RGD Reference Report - Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats. - Rat Genome Database

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Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats.

Authors: Zhou, H  Liu, J  Pan, P  Jin, D  Ding, W  Li, W 
Citation: Zhou H, etal., Exp Biol Med (Maywood). 2010 Oct 1;235(10):1236-43. Epub 2010 Sep 1.
RGD ID: 4145365
Pubmed: PMID:20810760   (View Abstract at PubMed)
DOI: DOI:10.1258/ebm.2010.010147   (Journal Full-text)

Brain death (BD) induces acute lung injury and makes donor lungs unfit for transplantation. Carbon monoxide (CO) inhalation at 50-500 ppm exerts anti-inflammatory and anti-apoptosis effects in several lung injury models. We examined whether CO inhalation would show favorable effects on lung injury in BD rats. BD rats inhaled 250 ppm CO for two hours. Inhalation decreased the severity of lung injury, as checked by histological examination. CO treatment reversed aggravation in PaO(2)/FiO(2), base excess and pH of BD rats. CO inhalation downregulated the pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6), and inhibited activity of myeloperoxidase in lung tissue. Inhalation significantly decreased cell apoptosis of lungs, and inhibited mRNA expression of intercellular adhesion molecule-1 and caspase-3 in the lungs. Further, the inhalation activated phosphorylation of p38 expression and inhibited phosphorylation of extracellular signal-regulated kinase expression in the lungs. In conclusion, CO exerts potent protective effects on lungs from BD rats, exhibiting anti-inflammatory and anti-apoptosis functions by modulating the mitogen-activated protein kinase signal transduction.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ICAM1HumanBrain Death  ISOIcam1 (Rattus norvegicus)mRNA:increased expression:lung (rat)RGD 
Icam1RatBrain Death  IEP mRNA:increased expression:lung (rat)RGD 
Icam1MouseBrain Death  ISOIcam1 (Rattus norvegicus)mRNA:increased expression:lung (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)


Additional Information