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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:107566480464CTDmangiferin results in decreased expression of ICAM1 mRNA

PMID:15135318
multiple interactionsISORGD:696596480464CTDmangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]

PMID:15161907
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.