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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:8913
Term: Ruscogenin
Definition: A triterpenoid that has formula C27H42O4.
Chemical ID: MESH:C012541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:107566480464CTDruscogenin inhibits the reaction [RELA protein affects the localization of ICAM1 protein], ruscogenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA], ruscogenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:18946195
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.