretionISORGD:107566480464CTDLipopolysaccharides results in increased secretion of ICAM1 protein

PMID:22118570
increases secretionISORGD:696596480464CTDLipopolysaccharides results in increased secretion of ICAM1 protein

PMID:21933601
multiple interactionsISORGD:107566480464CTD[CCR5 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of ICAM1 protein, [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein, [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein, [Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein, [Lipopolysaccharides co-treated with CSF2 protein] results in increased expression of ICAM1 protein, [Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of ICAM1 protein, [Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of ICAM1 protein, [Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of ICAM1 protein, chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], indole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of ICAM1 protein], sodium arsenite promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of ICAM1 protein], tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:16890772, PMID:17512567, PMID:17973899, PMID:19279313, PMID:21097750, PMID:21300114, PMID:21948866, PMID:22118570, PMID:22185406, PMID:23170834, PMID:25472953, PMID:26055553, PMID:30635848, PMID:8566054
multiple interactionsISORGD:696596480464CTD22-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], 24, 25-epoxycholesterol promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], 3, 4-dihydroxyphenylethanol inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of ICAM1 mRNA, acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], ARHGEF2 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], bicalutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]], Bucladesine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], CYBA protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], DDX58 protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Dihydrotestosterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Fluorocarbons inhibits the reaction [Lipopolysaccharides results in increased secretion of ICAM1 protein], GW 3965 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], hydroxysafflor yellow A inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], ICAM1 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein], Medroxyprogesterone Acetate inhibits the reaction [Hydrocortisone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Mifepristone inhibits the reaction [Medroxyprogesterone Acetate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Mifepristone inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], oleuropein inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Org 31710 inhibits the reaction [Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Potassium Chloride affects the reaction [Lipopolysaccharides affects the expression of ICAM1 protein], PRKCZ protein promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Progesterone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]], Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], RHOA mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], sodium arsenite promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Sodium Salicylate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], sulforafan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Tetradecanoylphorbol Acetate promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Tetradecanoylphorbol Acetate promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], TLR4 mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], TNF protein affects the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], TO-901317 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Y 27632 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein], Zinc deficiency promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA], Zinc deficiency promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:10328874, PMID:12538815, PMID:12615669, PMID:15358673, PMID:16317058, PMID:16890772, PMID:18414230, PMID:19426978, PMID:20920494, PMID:21878375, PMID:21933601, PMID:22007554, PMID:22124178, PMID:22226621, PMID:27183587, PMID:27454768, PMID:30635848, PMID:30842373, PMID:9846848
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.