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Gene: ICAM3 (intercellular adhesion molecule 3) Homo sapiens
Symbol: ICAM3
Name: intercellular adhesion molecule 3
Description: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD50; CDW50; ICAM-3; ICAM-R; intercellular adhesion molecule-3
Pan paniscus (bonobo/pygmy chimpanzee) : ICAM3 (intercellular adhesion molecule 3)
Canis lupus familiaris (dog) : ICAM3 (intercellular adhesion molecule 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icam3 (intercellular adhesion molecule 3)
Sus scrofa (pig) : ICAM3 (intercellular adhesion molecule 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381910,333,776 - 10,339,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,444,452 - 10,450,345 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,305,452 - 10,311,307 (-)NCBINCBI36hg18NCBI36
Build 341910,305,453 - 10,311,300NCBI
Celera1910,339,843 - 10,345,750 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,024,713 - 10,030,606 (-)NCBIHuRef
CHM1_11910,444,986 - 10,451,054 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on ICAM3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1343048
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.