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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Icam1increases expressionISOIcam1 (Mus musculus)6480464CTDDextran Sulfate results in increased expression of ICAM1 mRNAPMID:21724996 PMID:24038091 PMID:25448682 PMID:25472953
Icam1multiple interactionsISOIcam1 (Mus musculus)6480464CTD17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ICAM1 mRNA; Dexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; fraxinellone inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]PMID:21724996 PMID:24038091 PMID:25448682 PMID:25472953 PMID:29950665
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