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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases acetylationEXP 6480464CTDMethylcholanthrene results in increased acetylation of ICAM1 promoter

PMID:29094188
increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of ICAM1 mRNA

PMID:29094188
multiple interactionsEXP 6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]], alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter], alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA], Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]

PMID:29094188
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.