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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2857
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Icam1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:696596480464CTDSodium Fluoride results in increased expression of ICAM1 mRNA, Sodium Fluoride results in increased expression of ICAM1 protein

PMID:27750169, PMID:28012895
multiple interactionsISORGD:696596480464CTDprotocatechuic acid methyl ester inhibits the reaction [Sodium Fluoride results in increased expression of ICAM1 mRNA], Sodium Fluoride inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]

PMID:10946302, PMID:28012895
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.