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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:34674
Term: dextran sulfate
Definition: A polymer composed of repeating (1->6)-alpha-linked anhydroglucose sulfate units.
Chemical ID: MESH:D016264
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:107566480464CTDDextran Sulfate results in increased expression of ICAM1 mRNA

PMID:21724996, PMID:24038091, PMID:25448682, PMID:25472953
multiple interactionsISORGD:107566480464CTD17-hydroxy-4, 7, 10, 13, 15, 19-docosahexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], 7, 14-dihydroxydocosa-4, 8, 10, 12, 16, 19-hexaenoic acid inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of ICAM1 mRNA, Dexamethasone inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], fraxinellone inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], resolvin D1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA], resolvin D2 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]

PMID:21724996, PMID:24038091, PMID:25448682, PMID:25472953, PMID:29950665
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.