Icam1 (intercellular adhesion molecule 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Icam1 (intercellular adhesion molecule 1) Heterocephalus glaber
Analyze
Symbol: Icam1
Name: intercellular adhesion molecule 1
RGD ID: 18904916
Description: ENCODES a protein that exhibits integrin binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); cell adhesion (ortholog); cell adhesion mediated by integrin (ortholog); PARTICIPATES IN eicosanoid signaling pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,432,550 - 2,453,071 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Animal Hepatitis  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Brain Death  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiectasis  (ISO)
bronchus carcinoma  (ISO)
bullous pemphigoid  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chlamydia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic ulcer of skin  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
contact dermatitis  (ISO)
Crohn's disease  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse large B-cell lymphoma  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Enteritis  (ISO)
Eosinophilic Myocarditis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
graft-versus-host disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
Hypercholesterolemia  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
idiopathic interstitial pneumonia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
Intimal Hyperplasia  (ISO)
iridocyclitis  (ISO)
Jaundice  (ISO)
Kidney Neoplasms  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
localized scleroderma  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
Lymphocytic Myocarditis  (ISO)
malaria  (ISO)
melanoma  (ISO)
Mercury Poisoning  (ISO)
mesenteric vascular occlusion  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
paracoccidioidomycosis  (ISO)
Penetrating Wounds  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prinzmetal angina  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinopathy of prematurity  (ISO)
rheumatic fever  (ISO)
rheumatic myocarditis  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
skin melanoma  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
uveitis  (ISO)
venous insufficiency  (ISO)
Viral Myocarditis  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response to antigenic stimulus  (ISO)
cell adhesion  (IEA,ISO)
cell adhesion mediated by integrin  (ISO)
cell-cell adhesion  (IEA,ISO)
cellular response to alkaloid  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular senescence  (ISO)
establishment of endothelial barrier  (ISO)
establishment of endothelial intestinal barrier  (ISO)
establishment of Sertoli cell barrier  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukocyte migration  (ISO)
membrane to membrane docking  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
ovarian follicle development  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cellular extravasation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of activated T cell proliferation  (ISO)
regulation of cell shape  (ISO)
regulation of ruffle assembly  (ISO)
response to amino acid  (ISO)
response to amphetamine  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to gonadotropin  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
response to ionizing radiation  (ISO)
response to lipopolysaccharide  (ISO)
response to organic cyclic compound  (ISO)
response to sulfur dioxide  (ISO)
response to xenobiotic stimulus  (ISO)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
T cell antigen processing and presentation  (ISO)
T cell extravasation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Icam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,432,550 - 2,453,071 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ICAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,271,120 - 10,286,615 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,271,093 - 10,286,615 (+)EnsemblGRCh38hg38GRCh38
GRCh371910,381,796 - 10,397,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,242,779 - 10,258,291 (+)NCBINCBI36Build 36hg18NCBI36
Build 341910,242,778 - 10,258,291NCBI
Celera1910,276,917 - 10,292,687 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,965,426 - 9,977,270 (+)NCBIHuRef
CHM1_11910,381,783 - 10,397,556 (+)NCBICHM1_1
T2T-CHM13v2.01910,397,229 - 10,412,727 (+)NCBIT2T-CHM13v2.0
Icam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,927,236 - 20,940,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,927,281 - 20,940,113 (+)EnsemblGRCm39 Ensembl
GRCm38921,015,940 - 21,028,814 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,015,985 - 21,028,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,820,404 - 20,833,241 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,766,362 - 20,779,199 (+)NCBIMGSCv36mm8
Celera918,284,644 - 18,297,383 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.69NCBI
Icam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,829,688 - 27,841,618 (+)NCBIGRCr8
mRatBN7.2819,553,063 - 19,565,438 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,553,645 - 19,565,438 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,573,091 - 23,584,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,870,936 - 21,882,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,783,338 - 19,795,094 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,035,287 - 22,047,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,035,256 - 22,047,059 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,092,155 - 22,103,917 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,040,177 - 20,051,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,040,176 - 20,051,939 (+)NCBI
Celera820,948,090 - 20,959,852 (+)NCBICelera
RH 3.4 Map8206.11RGD
Cytogenetic Map8q13NCBI
Icam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,561,714 - 1,574,755 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,561,464 - 1,573,282 (+)NCBIChiLan1.0ChiLan1.0
ICAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,184,919 - 15,203,585 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,183,529 - 14,202,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,821,402 - 9,837,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,484,414 - 10,500,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,484,414 - 10,500,605 (+)Ensemblpanpan1.1panPan2
ICAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,818,715 - 50,827,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,818,715 - 50,827,914 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,688,470 - 50,697,454 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,340,345 - 51,349,327 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,340,352 - 51,349,346 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,546,484 - 50,555,463 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,975,237 - 50,984,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,216,377 - 51,225,401 (-)NCBIUU_Cfam_GSD_1.0
Icam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,727,534 - 209,738,599 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659616,752 - 627,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659616,570 - 627,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ICAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,097,122 - 69,108,205 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,097,136 - 69,107,722 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,431,462 - 69,442,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ICAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,320,991 - 9,338,125 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,322,550 - 9,338,263 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,702,922 - 10,719,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014509   ⟹   ENSHGLP00000014365
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248282,432,550 - 2,453,071 (+)Ensembl
RefSeq Acc Id: XM_004865484   ⟹   XP_004865541
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBI
RefSeq Acc Id: XM_021244993   ⟹   XP_021100652
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248282,432,584 - 2,451,997 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004865541 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100652 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014365
Reference Protein Sequences
RefSeq Acc Id: XP_004865541   ⟸   XM_004865484
- Peptide Label: isoform X1
- UniProtKB: G5B232 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100652   ⟸   XM_021244993
- Peptide Label: isoform X2
- UniProtKB: G5B232 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000014365   ⟸   ENSHGLT00000014509


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010281 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014509 ENTREZGENE
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
InterPro ICAM1_3_5_D2 UniProtKB/TrEMBL
  ICAM_N UniProtKB/TrEMBL
  ICAM_VCAM UniProtKB/TrEMBL
  ICAM_VCAM_N UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
NCBI Gene Icam1 ENTREZGENE
PANTHER INTERCELLULAR ADHESION MOLECULE UniProtKB/TrEMBL
  INTERCELLULAR ADHESION MOLECULE 1 UniProtKB/TrEMBL
Pfam ICAM1_3_5_D2 UniProtKB/TrEMBL
  ICAM_N UniProtKB/TrEMBL
PRINTS ICAMVCAM1 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
UniProt G5B232 ENTREZGENE, UniProtKB/TrEMBL